A5101918816- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Cancer-related gene regulation
- Advanced Software Engineering Methodologies
- Cloud Computing and Resource Management
- Protein Degradation and Inhibitors
- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Polyamine Metabolism and Applications
- Magnesium Alloys: Properties and Applications
- Model-Driven Software Engineering Techniques
- Scheduling and Optimization Algorithms
- Service-Oriented Architecture and Web Services
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Lung Cancer Research Studies
- Clusterin in disease pathology
- Distributed and Parallel Computing Systems
- RNA Interference and Gene Delivery
Tongde Hospital of Zhejiang Province
2019-2023
Fourth Affiliated Hospital of China Medical University
2019-2022
China Medical University
2019-2022
Xi'an Chest Hospital
2021
China Academy of Railway Sciences
2018
Naval Aeronautical and Astronautical University
2015
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with poor prognosis. Insights into the roles of MicroRNAs (miRNAs) in diseases, particularly cancer, have made miRNAs attractive tools and targets for novel therapeutic approaches. Methods: Here, we employed chimeric peptide supramolecular nanoparticle delivery system plectin-1 (PL-1)-targeted PDAC-specific miR-9 vitro pancreatic cancer patient-derived xenograft (PDX) model. RT-PCR immunohistochemistry (IHC) were conducted to...
Sini decoction (SND) is a widely used Traditional Chinese Medicine (TCM). The reports of SND application in colorectal cancer (CRC) limited.The objective this study to investigate the anti-tumor activity treatmeant CRC.SND was analyzed using high-performance liquid chromatography. A CRC metastasis model established murine CT-26 cells. Whole-body fluorescence imaging observe liver metastasis. Liver morphology determined hematoxylin-eosin staining. Cytokine mRNA expression (interleukin-2...
Abstract Background Cholangiocarcinoma (CCA) is the second most common primary liver malignancy worldwide. Several microRNAs (miRNAs) have been implicated as potential tumor suppressors in CCA. This study aims to explore effects of miR-1182 and let-7a on CCA development. Methods Bioinformatics analysis was conducted screen differentially expressed genes CCA, Western blot detected NUAK1 protein expression RT-qPCR miR-1182, tissues cell lines. Dual luciferase reporter gene assay RIP were...
Hepatocellular carcinoma (HCC) is one of the most malignant tumors worldwide and HCC patients often develop drug resisitene. Long non-coding RNAs (LncRNAs) are closely related to cell cycle, growth, development, differentiation, apoptosis. Abnormally expressed lncRNAs have been proved mediate resistance in tumor cells. However, effect LIMT on has not explored HCC. In this study, we long RNA its underlying mechanism hepatocellular (HCC). Our results showed that LncRNA LINC01089 (LIMT)...
Esophageal carcinoma (EC) is recognized as one of the most frequently occurring malignancies worldwide, and its high morbidity rate motivates efforts to identify potential therapeutic targets. Notably, forkhead box (FOX) family genes are highlighted possible biomarkers for diagnostics, prognostics, therapeutics various malignancies, including EC. Our present study was performed investigate underlying mechanism FOXO6 on development We observed a significant upregulation in EC tissues,...
Esophageal squamous cell carcinoma (ESCC) ranks among the five most common cancers in China and has a five-year survival rate of less than 15%. The transcription factor ATPase-family AAA-domain-containing protein 2 (ATAD2) potential as therapeutic target various tumors, microarray-based gene expression profiling reveals dysregulation ATAD2 specifically ESCC. Here we investigated whether could mediate regulation cancer stem (CSC) biological functions Immunohistochemical staining, reverse...
The traditional document-based system engineering method used in EMU design progress has the disadvantage of inconsistent information, incorrect version and poor readability. In some industrial fields, model-based systems (MBSE) methods have been widely developed applied recent years. Alstom Bombardier also attempted to adopt MBSE their rolling stock product improve quality, efficiency reduce development risk. An attempt based on approach China was introduced, taking door control as an...