A5051094170- Ovarian function and disorders
- Hormonal Regulation and Hypertension
- Reproductive Biology and Fertility
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Diabetes Management and Research
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Growth Hormone and Insulin-like Growth Factors
- Traditional Chinese Medicine Studies
- Chronic Kidney Disease and Diabetes
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Cancer, Hypoxia, and Metabolism
- Renal Diseases and Glomerulopathies
- Birth, Development, and Health
- Thyroid Disorders and Treatments
- Peroxisome Proliferator-Activated Receptors
- Pituitary Gland Disorders and Treatments
Nanjing Drum Tower Hospital
2016-2025
National Clinical Research Center for Digestive Diseases
2024-2025
Nanjing University of Chinese Medicine
2020-2024
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2022
Hong Kong Polytechnic University
2022
Jiaxing University
2022
Nanjing University
2010-2022
China Pharmaceutical University
2022
National Clinical Research
2022
Christie's
2021
The aim of the present study was to compare effects gliclazide, liraglutide, and metformin in type 2 diabetes mellitus (T2DM) patients with non-alcoholic fatty liver disease (NAFLD).Eighty-seven subjects were randomized receive metformin, or gliclazide for 24 weeks. Primary outcomes included HbA1c levels, intrahepatic fat (IHF) content, function.Both levels IHF content reduced after treatment all three groups. However, lower liraglutide- metformin-treated groups than gliclazide-treated...
This study aimed to investigate the effect of polycystic ovary syndrome (PCOS) on association aromatase activity assessed by estradiol-to-testosterone ratio (E2/T) with body mass index (BMI) in women.This was a cohort five centers for reproductive medicine China. Data were collected from July 2012 December 2013. PCOS patients (n = 785) and non PCOS, healthy, age-matched controls 297) included. Plasma sex hormones including estradiol (E2), testosterone (T), follicle stimulating hormone (FSH),...
To compare the effects of gliclazide, liraglutide and metformin on body composition in patients with type 2 diabetes mellitus non-alcoholic fatty liver disease.A total 85 were randomly allocated to receive gliclazide (n = 27), 29) or monotherapy for 24 weeks. Body was measured using dual-energy X-ray absorptiometry.Liraglutide reduced total, trunk, limb, android gynoid fat mass; this also led weight reduction. However, treatment produced no significant changes mass, likely because reductions...
Autologous hematopoietic stem cell transplantation (AHSCT) has the potential to induce clinical remission in patients with newly diagnosed type 1 diabetes.The objective of study was examine impact AHSCT on lymphocytes and pancreatic β-cell function.This a nonrandomized, open-label prospective study.Thirteen new onset diabetes, 10 them diabetic ketoacidosis, were subjected cryopreserved CD34(+) progenitor cells followed up for 31-54 months.The numbers different subsets levels serum cytokines,...
The polycystic ovary syndrome (PCOS) is a common metabolic and endocrine disorder with pathological mechanisms remain unclear. following study investigates the ovarian hyperfibrosis forming via transforming growth factor-β (TGF-β) signaling pathway in Dehydroepiandrosterone (DHEA)- induced rat model. We furthermore explored whether TGF-βRI inhibitor (SB431542) decreases fibrosis by counterbalancing expression of fibrotic biomarkers.Thirty female Sprague-Dawley rats were randomly divided into...
Rats with hyperandrogen-induced polycystic ovary syndrome (PCOS) have been shown to develop ovarian oxidative stress (OS) and fibrosis. The Sirt1 agonist, resveratrol, can reduce OS through inhibiting p66Shc in other models of OS.We created a rat PCOS model increased levels following treatment one the two androgens, dehydroepiandrosterone (DHEA) dihydrotestosterone (DHT). related features were determined by measurement malondialdehyde (MDA) superoxide dismutase (SOD) or examining reactive...
Abstract Background The preservation or restoration of β cell function in type 1 diabetes (T1D) remains as an attractive and challengeable therapeutic target. Mesenchymal stromal cells (MSCs) are multipotent with high capacity immunoregulation, which emerged a promising cell-based therapy for many immune disorders. objective this study was to examine the efficacy safety one repeated transplantation allogeneic MSCs individuals T1D. Methods This nonrandomized, open-label, parallel-armed...
Excessive production of androgen drives oxidative stress (OS) and inflammasome activation in ovarian granulosa cells (GCs). Therefore, the induced follicular developmental disorder is major cause infertility women with polycystic ovary syndrome (PCOS). Exercise-induced upregulation irisin capable regulating metabolism by reducing OS inflammation. Exercise has been shown to alleviate a range PCOS symptoms, including maintaining normal menstrual cycle, several clinical trials.Female...
Silymarin is a potent antioxidant medicine and has been widely used for the treatment of liver diseases over 30 years. Recent studies suggest that silymarin may benefit patients with glucose intolerance. However, mechanism underlying action not clarified. The aim this work was to assess impact on intolerance in high-fat diet (HFD)-fed mice, explore potential therapeutic mechanisms. C57BL/6 mice were fed HFD 12 weeks, randomized, treated orally vehicle saline or (30 mg/kg) daily days. We...
Women with polycystic ovary syndrome (PCOS) show high prevalence of glucose intolerance. This study aimed to investigate the association androgen excess intolerance in PCOS. A total 378 women PCOS participated study. Free index (FAI) was selected as indicator hyperandrogenism. Insulin sensitivity assessed by 1/homeostasis model assessment insulin resistance (1/HOMA-IR) and Matsuda (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mi...
Recent studies have shown placenta-derived exosome (pdE) acts as an important mediator of organ-to-organ interplay regulating maternal metabolic alterations, however, the function and mechanisms placental exosomes on pancreatic β-cell maladaptation in gestational diabetes mellitus (GDM) remain unclear. The purpose this investigation was to ascertain how affected dysfunction associated with onset GDM. Exosomes were isolated from chorionic villi explants pregnant mice humans normal glucose...
This study aimed to investigate the effect of mid-pregnancy lipid levels on adverse outcomes in women with gestational diabetes mellitus (GDM) under adequate glycemic control. Whether this is independent factors such as blood glucose was also analyzed. We retrospectively analyzed 1,001 normal tolerance (NGT) and 1,078 GDM control from 2015 2024. Logistic regression analysis used explore relationship between lipids outcomes. Those were further classified according their pre-pregnancy body...
Multi-glycoside of Tripterygium wilfordii Hook. f. (GTW) has been proven to be clinically effective in relieving microinflammation patients with early diabetic nephropathy (DN). However, the therapeutic mechanisms involved vivo remain unclear. In process DN, and activation p38 mitogen‑activated protein kinase (MAPK) canonical nuclear factor (NF)-κB signaling pathways are important by which hyperglycemia contributes glomerulosclerosis (GS). Therefore, this study aimed examine ameliorative...