A5032627999- interferon and immune responses
- Ocular Diseases and Behçet’s Syndrome
- Extracellular vesicles in disease
- Neurological Disease Mechanisms and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Brain Tumor Detection and Classification
- Heme Oxygenase-1 and Carbon Monoxide
- RNA Interference and Gene Delivery
- Microbial Natural Products and Biosynthesis
- Cardiovascular Disease and Adiposity
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced biosensing and bioanalysis techniques
- NF-κB Signaling Pathways
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Bioactive Compounds and Antitumor Agents
- Muscle activation and electromyography studies
- Retinal Diseases and Treatments
- Bone Metabolism and Diseases
- Dementia and Cognitive Impairment Research
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Carbohydrate Chemistry and Synthesis
East China University of Science and Technology
2025
Sichuan University
2025
West China Hospital of Sichuan University
2025
Changhai Hospital
2020-2024
Second Military Medical University
2020-2024
Guangdong Academy of Medical Sciences
2020
Guangdong Provincial People's Hospital
2020
Hebei Medical University
2014
Third Hospital of Hebei Medical University
2014
Diabetic retinopathy (DR) has characteristics of early loss capillary pericytes, contributing to aberrant endothelial proliferation and angiogenesis. The function extracellular vesicles (Evs) derived from mesenchymal stem cells (MSCs) in angiogenesis were investigated the present study. In particular, role microRNA-192 (miR-192) was described. Firstly, GSE60436 data set applied screen out that integrin subunit α1 (ITGA1) overexpressed DR. Subsequently, streptozotocin (STZ) used induce...
Diabetic retinopathy is one of the most characteristic complications diabetes mellitus, and pyroptosis plays acrucial role in onset development diabetic retinopathy. Although microRNA-192 (miR-192) has been demonstrated to be involved progression, best our knowledge, its potential mechanism cell have not studied. The present study that high glucose (HG) contributes retinal pigment epithelial (RPE) cells a dose-dependent manner. results revealed miR-192 was weakly expressed HG-induced RPE...
Background: Retinal pigment epithelial (RPE) cells have a pivotal function in preserving the equilibrium of retina and moderating immunological interaction between choroid retina. This study primarily focuses on delineating protective effect offered by Kaempferol (Kae) against RPE cell damage. Methods: Bioinformatics analysis was performed GSE30719 dataset to identify hub genes associated with RPE. Subsequently, we analyzed impact Kae apoptosis, viability, inflammatory response through...
Diabetic retinopathy (DR) is the main cause of vision loss in diabetic patients, which cannot be completely resolved by typical blood sugar control. Inflammation influences development DR, so reducing inflammatory response DR patients crucial to prevention DR. Therefore, we explored regulatory effect bone marrow mesenchymal stem cell (BMSC) exosomes on inflammation mice. In order analyze mechanism action, used BMSC exosomal miR-146a treat microglias mice observe cellular changes and...
The insulin receptor substrate 1 (IRS1) promotes bone formation via osteoblast proliferation mediated by PI3K/Akt signaling. A reduction in NFκB activity osteoblasts results an increase formation. signaling pathway leads to increased expression of BAX, which contributes apoptosis. purpose this study was investigate the recombinant plasmid enhanced green fluorescent protein-N1 (pEGFP-N1) that transferred IRS1 gene into vitro and evaluate effects overexpression on NFκBp65 BAX. Osteoblasts were...
We developed a novel nanostructure DNA probe for the in situ detection of ITGA1 and miR-192 retinoblastoma (RB) to study correlation between expression RB development. probes were carried by silica particles coated dioleoyl-trimethy-lammonium-propane, which enhances their organizational compatibility infiltration capacity. This has stable physicochemical properties high specificity sensitivity detect both cell lines tissues. Using tissue lines, we found that ITAG1 drastically increased, but...
Objective To investigate the relationship between educational level and cognitive function in patients with non-dementia Parkinson′s disease (PD). Methods Forty PD forty healthy controls (HC) enrolled Beijing Hospital from January to December 2018 were collected for study. The two groups divided into three subgroups (low, medium high) according their years of education. HC group matched age, gender, education, Mini-Mental State Examination score. All subjects underwent tests executive...