A5001487848- Protein Kinase Regulation and GTPase Signaling
- Fungal and yeast genetics research
- DNA Repair Mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Circadian rhythm and melatonin
- Gut microbiota and health
- Parasites and Host Interactions
- Heat shock proteins research
- Melanoma and MAPK Pathways
- Biological Activity of Diterpenoids and Biflavonoids
- Endoplasmic Reticulum Stress and Disease
- Plant Gene Expression Analysis
- Genomics and Chromatin Dynamics
- Natural product bioactivities and synthesis
- Genetics, Aging, and Longevity in Model Organisms
- RNA and protein synthesis mechanisms
- PARP inhibition in cancer therapy
- Natural Compound Pharmacology Studies
- TGF-β signaling in diseases
- CRISPR and Genetic Engineering
- Cancer, Stress, Anesthesia, and Immune Response
- Histone Deacetylase Inhibitors Research
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- Pregnancy and Medication Impact
West China Hospital of Sichuan University
2014-2024
Sichuan University
2014-2024
Scientific Methods (United States)
2023
The Nature Conservancy
2023
State Key Laboratory of Biotherapy
2008-2022
Hamilton Thorne (United States)
2021-2022
Shandong First Medical University
2021-2022
Shandong Tumor Hospital
2021-2022
Xuzhou Medical College
2015-2022
International Peace Maternity & Child Health Hospital
2022
Cancer is a complex disease resulting from abnormal cell growth that induced by number of genetic and environmental factors. The tumor microenvironment (TME), which involves extracellular matrix, cancer-associated fibroblasts (CAF), tumor-infiltrating immune cells angiogenesis, plays critical role in progression. Cyclic adenosine monophosphate (cAMP) second messenger has pleiotropic effects on the TME. downstream effectors cAMP include cAMP-dependent protein kinase (PKA), exchange activated...
Yeast cells, like mammalian enlarge steadily as they age. Unabated cell growth can promote cellular senescence; however, the significance of relationship between size and lifespan is not well understood. Herein, we report a genetic link size, rate lifespan. Mutations that increase concomitantly decrease As result, large cells grow, divide age dramatically faster than small cells. Conversely, mutants slowly are long-lived. Investigation mechanisms involved suggests attainment maximal...
Rationale: We found that a subset of signal transducer and activator transcription 3 (STAT3) translocated into mitochondria in phagocytes, including macrophages isolated from individuals with sepsis. However, the role mitochondrial STAT3 remains unclear. Method: To investigate function vivo, we generated inducible knock-in mice. A cytokine array analysis, CBA flow cytometry, immunofluorescence staining quantification metabolic analyses vivo were subsequently performed an LPS-induced sepsis...
Abstract Background Long-term high fat (HF) diet intake can cause neuroinflammation and cognitive decline through the gut-brain axis. (1, 3)/(1, 6)-β-glucan, an edible polysaccharide isolated from medical mushroom, Lentinula edodes ( L. ), has potential to remodel gut microbiota. However, effects of derived β-glucan against HF diet-induced remain unknown. This study aimed evaluate neuroprotective effect mechanism dietary L supplementation obesity-associated in mice fed by a diet. Methods...
Three new cytotoxic cyclopeptides belonging to iturin class have been isolated from marine bacterium Bacillus sp. These three compounds the activities. Their structures were determined based on chemical analysis and all kinds of spectroscopic techniques.
Abstract Introduction Aberrant microenvironment and endoplasmic reticulum (ER) stress are associated with solid-tumor progression. Stress proteins, like heat shock proteins glucose-regulated frequently overexpressed in human tumors. It has been reported that derlin-1 is involved ER response. In vitro studies have demonstrated participates the retrotranslocation of misfolded from into cytosol. Because roles cancer not yet characterized, we investigated expression breast carcinoma whether it...
Introduction: Clonorchis sinensis is one of the most important foodborne pathogens in humans, and can cause biliary diseases such as gallstones, cholecystitis, cholangitis, cholangiocarcinoma. Toll-like receptors (TLRs) sensors are crucial to initiating both innate adaptive immune defenses against pathogens. However, little known about hepatic expression TLRs hosts induced by C. infection. Methodology: In present study, distribution TLR2 TLR4 were investigated a mouse model clonorchiasis on...
Abstract Transforming growth factor β (TGF-β) is critical for embryonic development, adult tissue homeostasis, and tumor progression. TGF-β suppresses tumors at early stage, but promotes metastasis later stage through oncogenes such as Twist1. Gamma-synuclein (SNCG) overexpressed in a variety of invasive metastatic cancer. Here, we show that induces SNCG expression by Smad-Twist1 axis, thus promoting TGF-β- Twist1-induced cancer cell migration invasion. We identify multiple Twist1-binding...
Poly(ADP‑Ribose) polymerase family member 9 (PARP9) promotes the proliferation, survival and chemotherapy resistance in lymphoma prostate cancer. The expression function of PARP9 human breast cancer remains unknown. In present study, it was demonstrated that is frequently overexpressed 57 normal tissues, not detected 43 cases (75.4%), but low levels were 13 (22.8%), modest (PARP9/GAPDH ratio ~1:1) only 1 case (1.7%). contrast, all which higher than paired tissues. addition, high 43.8%...
To prevent genomic instability, cells respond to DNA lesions by blocking cell cycle progression and initiating repair. Homologous recombination repair of breaks requires CtIP-dependent resection the ends, which is thought play a key role in activation CHK1 kinase induce checkpoint. But mechanism still not fully understood. Here, we establish that And-1, replisome component, promotes DNA-end homologous recombination. Mechanistically, And-1 interacts with CtIP regulates recruitment damage...
Abstract Background Hepatocellular carcinoma (HCC) is one of the common cancers that are very aggressive. The secreted cytokine transforming growth factor-β (TGF-β) promotes cancer metastasis by multiple mechanisms such as epithelial-mesenchymal transition and immune evasion. canonical TGF-β signaling largely mediated smooth muscle actin/mothers against decapentaplegic (SMAD) proteins. current study aims to explore regulation TGF-β/SMAD selenophosphate synthetase 1 (SEPHS1). Methods...
Gamma synuclein (SNCG) is a neuronal protein that also aberrantly overexpressed in various types of human cancer. SNCG overexpression promotes cancer invasion and metastasis. However, the mechanisms drive metastasis upon expression remain elusive. Elucidation underlying promotion by may help discover therapeutic avenues for SNCG-overexpressed Here, we show transforming growth factor-β (TGF-β)-induced p38 mitogen-activated kinase (MAPK) phosphorylation. Mechanistically, p38MAPK...