A5013466894- Parkinson's Disease Mechanisms and Treatments
- Restless Legs Syndrome Research
- SARS-CoV-2 and COVID-19 Research
- Sleep and Wakefulness Research
- Neuroscience and Music Perception
- COVID-19 Clinical Research Studies
- Neurological Disease Mechanisms and Treatments
- Neurological and metabolic disorders
- Epilepsy research and treatment
- Diverse Music Education Insights
- Alzheimer's disease research and treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Brain Tumor Detection and Classification
- Ginkgo biloba and Cashew Applications
- Music Therapy and Health
- Diverse Scientific Research Studies
- Transgenic Plants and Applications
- Hallucinations in medical conditions
- Parkinson's Disease and Spinal Disorders
- Dementia and Cognitive Impairment Research
- Nuclear Receptors and Signaling
- Hearing Loss and Rehabilitation
- Cerebrospinal fluid and hydrocephalus
- RNA Research and Splicing
- Pharmacy and Medical Practices
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2023
Beijing Hospital
2015-2022
Sinovac Biotech
2020
Vaccine candidate tested in monkeys Global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an urgent race develop a vaccine. Gao et al. report preclinical results early vaccine called PiCoVacc, which protected rhesus macaque against SARS-CoV-2 infection when analyzed short-term studies. The researchers obtained multiple strains from 11 hospitalized patients across the world and then chemically inactivated harmful properties virus. Animals were immunized with...
Abstract The COVID-19 pandemic caused by SARS-CoV-2 has brought about an unprecedented crisis, taking a heavy toll on human health, lives as well the global economy. There are no SARS-CoV-2-specific treatments or vaccines available due to novelty of this virus. Hence, rapid development effective against is urgently needed. Here we developed pilot-scale production purified inactivated virus vaccine candidate (PiCoVacc), which induced neutralizing antibodies in mice, rats and non-human...
Many SARS-CoV-2 neutralizing antibodies (nAbs) lose potency against variants of concern. In this study, we developed 2 strategies to produce mutation-resistant antibodies. First, a yeast library expressing mutant receptor binding domains (RBDs) the spike protein was utilized screen for potent nAbs that are least susceptible viral escape. Among candidate antibodies, P5-22 displayed ultrahigh virus neutralization as well an outstanding mutation resistance profile. Additionally, P14-44 and...
Background: Individuals with Parkinson disease (PD) display cognitive dysfunction. However, few studies have investigated how facial and musical emotion recognition are affected in individuals PD. Objective: To explore the relationship between executive functions Chinese Methods: We showed 40 PD healthy controls 24 black-and-white portraits excerpts that were designed to express happiness, sadness, fear, anger. Then, we used four tests assess participants’ functions, including Trail Making...
<b><i>Objectives:</i></b> Studies documenting the association between rapid eye movement sleep behavior disorder (RBD) and subtypes of multiple system atrophy (MSA) are rare. In this study, we investigated presence clinical RBD in MSA patients compared prevalence severity with MSA-P MSA-C subtypes. <b><i>Methods:</i></b> We evaluated 54 consecutive presenting hospitalized neurology ward Beijing Hospital from February 2012 to June 2020. The...
To investigate the prevalence and influencing factors of visual hallucinations in patients with Parkinson's disease(PD), to analyze relationship between sleep disorders.We recruited 187 PD(H-Y Ⅰ-Ⅲ) from outpatient department Beijing Hospital. The were investigated for general information use medicine. divided into hallucination(VH) group non-hallucination(non-VH) group. A comparison study was conducted two groups. We disorders PD according Non Motor Symptom Quest(NMSquest) disease...
Abstract Background Heart failure is a complex syndrome that hinders the heart's ability to provide oxygen tissues and significant cause of death globally. Given left ventricular more common than atrial failure, this study utilizes single-cell RNA-sequencing data detect differentially expressed genes (DEGs) between endothelial cells two chambers examines whether these DEGs are related heart development. Method The analysis healthy human dataset was performed using Seurat, an R package,...
Objective To investigate emotion recognition in music patients with idiopathic Parkinson's disease (PD), and to further explore its relationship executive function related factors. Methods Twenty-four PD enrolled from the Department of Neurology, Beijing Hospital between January June 2014 24 matched healthy controls were tested using musical excerpts that expressed happiness, sadness, fear or anger. The two groups for a simplified trail making test clock drawing test. All rated on...
Objective To investigate the incidence and severity of clinical rapid eye movement sleep behavior disorder (RBD) in Parkinson′s disease (PD), association with motor subtypes. Methods We recruited 187 patients PD(Hoehn-Yahr stageⅠ-Ⅲ) from outpatient department Beijing Hospital. The general information was collected Unified Disease Rating Scale (UPDRS) scores were caculated. divided into two subgroups as tremor dominant (TD) non-tremor (NTD). One hundred matched healthy controls (HC)...
Introduction: Sleep disorders are common in Parkinson’s disease (PD) and significantly impact quality of life. Herein, we surveyed the incidence severity sleep Chinese PD patients observed their relationship with dopaminergic drugs. Methods: We collected demographic information 232 patients. The were scale (PDSS) version. Data on drug intake converted to levodopa equivalent doses (LED). Results: average total score PDSS was 119.3 ± 19.7. There a significant difference scores between groups...
Objective To design the APP of oral medication dedicated voice prompts for patients in department neurology and investigate effects on adherence their self-management efficiency. Methods Common medicine was divided into 10 categories. Thirty species from each category which required special were selected. According to time, method, precautions adverse drug reactions, normative designed. Audio files recorded using computer recording software made a APP. Two hundred hospitalized...
Objective To survey the prevalence and distribution of sleep disorders in patients with Parkinson disease (PD) to analyze influencing factors. Methods The were surveyed Disease Sleep Scale (PDSS) among 206 PD patients. The association age, course disease, cognitive function, motor depression, equivalent dose levodopa (LED) was analyzed. Results The overall PDSS score (116.9±21.4). three most frequent items quality(181/206, 87.9%), difficulty maintaining sleep(160/206, 77.7%)and...
Objective To investigate the relationship between educational level and cognitive function in patients with non-dementia Parkinson′s disease (PD). Methods Forty PD forty healthy controls (HC) enrolled Beijing Hospital from January to December 2018 were collected for study. The two groups divided into three subgroups (low, medium high) according their years of education. HC group matched age, gender, education, Mini-Mental State Examination score. All subjects underwent tests executive...
原发性帕金森病是一种隐匿起病、缓慢进展的神经变性病。结合基层医疗的特点和需求，首次制订了我国《帕金森病基层诊疗指南（2019年）》。本文特别对指南中的诊断步骤、治疗及基层管理等作出说明，便于基层医生理解和更方便地应用该指南。
Abstract Background: People with arteriosclerotic cardiovascular diseases (ASCVD) frequently use antithrombotic agents and statins. The objective of the study was to explore prevalence risk factors cerebral microbleeds (CMB) in elderly Chinese people ASCVD. Methods: We prospectively continuously enrolled 755 participants (≥ 65 years old) Beijing hospital’s health checkup center from February 1, 2019 June 30, 2021. MRI protocol imaging analysis were implemented identify CMB, multivariate...