A5102976365- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Growth Hormone and Insulin-like Growth Factors
- RNA modifications and cancer
- DNA Repair Mechanisms
- Cancer, Lipids, and Metabolism
- Facial Trauma and Fracture Management
- Metastasis and carcinoma case studies
- Cell death mechanisms and regulation
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Genomics, phytochemicals, and oxidative stress
- Glycosylation and Glycoproteins Research
- Gastric Cancer Management and Outcomes
- Urologic and reproductive health conditions
- Lung Cancer Research Studies
- Ophthalmology and Visual Impairment Studies
- Sarcoma Diagnosis and Treatment
- Immune cells in cancer
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects of Natural Compounds
Shanghai Jiao Tong University
2025
China Medical University
2012-2024
First Hospital of China Medical University
2012-2024
Affiliated Zhongshan Hospital of Dalian University
2016-2024
Fuzhou University
2022-2024
Zhejiang Chinese Medical University
2024
Hebei Medical University
2021-2023
Second Hospital of Hebei Medical University
2021-2023
Harbin Medical University
2023
Shunyi Hospital of Beijing Traditional Chinese Medicine Hospital
2023
Recent advances in the field of circulating tumor cells (CTC) have shown promise this liquid biopsy-based prognosis patient outcome. However, not all are cells, as evidenced by a lack tumor-specific markers. The current FDA standard for capturing CTCs (CellSearch) relies on an epithelial marker and captured via CellSearch cannot be considered to undergone EMT. Therefore, it is difficult ascertain presence relevance any mesenchymal or EMT-like CTCs. To address gap technology, we recently...
Abstract Metastasis is the most important reason for poor prognosis of gastric cancer (GC) patients, and mechanism urgently needs to be clarified. Here, we explored a prognostic model estimation tumor-associated mortality in GC patients revealed RNA-binding protein RBMS1 as candidate promoter gene metastasis by analyzing GOBO Oncomine high-throughput sequencing datasets 408 patients. Additionally, was observed with overexpression 85 patient clinical specimens IHC staining further verified...
Abstract Background Circulating tumor cells (CTCs) hold immense promise in guiding treatment strategies for advanced gastric cancer (GC). However, their clinical impact has been limited due to challenges identifying epithelial-mesenchymal transition (EMT)-CTCs using conventional methods. Methods To bridge this knowledge gap, we established a detection platform CTCs based on the distinctive biomarker cell surface vimentin (CSV). A prospective study involving 127 GC patients was conducted,...
Insulin-like growth factor I (IGF-I) can induce epithelial mesenchymal transition (EMT) in many tumors; however, the molecular mechanism by which this occurs is not clearly understood. Additionally, little known about involvement of IGF-I gastric cancer. Two cancer cell lines were treated with to EMT and levels transcription ZEB2 microRNA-200c (miR-200c) measured. Cells Akt/ERK inhibitors investigate role these pathways IGF-I-mediated EMT. Transfection shRNA plasmids was used silence...
Although circulating tumor cells (CTCs) have shown promise as potential biomarkers for diagnostic and prognostic assessment in gastric cancer (GC), determining the predictive value of programmed death-ligand 1 (PD-L1)-positive CTCs patients with GC is a challenge. Here, we identified that expression total vimentin (VIM) protein was positively correlated PD-L1 inhibited CD8+ T-cell activation according to bioinformatics analysis. Notably, coexpression cell-surface VIM (CSV) detected by...
Abstract Background Hyperfibrinogenemia is a common problem associated with various carcinomas, and accompanied by hypercoagulablity. In advanced non-small-cell lung cancer (NSCLC) it remains unclear whether or not chemotherapy-induced changes in fibrinogen level relate to chemotherapeutic response prognosis. The purposes of this study were to: 1) analyze the association between plasma after first two courses standard first-line platinum-based chemotherapy; 2) evaluate prognostic...
Metastasis is the most common cause of mortality in patients with gastric cancer. Epithelial-to-mesenchymal transition (EMT), which may be stimulated by insulin-like growth factor-I (IGF-I) involved metastasis numerous tumors; however, molecular mechanism IGF-I induce tumor cell EMT remains to elucidated The present study aimed investigate induction BGC-823 cancer cells. It was identified that induced upregulating levels ZEB2 transcription factor, and this dependent on phosphoinositide...
The clinical utility of circulating tumor cells (CTCs) has been investigated in numerous publications, but CTCs that express very typical immune cell markers have not reported. Here we report a novel class CTCs—CSV-positive macrophage-like (ML-CTCs). This nomenclature was based on the fact this can be captured from blood samples gastrointestinal stromal tumors (GISTs) patients using either macrophage marker CD68 or our proprietary tumor-specific cell-surface vimentin (CSV) antibody 84–1;...
Neuroblastoma (NB) is a deadly childhood disease that carries 50% chance of relapse for anyone in remission and similar level 5-year survival. We investigated the value our proprietary approach—cell surface vimentin (CSV) positive circulating tumor cells (CTC) to monitor treatment response predict NB patients under Phase II long-term preventative clinical trial. longitudinally analyzed peripheral blood samples from 93 27 cycles (~25 months) discovered presence CSV+ CTCs first two sequential...
Purpose To evaluate the long-term outcomes of ciliary sulcus versus capsular bag fixation intraocular lenses (IOLs) in children after pediatric cataract surgery. Methods IOL was implanted 21 eyes 14 children, and 19 12 for treatment an institutional setting. Ultrasound biomicroscopy (UBM) performed. Main outcome measures included decentration, tilt, anterior chamber depth (ACD), angle-opening distance at 500 μm (AOD500), trabecular-iris angle (TIA), best-corrected visual acuity (BCVA),...
Background The relationship between passive smoking exposure (PSE) and breast cancer risk is of major interest. Objective To evaluate the PSE from partners stratified by hormone-receptor (HR) status in Chinese urban women population. Design Hospital-based matched case control study. Setting patients without current or previous active history China Medical University 1st Hospital, Liaoning Province, Jan 2009 Nov 2009. Patients Each patient was 1∶1 with healthy controls gender age (±2 years)...
Recurrence and distant metastasis are the most common cause of therapeutic failure in nasopharyngeal carcinoma (NPC) patients. Insulin-like growth factor I (IGF-I) can induce epithelial-to-mesenchymal transition (EMT) many epithelial tumors; however, whether IGF-I enhance NPC by EMT mechanisms remain unclear. Herein, we have identified that could migration ability cell lines. Furthermore, both Src inhibitor microRNA-30a (miR-30a) reversed IGF-I-induced EMT, suggesting involvement an...
Although ionizing radiation (IR) has provided considerable improvements in nasopharyngeal carcinoma (NPC) treatment, radioresistance is still a major threat for some subsets of patients. The insulin-like growth factor-1 receptor (IGF-1R) signaling pathway tightly regulated and plays critical roles mediating cell proliferation, growth, survival. Thus, IGF-1R may be potential therapeutic target patients with different malignancies. However, its mechanism NPC not fully investigated. Linsitinib...