A5080625732- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Cancer-related molecular mechanisms research
- Histiocytic Disorders and Treatments
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Toxoplasma gondii Research Studies
- MicroRNA in disease regulation
- Virus-based gene therapy research
- Circular RNAs in diseases
- HIV Research and Treatment
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Adenosine and Purinergic Signaling
- Parvovirus B19 Infection Studies
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- T-cell and Retrovirus Studies
- Medicinal Plants and Bioactive Compounds
- vaccines and immunoinformatics approaches
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Multiple Sclerosis Research Studies
- Mycobacterium research and diagnosis
Xuzhou Medical College
2013-2024
Beijing Hospital of Traditional Chinese Medicine
2023
Capital Medical University
2023
Beijing University of Chinese Medicine
2023
Nanjing Medical University
2007-2020
Kaposi’s sarcoma (KS)-associated herpesvirus (KSHV) is etiologically associated with KS, the most common AIDS-related malignancy. KS characterized by vast angiogenesis and hyperproliferative spindle cells. We have previously reported that HIV-1 Tat can trigger KSHV reactivation accelerate Kaposin A-induced tumorigenesis. Here, we explored promotion of vIL-6-induced promotes cell proliferation, cellular transformation, vascular tube formation VEGF production in culture. enhances tumorigenesis...
Abstract Kaposi's sarcoma (KS) is an AIDS-defining cancer with aberrant neovascularization caused by KS-associated herpesvirus (KSHV). Although the interaction between HIV-1 and KSHV plays a pivotal role in promoting aggressive manifestations of KS, pathogenesis underlying AIDS-KS remains largely unknown. Here we examined Nef protein promotion oncoprotein K1-induced angiogenesis. We showed that both internalized ectopic expression endothelial cells synergized K1 to facilitate vascular tube...
Th17 cells and interleukin-17 (IL-17) have been found to play an important role in the pathology of multiple sclerosis (MS) its animal model, experimental autoimmune encephalomyelitis (EAE). Response IL-17, reactive astrocytes accompany with immune infiltration axonal damage MS/EAE. However, regulatory mechanism IL-17-activated inflammation EAE process still remain largely unknown. Here, we elucidated that miR-409-3p miR-1896, as co-upregulated microRNAs activated mice, targeted suppressor...
Co-infection with HIV-1 and Kaposi's sarcoma-associated herpesvirus (KSHV) is the cause of aggressive AIDS-related sarcoma (AIDS-KS) characterized by abnormal angiogenesis. The impact KSHV interaction on pathogenesis extensive angiogenesis AIDS-KS remains unclear. Here, we explored synergistic effect Tat oncogene Orf-K1 Our results showed that soluble or ectopic expression enhanced K1-induced cell proliferation, microtubule formation in chorioallantoic membrane nude mice models. Mechanistic...
The etiology of glioma remains unclear so far. Human herpesvirus 6 (HHV-6) might be associated with glioma, but there is no direct evidence to support this. High percentages HHV-6 DNA and protein were detected in tissue from gliomas, compared normal brain tissue. In addition, a strain HHV-6A was isolated the fluid specimens cysts. levels interleukin (IL-6), 8 (IL-8), tumor necrosis factor α, transforming growth β (TGF-β) cyst HHV-6–positive patients glioma. Furthermore, infection promoted...
HIV-associated neurocognitive disorders (HANDs) afflict more than half of HIV-1-positive individuals. The transactivator transcription (Tat) produced by HIV virus elicits inflammatory process and is a major neurotoxic mediator that induce neuron damage during HAND pathogenesis. Activated astrocytes are important cells involved in neuroinflammation neuronal damage. Purinergic receptors expressed participate positive feedback loop virus-induced neurotoxicity. Here, we investigated whether...
Abstract Papillary thyroid cancer (PTC) accounts for 80% of all cancers and seriously impacts the quality people's lives. Long noncoding RNAs (lncRNAs) play an important role in PTC. In previous studies, thousands lncRNAs were screened to study their potential relationships with The aim this was investigate effect RPL34‐AS1 PTC explore its mechanisms. Bioinformatic analyses performed characterize possible function biological features RPL34‐AS1. Apoptosis, proliferation, invasion detected...
ABSTRACT Human herpesvirus 6 (HHV-6) is an important immunosuppressive and immunomodulatory virus that primarily infects immune cells strongly suppresses the proliferation of infected cells. However, mechanisms responsible for regulation suppression mediated by HHV-6 are still unknown. In this study, we examined ability HHV-6A to manipulate cell cycle progression in explored potential molecular mechanisms. We demonstrated infection with imposed a growth-inhibitory effect on HSB-2 inducing...
