A5052618620- Developmental Biology and Gene Regulation
- Hippo pathway signaling and YAP/TAZ
- Wnt/β-catenin signaling in development and cancer
- Quasicrystal Structures and Properties
- RNA modifications and cancer
- Cellular Mechanics and Interactions
- Aluminum Alloy Microstructure Properties
- Magnesium Alloys: Properties and Applications
- Mineralogy and Gemology Studies
- Shape Memory Alloy Transformations
- Aluminum Alloys Composites Properties
- Microstructure and Mechanical Properties of Steels
- Invertebrate Immune Response Mechanisms
- Chromosomal and Genetic Variations
- Microstructure and mechanical properties
- CRISPR and Genetic Engineering
- TGF-β signaling in diseases
- Virus-based gene therapy research
- X-ray Diffraction in Crystallography
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- Advancements in Battery Materials
- Viral gastroenteritis research and epidemiology
- Electrical and Thermal Properties of Materials
- Cell death mechanisms and regulation
University of Cambridge
2021-2024
University of Helsinki
2013-2024
Helsinki Institute of Physics
2016-2024
Harbin Medical University
2023
Second Affiliated Hospital of Harbin Medical University
2023
Czech Academy of Sciences, Institute of Biotechnology
2021
Wuhan University
1995-2018
Center for Excellence in Molecular Cell Science
2011-2015
Chinese Academy of Sciences
1995-2015
Shanghai Institutes for Biological Sciences
2011-2015
PIWI proteins and their guiding Piwi-interacting small RNAs (piRNAs) are crucial for fertility transposon defense in the animal germline. In most species, majority of piRNAs produced from distinct large genomic loci, called piRNA clusters. It is assumed that germline-expressed clusters, particularly Drosophila, act as principal regulators to control transposons dispersed across genome. Here, using synteny analysis, we show clusters evolutionarily labile, arise at loci characterized by...
Abstract The tight control of fate transitions during stem cell differentiation is essential for proper tissue development and maintenance. However, the challenges in studying sparsely distributed adult cells a systematic manner have hindered efforts to identify how multilayered regulation gene expression programs orchestrates vivo. Here, we synchronised Drosophila female germline (GSC) vivo perform in-depth transcriptome translatome analyses at high temporal resolution. This...
Abstract Comprehensive analysis of cellular dynamics during the process morphogenesis is fundamental to understanding principles animal development. Despite recent advancements in light microscopy, how successive cell shape changes lead complex three-dimensional tissue still largely unresolved. Using vivo live imaging Drosophila wing development, we have studied unique structures comprising a microtubule-based membrane protrusion network. This network, which name here Interplanar Amida...
Piwi controls the number of primordial germ cells (PGCs) via protecting maternal mRNA from decay and adult stem cell division in Drosophila. In mouse zebrafish, piwi maintenance differentiation during gametogenesis. Whether plays a role PGC development vertebrates remains unsolved. We addressed this issue by using medaka (Oryzias latipes) as vertebrate model. Molecular cloning, sequence comparison analyses genomic organization chromosome synteny led to identification fish single gene, called...
Lithium is an effective mood stabilizer that has been clinically used to treat bipolar disorder for several decades. Recent studies have suggested lithium possesses robust neuroprotective and anti-tumor properties. Thus far, a large number of targets discovered. Here, we report the first time HDAC1 target lithium. significantly down-regulated at translational level by targeting mRNA. We also showed depletion essential effects lithium-mediated degradation mutant huntingtin through autophagic...
Epithelial cells are characterized by apical-basal polarity. Intrinsic factors underlying polarity crucial for tissue homeostasis and have often been identified to be tumor suppressors. Patterning differentiation of epithelia key processes epithelial morphogenesis frequently regulated highly conserved extrinsic factors. However, due the complexity morphogenesis, mechanisms precise interpretation signal transduction as well spatiotemporal control cues during dynamic remain poorly understood....
Tissue development and homeostasis depend on the balance between growth terminal differentiation, but mechanisms coordinating these processes remain elusive. Accumulating evidence indicates that ribosome biogenesis (RiBi) protein synthesis, two cellular sustaining growth, are tightly regulated yet can be uncoupled during stem cell differentiation. Using Drosophila adult female germline larval neuroblast systems, we show Mei-P26 Brat, TRIM-NHL paralogs, responsible for uncoupling RiBi...
Aberrant JAK/STAT3 pathway has been reported to be related hepatocellular carcinoma (HCC) in many cell lines. In this study, a double-regulated oncolytic adenovirus vector that can replicate and induce cytopathic effect alpha-fetoprotein (AFP)-positive HCC lines with p53 dysfunction was successfully constructed. Two therapeutic genes, suppressor of cytokine signaling 3 (SOCS3) tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), were chosen incorporated into system, respectively....
Significance Tissue morphogenesis is a dynamic process often accompanied by cell patterning and differentiation. Although how conserved growth factor signaling affects tissue shapes has been actively studied, much less known about are mutually coordinated. Our study shows that BMP 3D of the Drosophila pupal wing tightly coupled. These findings highlighted fact directionality signal changed from lateral planar during inflation stage to interplanar after re-apposition dorsal ventral epithelia....
Abstract Deregulation of c‐ MYC occurs in a variety human cancers. Overexpression promotes cell growth, proliferation, apoptosis, transformation and genomic instability. target 1 ( MYCT 1) is direct gene , its murine homologue MT ‐ MC recapitulated multiple c‐Myc‐related phenotypes. However, the molecular mechanism remains unclear. Here, we identified transmembrane TM ) domain 1, not nuclear localization sequence, indispensable to vesicle‐associated protein cytoplasmic membrane vesicle. (Δ...
The bone morphogenetic protein (BMP) signaling network, comprising evolutionary conserved BMP2/4/Decapentaplegic (Dpp) and Chordin/Short gastrulation (Sog), is widely utilized for dorsal-ventral (DV) patterning during animal development. A similar network required posterior crossvein (PCV) formation in the Drosophila pupal wing. Although both transcriptional post-transcriptional regulation of co-factors gives rise to tissue-specific species-specific properties, their mechanisms are...
The general principle of the projection method and an index scheme for decagonal phases are described systematically. Kikuchi-line patterns over a large angular range from Al 70 Co 15 Ni quasicrystal with periodicity 4 A along tenfold axis were obtained by connecting series large-angle convergent-beam electron diffraction patterns. Computer-simulated major zone axes covering whole orientation triangle show good agreement recorded experimentally. After discussion inflation deflation...
Abstract Development and tissue maintenance require a supply of new cells, which are generated by division stem cells then specialised to perform their function. The differentiation process requires the tight control gene expression, but this has been challenging study in systematic manner adult sparsely distributed tissues. We have overcome these limitations establishing robust protocol synchronise Drosophila female germline cell (GSC) vivo , allowing us transcriptome translatome analyses...