A5073383860- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Liver physiology and pathology
- Pharmacological Effects of Natural Compounds
- Liver Diseases and Immunity
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease and Transplantation
- Natural product bioactivities and synthesis
- Sphingolipid Metabolism and Signaling
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Phytochemistry and Biological Activities
- Lipid metabolism and disorders
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Natural Compounds in Disease Treatment
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Phytochemistry and biological activity of medicinal plants
- MicroRNA in disease regulation
- Cytokine Signaling Pathways and Interactions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammasome and immune disorders
- Gut microbiota and health
Beijing University of Chinese Medicine
2019-2025
Virginia Commonwealth University
2017-2020
Hunter Holmes McGuire VA Medical Center
2017-2020
Second Hospital of Shandong University
2019
Virginia Commonwealth University Medical Center
2017-2019
Shandong University
2018
China Pharmaceutical University
2014-2017
Inova Fairfax Hospital
2017
Activation of hepatic stellate cells (HSCs) represents the primary driving force to promote progression chronic cholestatic liver diseases. We previously reported that cholangiocyte-derived exosomal long noncoding RNA-H19 (lncRNA-H19) plays a critical role in promoting injury. However, it remains unclear whether lncRNA-H19 regulates HSC activation, which is major focus this study. Both bile duct ligation (BDL) and Mdr2 knockout (Mdr2-/- ) mouse models were used. Wild-type H19maternalΔExon1/+...
Bile duct obstruction is a potent stimulus for cholangiocyte proliferation, especially large cholangiocytes. Our previous studies reported that conjugated bile acids (CBAs) activate the protein kinase B (AKT) and extracellular signal-regulated 1 2 (ERK1/2) signaling pathways through sphingosine 1-phosphate receptor (S1PR) in hepatocytes cholangiocarcinoma cells. It also has been taurocholate (TCA) promotes proliferation protects cholangiocytes from ligation (BDL)-induced apoptosis. However,...
Cholestatic liver injury is an important clinical problem with limited understanding of disease pathologies. Exosomes are small extracellular vesicles released by a variety cells, including cholangiocytes. Exosome‐mediated cell‐cell communication can modulate various cellular functions transferring intracellular components to target cells. Our recent studies indicate that the long noncoding RNA (lncRNA), H19, mainly expressed in cholangiocytes, and its aberrant expression associated...
Biliary atresia (BA) is a neonatal liver disease featuring cholestasis and severe fibrosis (LF). Despite advances in the development of surgical treatment, lacking an early diagnostic marker intervention LF invariably leads to death from end-stage years life. We previously reported that knockout sphingosine 1-phosphate receptor 2 (S1PR2) protected mice bile duct ligation (BDL)-induced cholangiocyte proliferation LF. Our recent studies further showed both hepatic serum exosomal long noncoding...
The multidrug resistance 2 knockout (Mdr2-/- ) mouse is a well-established model of cholestatic cholangiopathies. Female Mdr2-/- mice develop more severe hepatobiliary damage than male mice, which correlated with higher proportion taurocholate in the bile. Although estrogen has been identified as an important player intrahepatic cholestasis, underlying molecular mechanisms gender-based disparity injury remain unclear. long noncoding RNA H19 imprinted, maternally expressed, and...
Cirrhosis and hepatic encephalopathy (HE) is associated with an altered gut-liver-brain axis. Fecal microbial transplant (FMT) after antibiotics improves outcomes in HE, but the impact on brain function unclear. The aim of this study to determine effect colonization using human donors germ-free (GF) mice GF conventional were made cirrhotic carbon tetrachloride compared controls state. Additional colonized stool from (Ctrl-Hum) patients cirrhosis (Cirr-Hum). Stools HE pooled (pre-FMT). same...
Activation of hepatic macrophages represents the critical driving force to promote cholestatic liver injury. Exosomes, as important small extracellular vesicles released by almost all types cells, contribute intercellular communication. We previously reported that cholangiocyte-derived exosomal long noncoding RNA (lncRNA) H19 plays a vital role in disrupting bile acid homeostasis hepatocytes and promoting activation stellate cells (HSCs). Exosomal derived from cholangiocytes was rapidly...
Inflammation plays an essential role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Berberine (BBR), isoquinoline alkaloid isolated from Chinese medicinal herbs, has been widely used to treat various diseases, including diseases for hundreds years. The previous studies have shown that BBR inhibits high fat-diet-induced steatosis and inflammation rodent models NAFLD. However, underlying molecular mechanisms remain unclear. This study is aimed identify potential by which...
Nonalcoholic fatty liver disease (NAFLD) has become one of the most prominent causes chronic diseases and malignancies. However, few therapy been approved. Radix Bupleuri (RB) is frequently used herbal medicine for treatment diseases. In current study, we aim to systemically evaluate therapeutic effects saikosaponin A (SSa) D (SSd), major bioactive monomers in RB, against NAFLD investigate underlying mechanisms. Our results demonstrated that both SSa SSd improved diet-induced NAFLD....
Cholangiocarcinoma (CCA) is a rare, but highly malignant primary hepatobiliary cancer with very poor prognosis and limited treatment options. Our recent studies reported that conjugated bile acids (CBAs) promote the invasive growth of CCA via activation sphingosine 1-phosphate receptor 2 (S1PR2). Cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) most abundant in various human malignancies including CCA. Previous have indicated COX-2 was expressed tissues, survival rate patients...
Chronic inflammation in response to persistent exogenous stimuli or damage results liver fibrosis, which subsequently progresses into malignant diseases with high morbidity and mortality. Ferulic acid (FA) is a phenolic widely isolated from abundant plants exhibits multiple biological activities including anti-oxidant, anti-inflammation enhancement of immune responses. Adenosine monophosphate-activated protein kinase (AMPK) functions as critical energy sensor regulated through the...
Nonalcoholic fatty liver disease (NAFLD), manifested as the aberrant accumulation of lipids in hepatocytes and inflammation, has become an important cause advanced diseases hepatic malignancies worldwide. However, no effective therapy been approved yet. Aurantio-obtusin (AO) is a main bioactive compound isolated from Cassia semen that identified with multiple pharmacological activities, including improving adiposity insulin resistance. ameliorating effects AO on diet-induced NAFLD underlying...
Impaired intestinal barrier function promotes the progression of various liver diseases, including cholestatic diseases. The close association primary sclerosing cholangitis (PSC) with inflammatory bowel disease highlights importance gut‐liver axis. It has been reported that bile duct ligation (BDL)‐induced fibrosis is significantly reduced in C/EBP homologous protein knockout (CHOP −/− ) mice. However, underlying mechanisms remain unclear. In current study, we demonstrate BDL induces...