A5085608541- Liver physiology and pathology
- Ferroptosis and cancer prognosis
- Pluripotent Stem Cells Research
- Pancreatic function and diabetes
- Genetic Mapping and Diversity in Plants and Animals
- Genetic diversity and population structure
- IL-33, ST2, and ILC Pathways
- Circadian rhythm and melatonin
- Spinal Cord Injury Research
- Organ Transplantation Techniques and Outcomes
- Immune cells in cancer
- Pharmacogenetics and Drug Metabolism
- Inflammasome and immune disorders
- 3D Printing in Biomedical Research
- Inflammatory mediators and NSAID effects
- Drug Transport and Resistance Mechanisms
- Proteins in Food Systems
- Extracellular vesicles in disease
- interferon and immune responses
- Gastrointestinal motility and disorders
- Immune responses and vaccinations
- Microbial Metabolism and Applications
- Pickering emulsions and particle stabilization
- Dengue and Mosquito Control Research
- Polyamine Metabolism and Applications
Xiangya Hospital Central South University
2016-2025
Central South University
2016-2025
Jilin Medical University
2025
Fujian Medical University
2018-2024
First Affiliated Hospital of Fujian Medical University
2024
Guangxi Medical University
2024
First Affiliated Hospital of GuangXi Medical University
2024
Xihua University
2024
Center for Excellence in Molecular Cell Science
2018-2023
University of Chinese Academy of Sciences
2018-2023
Acute liver failure (ALF) is a life-threatening disease that occurs secondary to drug toxicity, infection or devastating immune response. Orthotopic transplantation an effective treatment but limited by the shortage of donor organs, requirement for life-long suppression and surgical challenges. Stem cell promising alternative therapy fulminant owing immunomodulatory abilities stem cells. Here, we report when transplanted into liver, human endoderm cells (hEnSCs) are germ layer-specific...
Abstract Background The fungus Marssonina brunnea is a causal pathogen of leaf spot that devastates poplar plantations by defoliating susceptible trees before normal fall drop. Results We sequence the genome M. with size 52 Mb assembled into 89 scaffolds, representing first sequenced Dermateaceae genome. By inoculating this onto hybrid clone, we investigate how interacts and co-evolves its host to colonize leaves. While handful virulence genes in , mostly from LysM family, are detected...
Microsatellite markers or Simple Sequence Repeats (SSRs) are the most popular in population/conservation genetics. However, development of novel microsatellite has been impeded by high costs, a lack available sequence data and technical difficulties. New species-specific were required to investigate evolutionary history Euphratica tree, Populus euphratica, only tree species found desert regions Western China adjacent Central Asian countries.A total 94,090 non-redundant Expressed Tags (ESTs)...
The ever-increasing therapeutic and pharmaceutical demand for liver cells calls systems that enable mass production of hepatic cells. Here we describe a large-scale suspension system uses human endoderm stem (hEnSCs) as precursors to generate functional transplantable hepatocytes (E-heps) or cholangiocytes (E-chos). hEnSC-derived populations are characterized by single-cell transcriptomic analyses compared with hESC-derived counterparts, in-vitro-maintained -expanded primary adult cells,...
Sub-health is a state featuring deterioration in physiological function between health and illness, the sub-health condition has surfaced as life-threatening humans. The aim of present study was to establish model rats, investigate intestinal barrier rats following intervention. To sub‑health model, were subjected high‑fat sugar diet, motion restriction chronic stress. Their serum glucose triglyceride levels, immune adaptability then measured. levels diamine oxidase D‑lactic acid plasma...
Although more pathologic stage-I lung adenocarcinoma (LUAD) was diagnosed recently, some relapsed or distantly metastasized shortly after radical resection. The study aimed to identify biomarkers predicting prognosis in the LUAD and improve understanding of mechanisms involved tumorigenesis. We obtained expression profiling data for non-small cell cancer (NSCLC) patients from NCBI-GEO database. Differentially expressed genes (DEGs) between early-stage NSCLC normal tissue were determined....
Abstract Multiplex PCR amplification of microsatellites has significantly increased the throughput and decreased costs genotyping. We have developed two highly polymorphic microsatellite multiplexes for Populus euphratica , only tree species found in desert regions Western China adjacent Central Asian countries. The first these multiplex kits comprises an eight‐Plex genomic SSRs ( gSSR s) obtained from published databases. second eight‐plex newly designed EST‐SSRs eSSR based on expressed...
