A5101510896- Photoreceptor and optogenetics research
- Pluripotent Stem Cells Research
- Developmental Biology and Gene Regulation
- Neuroscience and Neuropharmacology Research
- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Wnt/β-catenin signaling in development and cancer
- Atmospheric chemistry and aerosols
- RNA Interference and Gene Delivery
- Congenital heart defects research
- Cancer-related gene regulation
- Lipid Membrane Structure and Behavior
- Advanced NMR Techniques and Applications
- Liver physiology and pathology
- Pancreatic function and diabetes
- Ubiquitin and proteasome pathways
- Muscle Physiology and Disorders
- CRISPR and Genetic Engineering
- Genomics and Chromatin Dynamics
- Photosynthetic Processes and Mechanisms
- RNA modifications and cancer
- Renal and related cancers
- Neural dynamics and brain function
- RNA Research and Splicing
- ATP Synthase and ATPases Research
Capital Medical University
2025
Beijing Ditan Hospital
2025
Chinese Academy of Sciences
2013-2024
University of Chinese Academy of Sciences
2018-2024
Qingdao University
2019-2024
Fujian Institute of Research on the Structure of Matter
2024
Tan Kah Kee Innovation Laboratory
2024
Qingdao Women and Children's Hospital
2024
Center for Excellence in Molecular Cell Science
2011-2023
Institute of Soil Science
2020-2023
Epithelial-mesenchymal transition (EMT) is a physiological process that has been recognized to occur during the progression of an increasingly large number human diseases, including liver fibrosis, cirrhosis, and hepatocellular carcinoma. The activation transforming growth factor β (TGF-β) signaling considered critical event EMT, efforts have made screen small molecules interfere with TGF-β pathway EMT. Here we report identification sorafenib, clinical agent inhibits signaling. When applied...
Idiopathic pulmonary fibrosis (IPF) is a serious progressive and irreversible lung disease with unknown etiology few treatment options. This was once thought to be chronic inflammatory-driven process, but it increasingly recognized that the epithelial–mesenchymal transition (EMT) contributes cellular origin of fibroblast accumulation in response injury. During pathogenesis fibrotic diseases, transforming growth factor-β (TGF-β) signaling considered pivotal inducer EMT activation, number...
Keloid disease is characterized by hyperproliferation of responsive fibroblasts with vigorously continuous synthesis extracellular matrix (ECM) components. Although the process which keloids develop poorly understood, most theories etiology are referred to fibroblast dysfunction. A central event in dermal repair release growth factors response skin injury, leads dysregulation several crucial pathways that initiate activation keloid (KFs) and promote ECM accumulation. Hence, strategies aimed...
<p indent="0mm">Intrahepatic cholangiocarcinoma (ICC) accounts for approximately 15% of primary liver cancers, and the incidence rate has been increasing in recent years. Surgical resection is best treatment ICC, but 5-year survival less than 30%. ICC signature genes are crucial early diagnosis so it especially important to identify genes. The aim this study screen find potential target ICC. We that UBA3 highly expressed knockdown <italic>UBA3</italic> inhibits proliferation, invasion...
Abstract Background Novel therapeutic targets are urgently needed for treating drug-resistant non-small cell lung cancer (NSCLC) and overcoming drug resistance to molecular-targeted therapies. Regulator of G protein signaling 20 (RGS20) is identified as an upregulated factor in many cancers, yet its specific role the mechanism through which RGS20 functions NSCLC remain unclear. Our study aimed identify prognosis delineate associated cellular molecular pathways. Methods Immunohistochemistry...
The CRAFITY score is mainly utilized for hepatocellular carcinoma (HCC) patients receiving atezolizumab and bevacizumab, with little investigation in its predictive capacity alternative regimens, such as lenvatinib programmed cell death protein 1 (PD-1) inhibitors, which are widely Chinese clinical practice. To look at the significance of HCC taking PD-1 inhibitors. retrospective consisted 192 incurable who received inhibitors between January 2018 2022. Patients were stratified according to...
Understanding the interplay between farming system and soil microbiomes could aid design of a sustainable efficient system. A comparative greenhouse experiment consisting organic (ORG), integrated (INT) conventional (CON) systems was established in northern China 2002. The effects 12 years on were explored by metagenomic 16S rRNA gene amplicon sequencing analyses. Long-term ORG shifted community composition dominant phyla, especially Acidobacteria, increased relative abundance Ignavibacteria...
Researches validate that circular RNAs (circRNAs) are dysregulated in a variety of malignancies and play an important role regulating the malignant phenotype tumor cells. Nevertheless, circ_0000527 retinoblastoma (RB) its regulatory mechanisms remain largely unknown.Real-time PCR (RT-PCR) was used to detect miR-646 expression RB tissues The LRP6 cells detected by Western blot. relationship between clinicopathological parameters patients analyzed. Cell proliferation, apoptosis metastasis were...
Abstract Background Intrahepatic cholangiocarcinoma (ICC) accounts for about 15% of primary liver cancer, and the incidence rate has been rising in recent years. Surgical resection is best treatment ICC, but 5-year survival less than 30%. ICC signature genes are crucial early diagnosis so it especially important to find its therapeutic drug. Here, we studied that bufalin targeting CAMKK2 promotes mitochondrial dysfunction inhibits occurrence metastasis intrahepatic through Wnt/β-catenin...