A5088066238- Inflammatory Bowel Disease
- Microscopic Colitis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- Cancer Research and Treatments
- Autoimmune and Inflammatory Disorders
- Mycobacterium research and diagnosis
- Immunodeficiency and Autoimmune Disorders
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Genomics, phytochemicals, and oxidative stress
- Peptidase Inhibition and Analysis
- Medical Research and Treatments
- Diverticular Disease and Complications
- Cancer Genomics and Diagnostics
Southeast University
2022-2024
China Animal Health and Epidemiology Center
2022-2024
Fudan University
2022-2024
China Medical University
2014-2023
First Hospital of China Medical University
2012-2023
Yunnan Center for Disease Control And Prevention
2023
Zhongshan Hospital
2022
General Hospital of Shenyang Military Region
2014
Nanjing Medical University
2014
Abstract Recently, a novel class of transcripts, long non-coding RNAs (lncRNAs), is being identified at rapid pace. These have critical roles in diverse biological processes, including tumorigenesis. Here we report that taurine-upregulated gene 1 ( TUG1 ), 7.1-kb lncRNA, recruiting and binding to polycomb repressive complex 2 (PRC2), generally downregulated non-small cell lung carcinoma (NSCLC) tissues. In cohort 192 NSCLC patients, the lower expression was associated with higher TNM stage...
Abstract Metastasis is the most important reason for poor prognosis of gastric cancer (GC) patients, and mechanism urgently needs to be clarified. Here, we explored a prognostic model estimation tumor-associated mortality in GC patients revealed RNA-binding protein RBMS1 as candidate promoter gene metastasis by analyzing GOBO Oncomine high-throughput sequencing datasets 408 patients. Additionally, was observed with overexpression 85 patient clinical specimens IHC staining further verified...
Abstract Macrophages are involved in tissue homeostasis and critical for innate immune responses, yet distinct macrophage populations different tissues exhibit diverse gene expression patterns biological processes. While tissue-specific epigenomic transcriptomic profiles have been reported, proteomes of remain poorly characterized. Here we use mass spectrometry bulk RNA sequencing to assess the proteomic patterns, respectively, 10 primary from seven mouse tissues, bone marrow-derived...
Aim To assess the endoscopic activity and Clinical after a one-year period of infliximab therapy to evaluate association between mucosal healing need for retreatment stopping in patients with Inflammatory bowel disease (IBD). Methods The data from 109 Crohn's (CD) 107 Ulcerative colitis (UC) received were assessed. primary endpoint study was proportion clinical remission, full remission IBD maintenance therapy. secondary frequency relapses next year. Results A total 84.4% (92/109) CD 81.3%...
ALKBH5 and YTHDF1 are regarded as the eraser reader, respectively, in N6-methyladenosine (m6A) modification. Recently, immune contexture has been drawing increasing attention terms of progression treatment cancers. This study aimed to determine relationship between ALKBH5/YTHDF1 immunological characteristics colon adenocarcinoma (COAD).Expression was investigated across TCGA GEO validated our study. Patients with COAD were divided into two clusters using consensus clustering based on...
Introduction LDH-A, the enzyme responsible for transforming pyruvate into lactate, has been demonstrated to be up-regulated in many types of cancer and give rise more aggressive behavior by regulating proliferation anti-apoptosis. However, its expression gastric (GC) not characterized thoroughly. The purpose this study was clarify potential impact LDH-A GC. Methods We examined immunohistochemistry on GC tissue microarray (TMA) using Western blot fresh tissues cell lines. Prognostic value...
The gut microbiota, which may affect normal physiological and biochemical functions, has an important role in the development of human liver diseases. aim present study was to investigate differences microbiota between chronic alcoholic fatty disease (AFLD) metabolic‑associated (MAFLD). AFLD induced by alcohol administration MAFLD a Western‑style diet C57BL/6 mice. After 8 weeks, levels plasma alanine aminotransferase (ALT), aspartate (AST), triglyceride (TG), total cholesterol (TC),...