Mitogen- and stress-activated kinase (MSK) 1 is a nuclear serine/threonine kinase. In the central nervous system, it plays an important role in regulating cell proliferation neuronal survival; also involved astrocyte inflammation inhibition of inflammatory cytokine production. However, its specific spinal cord injury not clear. Here, we aimed to elucidate this using vivo animal model. study, found that MSK1 gradually decreased, starting day after lowest level 3 days post-injury, which...
To develop a functional alternative hepatocyte model for primary human hepatocytes (PHHs) with proliferative property, essential drug metabolic, and transporter functions, proliferating (ProliHHs) expanded from PHHs were fully characterized in vitro. Herein, ProliHHs generated multiple donors could be more than 200-fold within four passages maintained their metabolic or capacities partially. Furthermore, able to regain the mature hepatic property after three-dimensional (3D) culture....
This study firstly developed a hiPSC-derived lineage-specific SMC-on-a-chip model and identified the segmental aortic heterogeneity. The can be used for disease modelling, drug testing personalised treatment.
To investigate the effect of keratin 23 (KRT23) on anticancer activity melatonin (MLT) against gastric cancer (GC) cells, microarray analysis was applied to screen differentially expressed genes in AGS GC cells following MLT treatment. Western blotting used detect expression KRT23 and normal epithelial cell line GES‑1. knockout achieved by CRISPR/Cas9. Assays viability, colony formation, cycle, electric cell‑substrate impedance sensing western were conducted reveal biological functions...
Aortic aneurysm is a common cardiovascular disease characterised by continuous dilation of the aorta, and this places heavy burden on healthcare worldwide. Few drugs have been suggested to be effective in controlling progression aortic aneurysms. Preclinical drug responses from traditional cell culture animals are usually controversial. An vitro model great demand for successful screening. In study, we induced an microphysiological system test metformin, which potential treatment Human...
Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristoylation sites (SRMS) is a non-receptor that has been found to be overexpressed in various tumors. However, the role of SRMS colorectal cancer (CRC) not well established.We evaluated expression levels CRC using GEPIA, Oncomine, HPA datasets. Survival information gene data were obtained from The Cancer Genome Atlas (TCGA). Then, association between clinicopathological features was analyzed UALCAN dataset....
This study investigated the effect of enzymatic deamidation on physicochemical properties and functionality AWPI. Deamidation increased surface charge modified hydrophobicity AWPI, resulting in a remarkable improvement solubility. Furthermore, emulsifying deamidated AWPI were greatly influenced by degree. The capacity walnut protein, specifically at 0.25 h (DeWPI0.25) 9 (DeWPI9), to stabilize low internal phase high emulsions (LIPEs HIPEs) was evaluated. LIPEs stabilized DeWPI0.25 exhibited...
邓辉 1)** 张运丽 钟白云 1)*** 刘蔚东 2) 晏群 1) 冯斯斯 肖志强 3)2DElite 分析软件进行图像分析，基质辅助激光解吸电离飞行时间质谱(matrix-assistedlaserdesorption/ionizationtimeofflight massspectrometry,MALDI-TOF-MS)得到相应的肽质量指纹图(peptidemassfingerprint,PMF)，搜索数据库鉴定差异蛋白． 建 立了亚健康便秘人群及健康志愿者结肠黏膜组织 2-DE 图谱，分析出其凝胶的平均蛋白质点数(501.00依 37.16，536.00依 41.63), 两者平均差异蛋白质点数为 46.00依7.82，取20 个表达量明显改变的蛋白质点进行质谱分析，鉴定出 17 个蛋白质． 其中 7 个 蛋白质点表达下调，10 个蛋白质点表达上调． 差异蛋白质点包括蛋白质合成与分解、分子伴侣、氧化还原调节及信号传导 等相关蛋白质． 随即应用免疫印迹(Westernblot)技术分析差异蛋白 茁-actin、YWHAZ 及 PBP-玉(phosphatidylethanolamine
To determine the effect of esketamine in patient-controlled analgaesia after hip replacement on postoperative pain and improve sleep quality patients.
Alkaline-extracted walnut protein isolates (WPI) exhibit limited solubility, which poses challenges for their application in the food industry. The present study investigated effects of protein-glutaminase (PG) deamidation on physicochemical characteristics, solubility and emulsifying properties WPI.