A5100438782- Neurological Disease Mechanisms and Treatments
- Molecular Sensors and Ion Detection
- Cancer-related molecular mechanisms research
- Sulfur Compounds in Biology
- Barrier Structure and Function Studies
- Redox biology and oxidative stress
- Growth Hormone and Insulin-like Growth Factors
- Drug-Induced Hepatotoxicity and Protection
- Cholinesterase and Neurodegenerative Diseases
- Advanced Computing and Algorithms
- Obesity, Physical Activity, Diet
- Regulation of Appetite and Obesity
- Cancer Treatment and Pharmacology
- Phytochemical compounds biological activities
- Biological Activity of Diterpenoids and Biflavonoids
- Alzheimer's disease research and treatments
- Epigenetics and DNA Methylation
- Liver physiology and pathology
- Folate and B Vitamins Research
- Nerve injury and regeneration
- Metabolism and Genetic Disorders
- 14-3-3 protein interactions
- Biological and pharmacological studies of plants
- Axon Guidance and Neuronal Signaling
- Drug Transport and Resistance Mechanisms
Qiqihar Medical University
2012-2025
Shanghai University of Medicine and Health Sciences
2018
Union Hospital
2010
Huazhong University of Science and Technology
2010
Introduction Glyphosate (GLP) is one of the most widely used herbicides in world. However, its underlying effects on liver remain unclear. This study aims to investigate toxic and gut microbiome– serum metabolite–related mechanisms GLP mice. Methods 16S rDNA sequencing UPLC-Q-TOF-MS/MS were toxicity mice administered with 0, 50, 250 500 mg/kg/day for 30 days. Results induced hepatocyte edema ballooning as well inflammatory cell infiltration. Exposure resulted increased levels ALT, TBIL,...
Colorectal cancer (CRC) affects people globally, and lymph node metastasis (LNM) is an important indicator of poor clinical outcome in CRC. The current study aims to evaluate the role microRNA-448 (miR-488) claudin-2 (CLDN2) epithelial-mesenchymal transition (EMT) LNM CRC through MAPK signaling pathway. First, microarray analysis indicated that miR-488 was poorly expressed CRC, whereas CLDN2 highly expressed. Additionally, bioinformatics website MicroRNA.org dual luciferase reporter gene...
Owing to the important physiological sits of biothiols (Cys, Hcy, and GSH), developing accurate detection methods capable qualitative quantitative analysis in living systems is needed for understanding biological profile biothiols. In this work, we have designed synthesized a 4'-hydroxy-[1,1'-biphenyl]-4-carbonitrile modified with NBD group-based fluorescent probe, BPN-NBD, sensitive Cys/Hcy GSH by dual emission signals via single-wavelength excitation. BPN
The well-known small-molecule biothiols have been used to maintain the normal metabolism of peroxy radicals, forming protein structures, resisting cell apoptosis, regulating metabolism, and protecting homeostasis cells in organism. A large amount research has found that abnormal levels above can cause some adverse diseases, such as changes hair pigmentation, a slower growth rate, delayed response, excessive sleep skin diseases. In order further investigate exact intracellular molecular...
This study aimed to explore the expression level of miR-539 in blood-brain barrier permeability induced by cerebrovascular occlusion and its mediated mechanism. Altogether, 48 patients with cerebral vascular lesions from March 2018 June 2020 were collected. The peripheral blood serum subjects was analyzed qRT-PCR, participants divided into two groups according results head neck ultrasound CTA hemodynamics. MCAO model ischemia established rats, detected qRT-PCR brain tissues different rats....
The antitumor activities of natural paclitaxel (PTX), semisynthetic docetaxel, and cabazitaxel are highly dependent on their C-13 side chains. Therefore, using ergosterol peroxide (EP, 1) as the lead compound, two EP-PTX hybrids (EP-A2 EP-B2) were prepared evaluated against 4 kinds human MCF-7, HepG2, HCT-116, A549 cell lines in vitro. results showed that both EP-A2 EP-B2 inhibited growth all four tested tumor lines. For paclitaxel-resistant MCF-7 cells, significant inhibitory activity with...
Objective To study the effect of electroacupuncture (EA) combined with transcranial magnetic stimulation (TMS) on expression B-cell lymphoma/leukemia-2 gene (Bcl-2) and brain derived neurotrophic factor (BDNF) after cerebral infarction. Methods One hundred Sprague-Dawley rats were randomly equally divided into a normal group, sham-operated control model group an EA plus TMS group. A infarction was established in latter two groups using left middle artery occlusion (MCAO). Five-member...
Objective To study the effect of transcranial magnetic stimulation （TMS） on rehabilitation rats with cerebral infarction. Methods One hundred Sprague-Dawley were randomly divided into a normal group, sham-operated control model group and TMS 25 in each group. A infarc- tion was established latter two groups by left middle artery occlusion （MCAO）. started at either 12 or 24 hours after reperfusion, sham-TMS given to first same time points. The expression Bcl-2 mRNA BDNF measured RT-PCR 14...
Objective To observe the changes of sodium iodide symporter (NIS) in mammary gland rats at different lactation periods, and to explore iodine uptake mechanism. Methods Seventy-five adult Wistar were selected, including 60 females, 15 males, weighting 220-250 g. All female divided into 4 groups according their body mass via random number table method: normal non-pregnant group, lactating for 7-, 14- 21- day groups, each group. fed with adequate conventional fodder tap water. In...
Objective To investigate the relationship between educational level and cognitive function in patients with non-dementia Parkinson′s disease (PD). Methods Forty PD forty healthy controls (HC) enrolled Beijing Hospital from January to December 2018 were collected for study. The two groups divided into three subgroups (low, medium high) according their years of education. HC group matched age, gender, education, Mini-Mental State Examination score. All subjects underwent tests executive...
A series of novel ergosterol peroxide derivatives with acrylate or propionate side chain were synthesized. All compounds 3a-n evaluated for their cytotoxicity against four kinds human carcinoma cell lines (HepG2, MCF-7, HCT-116, and A549). Most the displayed stronger than parent. Among them, compound 3h highest potency HepG2 line (IC 50 = 2.70 μM), which was 7.47-fold more efficacious peroxide. The results suggested that introduction at C-3 position is beneficial to enhance its cytotoxic...