A5100420495- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Urologic and reproductive health conditions
- Cardiac tumors and thrombi
- Tumors and Oncological Cases
- Bone Tumor Diagnosis and Treatments
- Vascular Tumors and Angiosarcomas
- Neurofibromatosis and Schwannoma Cases
- Cancer, Hypoxia, and Metabolism
- Lymphoma Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Adrenal and Paraganglionic Tumors
- Gastrointestinal Tumor Research and Treatment
- Breast Cancer Treatment Studies
- Lung Cancer Treatments and Mutations
- Neuroendocrine Tumor Research Advances
- Breast Lesions and Carcinomas
- Neuroblastoma Research and Treatments
- Neonatal Respiratory Health Research
- Cancer and Skin Lesions
- Respiratory Support and Mechanisms
- IgG4-Related and Inflammatory Diseases
- Cerebrovascular and Carotid Artery Diseases
- Ear and Head Tumors
- Soft tissue tumors and treatment
Sichuan University
2015-2025
West China Hospital of Sichuan University
2015-2025
Jinhua Academy of Agricultural Sciences
2024
Anhui Medical University
2023
Northern Jiangsu People's Hospital
2023
Yangzhou University
2023
Huanggang Central Hospital
2023
First Affiliated Hospital of Anhui Medical University
2023
Jinhua Central Hospital
2022
Wenzhou Medical University
2022
Objective The systemic spread of colorectal cancer (CRC) is dominated by the portal system and exhibits diverse patterns metastasis without systematical genomic investigation. Here, we evaluated evolution CRC with multiorgan metastases using multiregion sequencing. Design Whole-exome sequencing was performed on multiple regions (n=74) matched primary tumour, adjacent non-cancerous mucosa, liver lung from six patients CRC. Phylogenetic reconstruction evolutionary analyses were used to...
Ancillary molecular testing has been advocated for diagnostic accuracy in the differentiation of lipomas from atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDL); however, implications and specific indications use are not well-established current literature. Herein, we extend previous findings by quantitatively evaluating impact neoplasms our routine clinical practice, how it modifies historical perspective their course, effect distinct surgical procedures modulating risk...
Primary pleuropulmonary and mediastinal synovial sarcomas (PPMSSs) are extremely rare. The authors present the largest series in an Asian population. Between 2000 2015, 26 genetically confirmed PPMSSs were included. clinicopathologic features of all cases reviewed. Immunohistochemical staining was carried out using following antibodies: TLE1, cytokeratin (AE1/AE3), EMA, CD99, Bcl-2, CK7, CD34, S-100 protein, Ki-67. chromosomal translocation t(X;18)(p11.2;q11.2) detected by fluorescence situ...
Abstract Well‐differentiated liposarcoma (WDLS) is one of the most common malignant mesenchymal tumors and dedifferentiated (DDLS) a tumor consisting both WDLS transformed nonlipogenic sarcomatous component. Cytogenetically, characterized by presence ring or giant rod chromosomes containing several amplified genes, including MDM2 , TSPAN31, CDK4, others mainly derived from chromosome bands 12q13‐15. However, 12q13‐15 amplicon large discontinuous. The focus this study was to identify novel...
Low-grade osteosarcoma (LGOS) encompasses low-grade central (LGCOS) and parosteal (POS). LGOSs are characterized by a supernumerary ring giant rod chromosomes containing the 12q13-15 amplicon. The fibroblast growth factor receptor substrate 2 ( FRS2 ) gene is located close to MDM2 CDK4 . Recent studies identified consistent amplification of in atypical lipomatous tumor/well-differentiated liposarcoma dedifferentiated liposarcoma. aim this study was evaluate frequency its relationship with...
Epithelioid hemangioendothelioma (EHE) is a rare malignant vascular tumor. Most EHEs (>90%) cases harbor WWTR1::CAMTA1 fusion gene, and CAMTA1 immunohistochemistry (IHC) highly sensitive specific tool for EHE diagnosis. However, there exist CAMTA1-immunonegative cases, the majority of which YAP1::TFE3 fusion, with few having more fusions. Liver one most common sites EHE, where subtype dominates, other variants are extremely rare. Hence, we focused on hepatic to analyze clinicopathological...
Poly(ADP‑Ribose) polymerase family member 9 (PARP9) promotes the proliferation, survival and chemotherapy resistance in lymphoma prostate cancer. The expression function of PARP9 human breast cancer remains unknown. In present study, it was demonstrated that is frequently overexpressed 57 normal tissues, not detected 43 cases (75.4%), but low levels were 13 (22.8%), modest (PARP9/GAPDH ratio ~1:1) only 1 case (1.7%). contrast, all which higher than paired tissues. addition, high 43.8%...
Dermatofibrosarcoma protuberans (DFSP) is an uncommon cutaneous tumor in children. Most published articles are sporadic or small series and lack systematically molecular analyses. The aim of our study to better understand the clinicopathologic genetic features these rare lesions.All patients diagnosed with DFSP aged ≤ 18 years were retrospectively reviewed from January 2006 May 2022.A total 66 cases (32 male 34 female patients) identified, ages ranging 0.3 (median, 13 years). Tumor locations...
Latent metastasis of colorectal cancer (CRC) frequently develops months or years after primary surgery, followed by adjuvant therapies, and may progress rapidly even with targeted therapy administered, but the underlying mechanism remains unclear. Here, we aim to explore molecular basis for aggressive behavior latent in CRC. Transcriptional profiling pathway enrichment analysis paired metastatic tumor samples were performed. The mechanisms pleckstrin homology-like domain, family B, member 2...
Among those tumors with consistent USP6 rearrangement, some arise from soft tissue and show bone metaplasia, including myositis ossificans (MO), fibro-osseous pseudotumor of digits (FOPD), aneurysmal cyst (ST-ABC) fasciitis (FO). These lesions are easily confused malignancies because they a rapid growth rate brisk mitoses. Here, we aim to clarify the clinicopathologic genetic characteristics this entity analyze correlations among different subtypes in one largest cohorts.The features 73...
Background Myofibroblastic sarcoma was used to be a controversial neoplasm. This study investigated the clinicopathological features of 20 cases myofibroblastic arising in different locations. Methods The paraffin-embedded tissue samples from patients with were stained immunohistochemically, and 5 examined by electron microscopy. Student's t test analyze difference Ki-67 labeling index between grade 1 2 sarcomas. Results Histologically, tumors composed slender spindle cells eosinophilic...
Inflammatory myofibroblastic tumor (IMT) is a distinctive neoplasm that frequently arises in the lung and accounts for ~1% of tumors. Distant metastatic IMT extremely rare has been poorly investigated. This analysis was specifically performed to explore clinicopathological genetic features early distant IMT. Two typical patients with IMTs were selected, which accounted 1.13% all diagnosed last 5 years. One patient 55 year-old male, other 56 female. Both primary tumors arose from lung,...