A5114321310- Renal Diseases and Glomerulopathies
- COVID-19 epidemiological studies
- Complex Systems and Time Series Analysis
- Chronic Kidney Disease and Diabetes
- Neurological Disease Mechanisms and Treatments
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Traditional Chinese Medicine Analysis
- Mathematical and Theoretical Epidemiology and Ecology Models
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- Liver physiology and pathology
- Cardiovascular Disease and Adiposity
- Fungal Biology and Applications
- Drug-Induced Hepatotoxicity and Protection
- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Polysaccharides and Plant Cell Walls
- COVID-19 Clinical Research Studies
- Pancreatic and Hepatic Oncology Research
- Adrenal Hormones and Disorders
- Medication Adherence and Compliance
- Women's cancer prevention and management
- Natural Compounds in Disease Treatment
- Potassium and Related Disorders
Shandong First Medical University
2025
Shandong University
2025
Shandong Provincial Hospital
2025
Zhujiang Hospital
2022-2024
Southern Medical University
2020-2024
Beijing University of Chinese Medicine
2020-2024
Capital Medical University
2022-2024
Nanjing Drum Tower Hospital
2024
Vanderbilt University
2024
Beijing Friendship Hospital
2022-2024
Abstract The COVID-19 pandemic caused by SARS-CoV-2 has brought about an unprecedented crisis, taking a heavy toll on human health, lives as well the global economy. There are no SARS-CoV-2-specific treatments or vaccines available due to novelty of this virus. Hence, rapid development effective against is urgently needed. Here we developed pilot-scale production purified inactivated virus vaccine candidate (PiCoVacc), which induced neutralizing antibodies in mice, rats and non-human...
Abstract Clonal hematopoiesis (CH) can be caused by either single gene mutations (eg point in JAK2 causing CHIP) or mosaic chromosomal alterations (e.g., loss of heterozygosity at chromosome 9p). CH is associated with a significantly increased risk hematologic malignancies. However, the absolute rate transformation on an annualized basis low. Improved prognostication urgently needed for routine clinical practice. We hypothesized that co-occurrence CHIP and mCAs same locus transforming...
Atherosclerosis and aortic aneurysms are prevalent cardiovascular diseases in the elderly, characterized by chronic inflammation oxidative stress. This study explores role of CircXYLT1 regulating stress vascular remodeling age-related diseases. RNA sequencing revealed a significant upregulation tissues aged mice, highlighting its potential Using carotid artery wire injury model, we performed adeno-associated virus (AAV)-mediated knockdown overexpression CircXYLT1. Key markers, including...
Aim Aortic aneurysm is characterized by localized expansion and damage to the vessel wall. While apolipoprotein B (ApoB) has been linked atherosclerosis, its causal relationship with aortic remains unclear. This study used a Mendelian randomization (MR) approach explore relationships between ApoB, aneurysm, potential mediators. Material methods Single nucleotide polymorphism (SNP) data related A1 (ApoA1), triglycerides, frailty index, were obtained from large-scale genome-wide association...
Abstract Background Autotetraploid rice is a useful germplasm for polyploid breeding. Our previous research showed that non-coding RNAs might be associated with low fertility in autotetraploid rice. However, little information available on long (lncRNAs) involved the of In present study, RNA-seq was employed to detect differentially expressed meiosis-related lncRNAs rice, and gene overexpression knock out experiments were used validate potential function candidate lncRNA. Results A total 444...
Electronic health records (EHR) are increasingly used for studying multimorbidities. However, concerns about accuracy, completeness, and EHRs being primarily designed billing administrative purposes raise questions the consistency reproducibility of EHR-based multimorbidity research.
Diurnal floret opening time (DFOT) is a pivotal trait for successful fertilization and hybrid breeding in rice. However, the molecular mechanism underlying this poorly understood In study, we combined cytological, genetic studies to demonstrate that jasmonic acid (JA) regulates DFOT rice through modulating turgor osmotic pressure of lodicules. We show lodicules undergo dramatic morphologic changes, accompanied by changes water sugar contents during process opening. Consistently, large set...
