A5053906669- Photoacoustic and Ultrasonic Imaging
- Optical Imaging and Spectroscopy Techniques
- Thermography and Photoacoustic Techniques
- Pluripotent Stem Cells Research
- Epigenetics and DNA Methylation
- Infrared Thermography in Medicine
- PAPR reduction in OFDM
- Histone Deacetylase Inhibitors Research
- Power Line Communications and Noise
- Cancer-related molecular mechanisms research
- Pharmaceutical Economics and Policy
- Cytomegalovirus and herpesvirus research
- Advanced X-ray and CT Imaging
- RNA modifications and cancer
- Economic and Financial Impacts of Cancer
- Telomeres, Telomerase, and Senescence
- Radiation Dose and Imaging
- Spectroscopy Techniques in Biomedical and Chemical Research
- Infrared Target Detection Methodologies
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Image Fusion Techniques
- Ultrasound Imaging and Elastography
- Pancreatic function and diabetes
- Radiation Therapy and Dosimetry
- Amino Acid Enzymes and Metabolism
Fudan University
2024-2025
Pudong Medical Center
2025
Heilongjiang University
2024
Second Affiliated Hospital of Nanjing Medical University
2019-2024
Hunan University of Traditional Chinese Medicine
2023
The Wistar Institute
2017-2022
Shanghai University
2021
Nanjing University
2021
Chinese Academy of Sciences
2010-2020
Aerospace Information Research Institute
2020
The theoretical underpinnings of photoacoustic ultrasound (PAUS) reconstruction tomography are presented. A formal relationship between PAUS signals and the heterogeneous distribution optical absorption within object being investigated is developed. Based on this theory, a approach, analogous to that used in x‐ray computed tomography, suggested. Initial experimental results suggest approach produces “reasonable” reconstructions for absorbers distributed narrow plane embedded highly scattering medium.
Abstract Despite the high initial response rates to PARP inhibitors (PARPi) in BRCA-mutated epithelial ovarian cancers (EOC), PARPi resistance remains a major challenge. Chemical modifications of RNAs have emerged as new layer epigenetic gene regulation. N6-methyladenosine (m6A) is most abundant chemical modification mRNA, yet role m6A has not previously been explored. Here, we show that FZD10 mRNA contributes by upregulating Wnt/β-catenin pathway EOC cells. Global profile revealed...
Bone morphogenetic protein (BMP) signaling plays a crucial role in maintaining the pluripotency of mouse embryonic stem cells (ESCs) and has negative effects on ESC neural differentiation. However, it remains unclear when how BMP executes those different functions during commitment. Here, we show that BMP4-sensitive window exists Cells at this specific period correspond to egg cylinder stage epiblast can be maintained as ESC-derived (ESD-EpiSCs), which have same characteristics EpiSCs...
Abstract Cyclic cGMP-AMP synthase (cGAS) is a pattern recognition cytosolic DNA sensor that essential for cellular senescence. cGAS promotes inflammatory senescence-associated secretory phenotype (SASP) through recognizing cytoplasmic chromatin during cGAS-mediated inflammation the antitumor effects of immune checkpoint blockade. However, mechanism by which recognizes unknown. Here we show topoisomerase 1-DNA covalent cleavage complex (TOP1cc) both necessary and sufficient SASP TOP1cc...
Senescence-associated secretory phenotype (SASP) mediates the biological effects of senescent cells on tissue microenvironment and contributes to ageing-associated disease progression. ACSS2 produces acetyl-CoA from acetate epigenetically controls gene expression through histone acetylation under various circumstances. However, whether how regulates cellular senescence remains unclear. Here, we show that pharmacological inhibition deletion Acss2 in mice blunts SASP abrogates pro-tumorigenic...
Theoretical predictions and experimental measurements of photoacoustic pulse production within a 0.5% solution Liposyn, highly scattering, optical propagation medium, are reported. A simple model for energetics is developed that predicts signal pressure as function depth turbid medium following surface irradiation from an infrared source. The valid very short duration. the acoustic produced at distance r center small, absorbing sphere radius R consists two, opposite polarity pulses, one...
