A5010638598- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Tryptophan and brain disorders
- Gut microbiota and health
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical Analysis and Sensing Techniques
- Receptor Mechanisms and Signaling
- Crystallography and molecular interactions
- Lung Cancer Treatments and Mutations
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Ginseng Biological Effects and Applications
- Lung Cancer Diagnosis and Treatment
- Nutritional Studies and Diet
- Gastrointestinal motility and disorders
- Cancer Immunotherapy and Biomarkers
- Sulfur Compounds in Biology
- Tea Polyphenols and Effects
- Eating Disorders and Behaviors
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
Tianjin Medical University
2025
Shuguang Hospital
2025
Shanghai University of Traditional Chinese Medicine
2025
Quzhou City People's Hospital
2025
Shenzhen Institutes of Advanced Technology
2025
Chinese Academy of Sciences
2025
Xuzhou Medical College
2016-2024
University of Wollongong
2015-2024
Illawarra Health and Medical Research Institute
2014-2024
Shanghai Jiao Tong University
2016-2023
Neuroinflammation plays an important role in the onset and progression of neurodegenerative diseases such as Alzheimer's disease. Lipopolysaccharide (LPS, endotoxin) levels are higher brains disease patients associated with neuroinflammation cognitive decline, while neural cholinergic signaling controls inflammation. This study aimed to examine efficacy galantamine, a clinically approved agent, alleviating LPS-induced decline well mechanism. Mice were treated galantamine (4 mg/kg,...
"Western" style dietary patterns are characterized by a high proportion of highly processed foods rich in fat and low fiber. This diet pattern is associated with myriad metabolic dysfunctions, including neuroinflammation cognitive impairment. β-glucan, the major soluble fiber oat barley grains, fermented lower gastrointestinal tract, potentially impacting microbial ecosystem thus may improve elements cognition brain function via gut-brain axis. The present study aimed to evaluate effect...
Abstract Background Cognitive impairment, an increasing mental health issue, is a core feature of the aging brain and neurodegenerative diseases. Industrialized nations especially, have experienced marked decrease in dietary fiber intake, but potential mechanism linking low intake cognitive impairment poorly understood. Emerging research reported that diversity gut microbiota Western populations significantly reduced. However, it unknown whether fiber-deficient diet (which alters microbiota)...
Obesity is a risk factor for neurodegenerative disease associated with cognitive dysfunction, including Alzheimer's disease. Low-grade inflammation common in obesity, but the mechanism between and impairment obesity unclear. Accumulative evidence shows that quinolinic acid (QA), neuroinflammatory neurotoxin, involved pathogenesis of processes. We investigated role QA obesity-induced beneficial effect butyrate counteracting impairments cognition, neural morphology, signaling. show human there...
Gut homeostasis, including intestinal immunity and microbiome, is essential for cognitive function via the gut-brain axis. This axis altered in high-fat diet (HFD)-induced impairment closely associated with neurodegenerative diseases. Dimethyl itaconate (DI) an derivative has recently attracted extensive interest due to its anti-inflammatory effect. study investigated whether intraperitoneal administration of DI improves prevents deficits HF diet-fed mice.DI effectively attenuated...
Context Oxidative stress and inflammation are implicated in the aging process its related hepatic renal function decline. Chlorogenic acid (CGA) is one of most abundant polyphenol compounds human diet. Recently, CGA has shown vivo vitro antioxidant properties.Objective The current study investigates effects protective chlorogenic on d-galactose-induced liver kidney injury.Materials methods Hepatic injuries were induced a mouse model by subcutaneously injection d-galactose (d-gal; 100 mg/kg)...
Abstract Background Western pattern diets induce neuroinflammation and impair cognitive behavior in humans animals. Neuroinflammation impairment have been associated with microbiota dysbiosis, through the gut-brain axis. Furthermore, microbiota-accessible carbohydrates (MACs) found dietary fiber are important shaping microbial ecosystem potential to improve gut-brain-axis. However, effects of MACs on cognition an obese condition not yet investigated. The present study aimed evaluate effect...
The microbiota–gut–liver axis has emerged as an important player in developing nonalcoholic steatohepatitis (NASH), a type of fatty liver disease (NAFLD). Higher mushroom intake is negatively associated with the prevalence NAFLD. This study examined whether lentinan, active ingredient mushrooms, could improve NAFLD and gut microbiota dysbiosis mice induced by high-fat (HF) diet. Dietary lentinan supplementation for 15 weeks significantly improved HF mice, evidenced increased abundance phylum...
JOURNAL/nrgr/04.03/01300535-202409000-00042/figure1/v/2024-01-30T062302Z/r/image-tiff Parkinson's disease is a neurodegenerative characterized by motor and gastrointestinal dysfunction. Gastrointestinal dysfunction can precede the onset of symptoms several years. Gut microbiota dysbiosis involved in pathogenesis disease, whether it plays causal role dysfunction, mechanism underlying this potential effect, remain unknown. CCAAT/enhancer binding protein β/asparagine endopeptidase (C/EBPβ/AEP)...
A low-grade pro-inflammatory state is at the pathogenic core of obesity and type 2 diabetes. We tested hypothesis that plant terpenoid compound ginsenoside Rb1 (Rb1), known to exert anti-inflammatory effects, would ameliorate obesity, obesity-associated inflammation glucose intolerance in high-fat diet-induced obese mouse model. Furthermore, we examined effect treatment on central leptin sensitivity signaling pathway hypothalamus. found intraperitoneal injections (14 mg/kg, daily) for 21...
Alzheimer's disease (AD) is a neurodegenerative disorder, characterized by progressive loss of memory and cognitive function, associated with the deficiency synaptic acetylcholine, as well chronic neuroinflmmation. Tacrine, potent acetylcholinesterase (AChE) inhibitor, was previously prescribed clinical therapeutic agent for AD, but it recently withdrawn because caused widespread hepatotoxicity. Hydrogen sulfide (H2S) has neuroprotective, hepatoprotective, anti-inflammatory effects. In this...
Abstract Background Long-term high fat (HF) diet intake can cause neuroinflammation and cognitive decline through the gut-brain axis. (1, 3)/(1, 6)-β-glucan, an edible polysaccharide isolated from medical mushroom, Lentinula edodes ( L. ), has potential to remodel gut microbiota. However, effects of derived β-glucan against HF diet-induced remain unknown. This study aimed evaluate neuroprotective effect mechanism dietary L supplementation obesity-associated in mice fed by a diet. Methods...
Background Chronic infection with the neurotropic parasite Toxoplasma gondii (T. gondii) can cause anxiety and gut microbiota dysbiosis in hosts. However, potential role of induced by remains unclear.