A5101406880- Spinal Fractures and Fixation Techniques
- Head and Neck Cancer Studies
- Pelvic and Acetabular Injuries
- Scoliosis diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- Photodynamic Therapy Research Studies
- Spinal Dysraphism and Malformations
- Skin Protection and Aging
- Dermatologic Treatments and Research
- Cervical Cancer and HPV Research
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Spondyloarthritis Studies and Treatments
- Parasites and Host Interactions
- Facial Rejuvenation and Surgery Techniques
- Infectious Diseases and Tuberculosis
- Acne and Rosacea Treatments and Effects
- Reconstructive Surgery and Microvascular Techniques
- Colorectal and Anal Carcinomas
- Phytochemicals and Antioxidant Activities
- Neutropenia and Cancer Infections
- Gastric Cancer Management and Outcomes
- Cervical and Thoracic Myelopathy
- Cancer therapeutics and mechanisms
Xi'an Honghui Hospital
2013-2025
Xi'an Jiaotong University
2013-2025
Shangluo University
2025
Nantong University
2018-2024
China Pharmaceutical University
2023-2024
Ningbo No. 2 Hospital
2024
International Peace Maternity & Child Health Hospital
2021-2024
Shanghai Jiao Tong University
2021-2024
Yunnan University
2022-2023
Dali University
2022-2023
Abstract Introduction Paclitaxel (Taxol ® ) is a microtubule-targeted agent that widely used for cancer treatment. However, resistance to paclitaxel frequently encountered in the clinic. There increasing interest identifying compounds may increase sensitivity conventional chemotherapeutic agents. In this study, we investigated whether green tea polyphenol (-)-epigallocatechin gallate (EGCG) could sensitize breast carcinoma vivo . Methods Breast cells were treated with or without EGCG and...
Th17 cells and interleukin-17 (IL-17) have been found to play an important role in the pathology of multiple sclerosis (MS) its animal model, experimental autoimmune encephalomyelitis (EAE). Response IL-17, reactive astrocytes accompany with immune infiltration axonal damage MS/EAE. However, regulatory mechanism IL-17-activated inflammation EAE process still remain largely unknown. Here, we elucidated that miR-409-3p miR-1896, as co-upregulated microRNAs activated mice, targeted suppressor...
To explore the risk factors of bone cement displacement after percutaneous vertebral augmentation (PVA) in patients with osteoporotic compression fracture (OVCF). We retrospectively reviewed records 1,538 OVCF treated vertebroplasty (PVP) or (PKP) from January 2016 to June 2021. Patients were divided into group (n = 78) and non-displacement 1,460) according radiographic images. Possible for noted, including age, gender, body mass index (BMI), mineral density (BMD), underlying disease, number...
Ferroptosis is a novel form of oxidative cell death triggered by iron-dependent lipid peroxidation. The induction ferroptosis presents an attractive therapeutic strategy for human diseases, such as prostate cancer and breast cancer. Herein, we describe our design, synthesis, biological evaluation endogenous glutathione peroxidase 4 (GPX4) degraders using the proteolysis targeting chimera (PROTAC) approach with aim inducing in cells. Our efforts led to discovery compound
A novel glucomannan, named ATSW-1, was obtained from Allii Tuberosi Semen by ion and gel permeation chromatography purification. Its structure characterized using high-performance chromatography, Fourier transform infrared spectroscopy, gas chromatography-mass spectrometry, nuclear magnetic resonance spectroscopy. The in vitro immune activities of ATSW-1 were examined the Cell Counting Kit-8, neutral red phagocytosis assay, secretion related cytokines. results showed that molecular weight...
To describe the clinical and radiographic outcomes of patients with severe post-tubercular kyphosis (PTK) in adults who underwent modified posterior vertebral column resection (mPVCR). A retrospective analysis was conducted on data from 22 PTK surgical treatment. All received a one-stage mPVCR deformity correction. General information, radiological parameters including angle (KA) sagittal vertical axis (SVA), functional America Spinal Injury Association (ASIA) grades, Oswestry Disability...