The spatial diffusion of epidemic disease follows distance decay law in geography and social physics, but the mathematical models depend on concrete spatio-temporal conditions. This paper is devoted to modeling patterns COVID-19 stemming from Wuhan city Hubei province, China. approach integrate analytical method experimental method. local gravity model derived allometric scaling global model, then parameters are estimated by observational data least squares calculation. main results as...
Hepatic fibrosis has been widely considered as a conjoint consequence of almost all chronic liver diseases. Chuanxiong Rhizoma (Chuanxiong in Chinese, CX) is traditional Chinese herbal product to prevent cerebrovascular, gynecologic and hepatic Our previous study found that CX extracts significantly reduced collagen contraction force stellate cells (HSCs). Here, this aimed compare the protection different on bile duct ligation (BDL)-induced investigate plausible underlying mechanisms. The...
In order to study the asymmetric multifractality in maritime shipping freight rates, we have resorted use of novel approach Multifractality Detrended Fluctuation Analysis. This examines response towards downward and upward movements. The outcomes this regard show that major rates multifractals, which tend increase as fractal scale also increases. Also, a higher level is observed movements for Baltic Dry Index, Clean Tanker suggesting both indexes been less efficient, unpredictable during...
Objective Flares of lupus nephritis (LN) are frequent and associated with impaired renal prognosis. One major management obstacle in LN flare is the lack effective methods to identify at‐risk patients earlier their disease course. This study was undertaken test utility measurement urinary matrix metalloproteinase 7 (MMP‐7) for dynamic surveillance activity prediction flares LN. Methods A prospective, 2‐stage cohort performed Urinary MMP‐7 levels at time biopsy were evaluated 154 newly...
Donafenib (DONA), a deuterium derivative of sorafenib, is used for advanced hepatocellular carcinoma (HCC). Dapagliflozin (DAPA) and canagliflozin (CANA) are sodium-glucose co-transporter 2 (SGLT2) inhibitors T2DM, which frequently comorbid with HCC. Three drugs substrates UGT1A9 isoenzyme. This study aimed to evaluate donafenib-dapagliflozin donafenib-canagliflozin pharmacokinetic interactions explore the potential mechanisms. Rats were divided into seven groups (n = 6) that received...
The increasing incidence of diseases caused by Coxsackievirus A6 (CV-A6) and the presence various mutants in population present significant public health challenges. Given concurrent development multiple vaccines China, it is challenging to objectively accurately evaluate level neutralizing antibody response different vaccines. choice detection strain a crucial factor that influences antibodies. In this study, National Institutes for Food Drug Control collected prototype (Gdula), one...
Acute kidney injury (AKI) represents a diverse range of conditions characterized by high incidence and mortality rates, it is mainly associated with immune-mediated mechanisms mitochondrial metabolism dysfunction. Cuproptosis, recently identified form programmed cell death dependent on copper, closely linked to respiration contributes various diseases. Our study aimed investigate the involvement cuproptosis-related genes (CRGs) in AKI.
Abstract Background IgA nephropathy (IgAN), which has been reported as the most prevalent glomerulonephritis globally, is major contributor to end-stage renal diseases. This bioinformatics study aimed explore glomerulotubular crosstalk genes and dysregulated pathways relating pathogenesis of IgAN. Methods The microarray datasets from Gene Expression Omnibus (GEO) database were searched. Weighted gene co-expression network analysis (WGCNA) differentially expressed (DEGs) both glomeruli...
Diabetic encephalopathy (DE) is a complication of diabetes that leads to cognitive and behavioral decline. Utilizing safe effective complementary alternative medications for its management wise choice. Previous studies have shown GuanXinNing Tablet (GXNT), an oral preparation primarily derived from two Chinese herbs, Salvia miltiorrhiza Bge. Ligusticum chuanxiong Hort., exerts beneficial neuroprotective effect. In this study, we explored the protective effects GXNT on DE in male Zucker...