Interleukin 9 (IL-9), produced mainly by T helper (Th9) cells, has been recognized as an important regulator in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Astrocytes respond to IL-9 reactive astrocytes always associate with blood-brain barrier damage, immune cell infiltration, spinal injury MS EAE. Several long non-coding RNAs (lncRNAs) aberrant expression have identified the pathogenesis of MS. Here, we examined effects lncRNA Gm13568 (a...
HIV-associated neurocognitive disorder (HAND) is a neurodegenerative disease associated with persistent neuroinflammation and subsequent neuron damage. Pro-inflammatory factors neurotoxins from activated astrocytes by HIV-1 itself its encoded proteins, including the negative factor (Nef), are involved in pathogenesis of HAND. This study was designed to find potential lncRNAs that regulate astrocyte functions inflammation process. We performed microarray analysis primary mouse treated Nef...
Background Autoimmune encephalitis is a neurological condition caused by abnormal immune responses, manifesting as cognitive impairments, behavioral abnormalities, and seizures. Its diagnosis depends on the detecting neuronal surface antibodies in serum or cerebrospinal fluid. Despite recent advances understanding, clinical recognition remains challenging, especially with rare such anti-dopamine D2 receptor (D2R) anti-dipeptidyl-peptidase-like protein 6 (DPPX) antibodies. Delayed can lead to...
ABSTRACT Human herpesvirus 6 (HHV-6) is an important immunosuppressive and immunomodulatory virus. The mechanisms by which HHV-6 establishes latency immunosuppression in its host are not well understood. Here we characterized HHV-6-specific T cells peripheral blood mononuclear (PBMCs) from HHV-6-infected donors. Our results showed that infection could induce both CD4 + CD8 regulatory (Treg) cells. These Treg had potent suppressive activity expressed high levels of Treg-associated molecules...
Abstract Human herpesvirus‐6 (HHV‐6) infection normally persists for the lifetime of host and may reactivate with immunosuppression. The mechanism behind HHV‐6 latent is still not fully understood. In this study, we observed that decreased proliferation CD4 + T cells PBMCs but CD8 from HHV‐6‐infected individuals was stimulated cell lysates. Moreover, HHV‐6‐stimulated have suppressive activity on naïve HHV‐6‐uninfected individuals. However, no increased proportion CD25 Treg contributed to...
Abstract Background Human herpesvirus 6 (HHV-6) is a T-lymphtropic and neurotropic virus that can infect various types of cells. Sequential studies reported apoptosis glia neurons induced by HHV-6 might act potential trigger for some central nervous system (CNS) diseases. involved in the pathogenesis encephalitis, multiple sclerosis (MS) fatigue syndrome. However, mechanisms responsible infected CNS cells are poorly understood. In this study, we investigated cell death processes primary...
Background/Aims: Multiple sclerosis (MS) is an autoimmune disease in the central nervous system associated with demyelination and axonal injury. Astrocyte activation involved pathogenesis of MS experimental encephalomyelitis (EAE), animal model MS. This study was designed to find potential lncRNAs EAE mice activated astrocytes. Methods: we performed microarray analysis from brain tissues primary mouse astrocytes treated IL-9(50 ng/ml). 12 were validated through real-time PCR. Gene ontology...
Abstract The pro‐inflammatory cytokine interleukin 17 (IL‐17), that is mainly produced by Th17 cells, has been recognized as a key regulator in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Reactive astrocytes stimulated proinflammatory cytokines including IL‐17 are involved blood brain barrier destruction, inflammatory cells infiltration spinal cord injury. However, the role of long non‐coding RNAs (lncRNAs) induced pathogenesis MS EAE remains unknown. Herein,...
Abstract Human herpesvirus 6 (HHV‐6) is a beta‐herpesvirus capable of infecting cells from different origin. In this study, infection with HHV‐6A human embryonic fibroblasts (HEFs) was performed. Infected showed obvious cytopathic effects (CPE). PCR and immunohistochemical tests also confirmed that HEFs are susceptible to infection. The biological on were studied. decreased proliferation as measured by [ 3 H] thymidine incorporation cell counting. Further analysis demonstrated leads cycle...
Abstract The present study aimed to investigate the function of long non-coding RNA HEIH in gastric carcinoma (GC). Adjacent normal tissues and GC were obtained from 72 patients. Real-time quantitative polymerase chain reaction (RT-qPCR) was utilized measure expression cancer cells. Cell Counting Kit-8 transwell assays employed evaluate cell proliferation, migration invasion. An Annexin V-fluorescein-isothiocyanate (FITC)/propidium iodide (PI) Apoptosis Detection Kit used apoptosis ratio....