Sine oculis homeobox homologue 1 (SIX1) is a Six class gene conserved throughout many species. It has been reported to act as an oncogene and overexpressed in cancers. However, the function regulatory mechanism of SIX1 gastric cancer (GC) remains unclear. In our study, we detected protein levels via immunohistochemistry (IHC) its proliferation invasion effects CCK8 transwell assays. Additionally, expression cyclin D1, MMP2, p‐ERK, EMT‐related proteins was measured by western blotting. We...
Bone morphogenetic proteins and activin membrane-bound inhibitor (BAMBI) drosophila mothers against decapentaplegic protein 7 (Smad7) are known to negatively regulate the transforming growth factor-β (TGF-β) signaling play an important role in progression of many malignant tumors. However, it remains unclear whether expression BAMBI alone or combination with Smad7 is associated gastric cancer. In present study, we investigated 276 cancer tissues 263 tumor-adjacent from patients, using...
The antimicrobial peptide cathelicidin inhibits development of colitis-associated colon cancer. However, the role in cancer metastasis remains unknown. We hypothesized that is effective inhibiting metastasis. Human HT-29 cells were injected intravenously into nude mice. Control HA-tagged adeno-associated virus (HA-AAV) or cathelicidin-overexpressing AAV (CAMP-HA-AAV) mice on same day. Four weeks later, assessed for lung and liver metastases. SW620 used to study effect cell migration...
Smad interacting protein 1 (SIP1) plays an important role in the epithelial-mesenchymal transition (EMT) process by downregulating E-cadherin. Lactate dehydrogenase A (LDHA) is a crucial enzyme that final step of Warburg effect converting pyruvate to lactate irreversibly. EMT and are hallmarks advanced gastric cancer progression. Recently, has been thought be implicated metabolism. In this study, we want find whether there was correlation between expressions SIP1 LDHA expression alone or...
// Tianmiao Ma 1, 2 , Hao Li 1 Mingjun Sun Yuan and Li-Ping Tumor Etiology Screening Department of Cancer Institute General Surgery, The First Affiliated Hospital China Medical University, Liaoning Provincial Education Department, Key Laboratory Prevention, Shenyang, Liaoning, Digestive Correspondence to: Sun, email: lpsun@cmu.edu.cn Yuan, yuanyuan@cmu.edu.cn Keywords: DNMT1, gastric cancer, meta-analysis, bioinformatic analysis Received: August 02, 2017 Accepted: September 20, Published:...
MTA3 overexpression has been implicated in carcinogenesis. The aim of the present study was to explore clinical significance and biological roles human colorectal cancer cells. A total 80 cases tissues were examined by immunohistochemistry for protein expression. We analyzed relationship between factors results showed that overexpressed 51.25% (41/80) cases. There significant associations advanced TNM stage (p = 0.0086) Ki67 index 0.001). LoVo cells depleted its expression HCT15 promoted...
The cancer microbiota was considered the main risk factor for progression. We had proved that Fusobacterium periodonticum (F.p) higher abundance in Esophageal cancer(EC)tissues. Bioinformation analysis found BCT a key virulence protein of F.p. However, little is known about role and mechanism EC. This study aimed to recognize F.p explore promoting
Abstract Background Gastric cancer (GC) represents a major malignancy and is the third deathliest globally. Several lines of evidence indicate that epithelial-mesenchymal transition (EMT) has critical function in development gastric cancer. Although plentiful molecular biomarkers have been identified, precise risk model still necessary to help doctors determine patient prognosis GC. Methods Gene expression data clinical information for GC were acquired from The Cancer Genome Atlas (TCGA)...
Long non-coding RNAs (lncRNAs) have emerged as major players in many biological and pathological processes; however, investigation into the function of lncRNAs development progression cancer is its infancy. Therefore, clarification mechanism by which cancer‑related critical importance research on tumorigenesis. It has been demonstrated that lncRNA XLOC_010588 expressed at a low level cervical cancer, this significant impact proliferation cells. However, expression pattern functional roles...