Hepatic steatosis is a major health issue that can be attenuated by healthy diet. This study investigates the effects and molecular mechanisms of butyrate, dietary fiber metabolite gut microbiota, on lipid metabolism in hepatocytes.
Abstract Low‐dose 5‐aminolevulinic acid photodynamic therapy (ALA‐PDT) has been used to cope with skin photoaging, and is thought involve DNA damage repair responses. However, it still unknown how low‐dose ALA‐PDT regulates curb photoaging. We established a photoaging model using human dermal fibroblasts (HDFs) rat skin. RNA‐sequencing (RNA‐seq) analysis was conducted identify differentially expressed genes (DEGs) in HDFs before after treatment, followed by bioinformatics analysis....
Retrospective clinical study.The aim of this study was to evaluate retrospectively the safety and efficacy 1-stage surgical treatment 45 consecutive patients, who had progressive congenital spinal deformity associated with split cord malformation (SSCM).For correction SSCM, it has been reported that all SSCM should be operated on before any orthopedic intervention, then surgery for stabilization performed 3 6 months later. Recently, different viewpoints have approved, common these 2...
Abstract Circular RNA (circRNA) is a class of noncoding that regulates the activity microRNAs and gene expression. Altered circRNA expression associated with human diseases. The present study profiled differentially expressed circRNAs in ultraviolet B stress‐induced fibroblast premature senescence (UVB‐SIPS) model, assessed role circRNA_100797 UVB‐SIPS. UVB‐SIPS model was confirmed by ß‐galactosidase staining, cell viability CCK‐8 assay, flow cytometric cycle distribution subjected to chip...
Fractional CO2 laser is therapeutic for acne atrophic scar, but its effect usually limited after multiple sessions, with occasional adverse reactions. This study aimed to evaluate the efficacy and safety of a new modality combining ultra-pulse fractional (multiple mode procedures [MMP]) in treatment scars.From December 2017 January 2023, total 103 patients facial scars treated MMP technique were retrospectively analyzed. was performed 1-4 sessions an interval approximately three months....
Abstract Objective To analyze the clinical efficacy and safety of fractional microneedle radiofrequency (FMR) for facial atrophic acne scars in a real‐world setting. Methods The data patients with who had received FMR therapy from February 2018 to August 2022 were retrospectively analyzed. improvement was assessed using ECCA Grading Scale (échelle d'évaluation clinique des cicatrices d'acné), Global Aesthetic Improvement (GAIS), modified Manchester Scar (mMSS). Adverse reactions during...
The multikinase inhibitor sorafenib is a first-line drug for advanced hepatocellular carcinoma. response to varies among carcinoma patients and many of the responders suffer from reduced sensitivity after long-term treatment. This study aims explore novel strategy potentiate or maximize anti-hepatocellular effects sorafenib.We used cell lines, western blotting, various antagonists, siRNA tumour xenografts mouse model determine anti- in combination with berbamine other Na+ /K+ -ATPase...
A substitution mutation of valine to phenylalanine at codon encoding position 617 the Janus kinase 2 ( JAK2 ) gene V617F has been detected in myeloid cells some individuals with higher levels proinflammatory cytokine production such as interleukin (IL)-6. However, mechanisms by which mediating those cytokines remain unclear. We, therefore, established -expressing murine macrophages macrophages) and found that p-STAT3 were markedly elevated association an increase IL-6 production. inhibition...
Exosomal microRNAs have been investigated in bystander effect, but it is unclear whether microRNA works ultraviolet radiation–induced effects (UV-RIBEs) and what the underlying mechanism could be. Exosomes from (UV)–irradiated human skin fibroblasts (HSFs) were isolated transferred to normal HSFs, followed by detection of proliferation rate, oxidative damage level, apoptosis rate. miRNAs evaluated screened with miRNA sequencing quantitative reverse transcriptase–polymerase chain reaction...