Abstract Induction of definitive endoderm (DE) cells is a prerequisite for the whole process embryonic stem (ES) differentiating into hepatic or pancreatic progenitor cells. We have established an efficient method to induce mouse ES cell‐derived DE in suspension body (EB) culture. Similar previous studies, cells, which were defined as Cxcr4 + c‐Kit , E‐cadherin PDGFRa − could be induced serum‐free EBs at Day 4 induction. The activations Wnt, Nodal, and FGF signaling pathways promoted cell...
Cell fate determination requires the cooperation between extrinsic signals and intrinsic molecules including transcription factors as well epigenetic regulators. Nevertheless, how neural commitment is regulated by modifications remains largely unclear. Here we show that transient histone deacetylation at epiblast stage promotes differentiation of mouse embryonic stem cells (mESCs). Histone deacetylase 1 (HDAC1) deficiency in mESCs partially phenocopies inhibition vitro, displays reduced...
The ectoderm has the capability to generate epidermis and neuroectoderm plays imperative roles during early embryonic development. Our recent study uncovered a region with ectodermal progenitor potential in mouse embryo at day 7.0 revealed that Nodal inhibition is essential for its formation. Here, we demonstrate through brief of signaling vitro, stem cell (ESC)-derived epiblast cells (ESD-EpiSCs) could be committed transient populations, which possess ability give rise neural or epidermal...
A new scattering phase function is presented to approximate the accurate from Mie theory. The demonstrates much better agreement with theory for biomedical media (with mean cosine of angles g>0.8) than Henyey-Greenstein function, which has been widely adopted by researchers in optics field. Using as integral kernel radiative transport equation, an analytical result term equation obtained highly aligned beams. This may lead a semi-analytical solution time-dependent time-resolved spectroscopy.
Long-lived plants face the challenge of ever-increasing mutational burden across their long lifespan. Early sequestration meristematic stem cells is supposed to efficiently slow down this process, but direct measurement somatic mutations that accompanies segregated cell lineages in still rare. Here, we tracked 33 leaves and 22 adventitious roots from stem-cuttings eight major branches a shrub willow (Salix suchowensis). We found most propagated separately roots, providing clear evidence for...
Abstract Bromodomain and extra-terminal domain (BET) proteins, which function partly through MYC proto-oncogene (MYC), are critical epigenetic readers emerging therapeutic targets in cancer. Whether how BET inhibition simultaneously induces metabolic remodeling cancer cells remains unclear. Here we find that even transient by JQ-1 other pan-BET inhibitors (pan-BETis) blunts liver cell proliferation tumor growth. decreases glycolytic gene expression but enhances mitochondrial glucose...
Dementia is more prevalent in women than men across the world, and sex differences are reflected burden of dementia borne by men. However, a few studies have specifically analyzed disease Chinese women.This article aims to raise awareness females with (CFWD), outline an effective response future trends China from female perspective, provide reference for scientific formulation prevention treatment policies China.In this article, epidemiological data on were obtained Global Burden Disease...
Photoacoustic imaging is a new modality which converts pressure signals received by an array of transducers to regional distribution electromagnetic absorption density. This paper presents rigorous theory for photoacoustic image reconstruction in concise format. A type transform, the P-transform, proposed, analysed and presented as main mathematical tool reconstruction. It proved that intrinsically three-dimensional (3D) procedure. The spatial smear function (SSF) introduced. To complete...
Photoacoustic imaging theory is presented based on fundamental physical processes involved in photoacoustic phenomena. Excessive pressure used to characterize the signal. A solution derived for liquids investigated under a rapid heating condition. image reconstruction proposed short, square pulses. The limitation of discussed. Relationship and Radon transform presented. local radiation absorption energy density determined by three- two- dimensional cases complete or partial data acquisition....
The purpose of this study is to develop automatic algorithms for the segmentation phase radiotherapy treatment planning. We new image processing techniques that are based on solving a partial diferential equation evolution curve identifies segmented organ. velocity function piecewise Mumford-Shah functional. Our method incorporates information about target organ into classical algorithms. This information, which given in terms three- dimensional wireframe representation organ, serves as an...
A computerized fluoroscopy method for isolating low fluoroscopic image contrast, which results during the flow of iodinated contrast materials through cardiovascular structures is described. This technique requires applying one a family recursive filtering algorithms have been designed to isolate time varying contrast. Applications this intravenous angiography are Hardware implementation these also described and preliminary on human subjects presented.