The prognostic significance of tumor burden score (TBS) on patients who underwent curative-intent resection intrahepatic cholangiocarcinoma (ICC) has not been evaluated. present study aimed to investigate the impact TBS and its synergistic effect with CA19-9 (combination CA19-9, CTC grade) long-term outcomes. Patients radical ICC between 2009 2017 were retrospectively identified from a multi-center database. overall survival (OS) recurrence-free (RFS) examined in relation TBS, serum...

The purpose of this study was to report on a series 162 patients presenting with juvenile nasopharyngeal angiofibroma in single academic hospital during the past 17 years, an effort compare outcomes between open and transnasal endoscopic approach, define ideal treatment strategy.Patients who received either or surgery minimum follow-up 6 months were selected. Local control complications compared groups.Retrospectively, clinical data, surgical reports, pre- postoperative images, information...

Treatment with immune checkpoint inhibitors, widely known as blockade therapy (ICBT), is now the fourth pillar in cancer treatment, offering chance of durable remission for patients advanced disease. However, ICBT fails to induce objective responses most still others progressing after an initial response. It necessary, therefore, elucidate primary and acquired resistance mechanisms improve its efficacy. Here, we highlight paradoxical role cytokine interferon-γ (IFN-γ) response: on one hand...

Colorectal cancer is a major public health problem and fourth guiding cause of cancer-induced mortality worldwide. The five-year survival rate for patients with colorectal remains poor, almost half present recurrence die within five years. increasing studies showed that long non-coding RNA (lncRNA) was involved in cancer. Therefore, this study used to explore molecular mechanisms nuclear paraspeckle assembly transcript 1 (NEAT1) real-time quantitative polymerase chain reaction (RT-qPCR)...

To investigate the relationship between lysosome-associated protein transmembrane-4β-35 (LAPTM4B-35) and clinicopathological features prognosis of pancreatic carcinoma.The level LAPTM4B-35 was determined by semi quantitative immunohistochemistry in carcinoma specimens. The using univariate multivariate analyses.A total 98 patient samples were included. presence confirmed 77/98 (78.6%) patients significantly associated with tumour stage, degree differentiation pathological staging after...

The present study investigated the role of microRNA (miR)‑138‑5p in regulating carcinoma migration and sensitivity to chemotherapy pancreatic cancer. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used assess expression levels miR‑138‑5p cancer cell lines primary tissues from human patients. A lentiviral vector, containing mimics (lv‑miR‑138‑m) or inhibitor (lv‑miR‑138‑i), either upregulate downregulate PANC‑1 cells, respectively. effects miR‑138‑3p regulation on...

Dysregulation of circular RNAs (circRNAs) has been reported to be functionally associated with chronic pain, but it is unknown whether and how circRNAs participate in visceral hypersensitivity. The expression circKcnk9 was increased spinal neurons irritable bowel syndrome (IBS)-like rats. ShcircKcnk9 attenuated hypersensitivity inhibited c-Fos IBS-like rats, whereas overexpression induced control Furthermore, found act as a miR-124-3p sponge. MiR-124-3p antagomir restored pain responses...

Background The pathogenesis of multiple chronic visceral pain syndromes, such as irritable bowel syndrome (IBS), is not well known, and a result current therapies are ineffective. objective this study was to investigate the effect spinal protein kinase M zeta (PKMζ) on sensitivity in rats with IBS better understand inhibitory peptide (ZIP) therapy for pain. Methods Visceral hypersensitivity were produced by neonatal maternal separation (NMS). assessed electromyographic (EMG) responses...

Abstract Background The indocyanine green (ICG) clearance test is the main method of evaluating liver reserve function before hepatectomy. However, some patients may be allergic to ICG or equipment was lack, leading difficult evaluate function. We aim find an alternative tool assist clinicians for those who were lack Methods retrospected 300 investigate risk factors affecting and build equivalent formula predict 15 min retention rate (ICG-R15) value. Results found that independent total...

The cancer microbiota was considered the main risk factor for progression. We had proved that Fusobacterium periodonticum (F.p) higher abundance in Esophageal cancer(EC)tissues. Bioinformation analysis found BCT a key virulence protein of F.p. However, little is known about role and mechanism EC. This study aimed to recognize F.p explore promoting

Abstract Background The surgical indications and therapeutic strategies for early‐stage multifocal recurrent hepatocellular carcinoma (rHCC) remain controversial. This study compared the long‐term outcome of patients with HCC meeting Barcelona Clinic Liver Cancer (BCLC) stage A repeat hepatectomy (RH) RH combined intraoperative radiofrequency ablation (RFA). Methods total 109 consecutive intrahepatic rHCC within BCLC following or + RFA were retrospectively collected from April 2010 to May...

Sarcopenia was recently identified as a poor prognostic factor in patients with malignant tumors. The present study investigated the effect of preoperative albumin-globulin score (AGS), skeletal muscle index (SMI), and combination AGS SMI (CAS) on short- long-term survival outcomes following deceased donor liver transplantation (DDLT) for hepatocellular carcinoma (HCC) aimed to identify factors.A total 221 consecutive who underwent DDLT HCC were enrolled this retrospective between January...

A previous randomized controlled trial demonstrated that intermittent Pringle's maneuver (IPM) with a 25-min ischemic interval could be applied safely and efficiently in hepatectomy for patients hepatocellular carcinoma (HCC). But prolonging the hepatic inflow clamping time will inevitably aggravate ischemia-reperfusion injury. Therefore, we aimed to evaluate effect of prophylactic dexamethasone on alleviating surgical stress HCC interval.From December 2022 April 2023, who met inclusion...

<title>Abstract</title> <bold>Background</bold>: Among various blood flow control techniques, the intermittent Pringle’s maneuver (IPM) remains most convenient and widely used method to reduce bleeding during hepatic resection (HR). Now, impact of IPM on human hepatocellular carcinoma (HCC) recurrence is still unclear. Currently, there has no randomized controlled trial (RCT) directly confirm tumor for HCC patients undergoing HR. Since 2019, our team been investigating effect 25-min liver...

<title>Abstract</title> Background Previous observational studies have suggested a potential link between immune cell and blood metabolite levels lung cancer risk, but the causality remains unclear. We aimed to investigate this relationship using two-sample Mendelian randomization (MR) study explore mediation by metabolites. Methods Genome-wide association (GWAS) exposure data were extracted from in 3757 Europeans 8192 ultimately analyzed integration with GWAS dataset of European cases...

The value of liver enzymes, such as alanine aminotransferase (ALT), aspartate (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT), in predicting the prognosis intrahepatic cholangiocarcinoma (ICC) patients who underwent curative resection has not been elucidated. Therefore, we aimed to construct prognostic nomograms for surgically treated ICC patients.

BackgroundThis study aimed to find effective treatments for the patient within UCSF criteria.MethodsThis enrolled 1006 patients meeting criteria, undergoing hepatic resection (HR), divided into two groups: single tumor group and multiple tumors group. We compared analyzed risk factors between these groups' long-term outcomes, through log-rank test, cox proportional hazards model using neural network analysis identify independent factors.ResultsThe 1-, 3-, 5-year OS rates in were...

Abstract Background Our previous randomized controlled trial (RCT) have demonstrated that intermittent Pringle’s maneuver (IPM) with a 25-min ischemic interval can be applied safely and efficiently in open or laparoscopic hepatectomy patients hepatocellular carcinoma (HCC) patients. But prolonging the hepatic inflow blocking time will inevitably aggravate ischemia-reperfusion injury (IRI) caused by systemic response. This RCT aims to evaluate effect of administration dexamethasone versus...