A5101701650- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory Support and Mechanisms
- Infant Nutrition and Health
- Gut microbiota and health
- Diet and metabolism studies
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Digestive system and related health
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Studies on Chitinases and Chitosanases
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Cancer, Hypoxia, and Metabolism
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Studies
- Sirtuins and Resveratrol in Medicine
- Tea Polyphenols and Effects
- Nosocomial Infections in ICU
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gastroesophageal reflux and treatments
- Sarcoidosis and Beryllium Toxicity Research
Sichuan University
2024-2025
Nanjing Drum Tower Hospital
2025
Nanjing University
2013-2025
University of California, Davis
2012-2025
West China Hospital of Sichuan University
2024
Capital Medical University
2013-2024
Hospital de Santo Espirito de Angra do Heroísmo
2024
University of Toronto
2016-2024
McMaster University
2024
St. Michael's Hospital
2024
Abstract Human milk delivers an array of bioactive components that safeguard infant growth and development maintain healthy gut microbiota. Milk fat globule membrane (MFGM) is a biologically functional fraction increasingly linked to beneficial outcomes in infants through protection from pathogens, modulation the immune system improved neurodevelopment. In present study, we characterized fecal microbiome metabolome fed bovine MFGM supplemented experimental formula (EF) compared standard (SF)...
Type 2 diabetes is characterized by dyslipidemia and the accumulation of lipids in non-adipose tissue, including skeletal muscle. Puerarin, which a natural isoflavonoid isolated from root plant Pueraria lobata, has been shown to have antidiabetic activity. However, lipid-reducing effect puerarin, particular muscle, not yet addressed.We examined puerarin on mitochondrial function oxidation fatty acids muscle high-fat diet/streptozotocin-induced diabetic rats.Puerarin effectively alleviated...
Epidemiological research has indicated a relationship between infant formula feeding and increased risk of chronic diseases later in life including obesity, type-2 diabetes, cardiovascular disease. The present study used an rhesus monkey model to compare the comprehensive metabolic implications formula- breast-feeding practices using NMR spectroscopy characterize metabolite fingerprints from urine serum, combination with anthropometric measurements, fecal microbial profiling, cytokine...
The polycystic ovary syndrome (PCOS) is a common metabolic and endocrine disorder with pathological mechanisms remain unclear. following study investigates the ovarian hyperfibrosis forming via transforming growth factor-β (TGF-β) signaling pathway in Dehydroepiandrosterone (DHEA)- induced rat model. We furthermore explored whether TGF-βRI inhibitor (SB431542) decreases fibrosis by counterbalancing expression of fibrotic biomarkers.Thirty female Sprague-Dawley rats were randomly divided into...
Abstract Formula-fed (FF) infants exhibit a different metabolic profile than breast-fed (BF) infants. Two potential mechanisms are the higher protein level in formula compared with breast milk and removal of fat associated globule membranes (MFGM) during production infant formula. To determine whether MFGM may impact metabolism, formula-fed were randomly assigned to receive either an isolate-supplemented experimental (EF) or standard (SF) from 2 until 6 months BF reference group. Infants...
ABSTRACT Objectives: Rhesus macaque monkeys are widely used as models for human physiology and behavior. They particularly suited studies on infant nutrition metabolism; however, few have directly compared their metabolic or microbiological phenotypes. The aim of the present study was to compare metabolomic profiles microbiome milk from rhesus mothers, urine serum infants establish value this model research. Methods: Milk samples were collected mothers at similar stages lactation. Urine...
Lactose intolerance is a major concern driving the growth of lactose-free foods including infant formula. It unknown what metabolic consequence consumption formula where lactose has been replaced with corn syrup solids (CSS). Here, randomized double-blinded intervention study was conducted exclusively formula-fed infants were fed containing either or CSS-based and compared an equal number breast-fed infants. Plasma metabolites insulin measured at baseline, 15, 30, 60, 90 120 min after...
Cornea confocal microscopy (CCM) is a novel non-invasive method to detect small nerve fiber pathology. CCM generally correlates with outcomes of skin biopsies in patients The aim this study was quantify the morphology fibers cornea fibromyalgia terms density, length and branching further phenotype these using standardized quantitative sensory testing (QST). Small pathology detected 51% patients: significantly decreased 44% compared age- sex-matched reference values; density were 10% 28%...
YKL-40, a chitinase-like protein mainly secreted by macrophages, neutrophils and epithelial cells, is increased in patients with idiopathic interstitial pneumonia sarcoidosis. We aimed to investigate the role of YKL-40 as biomarker hypersensitivity pneumonitis (HP). 72 HP patients, 100 lung disease (ILD) controls 60 healthy were studied. was measured ELISA serum bronchoalveolar lavage fluid (BALF) at baseline follow-up. The relationship between levels, clinical variables outcome evaluated....
Propofol-sufentanil is often used in clinical anesthesia for patients undergoing sedative gastroscopy, but there are still adverse events such as longer recovery time, respiratory depression and higher doses of propofol etc. This study was to evaluate the effect remimazolam-propofol-sufentanil gastroscopy.Patients who were going have gastroscopy examination randomly divided into two groups: group RM (remimazolam-propofol-sufentanil group) PR (propofol-sufentanil group). Patients each...
The objective of this study is to describe the incidence injuries and illnesses sustained during Beijing Winter Olympic Games from 4 February 2022 20 2022.We recorded daily number athlete (1) through reporting all National Committee (NOC) medical teams (2) in polyclinic venues by staff.In total, 2848 athletes (1276 women, 45%; 1572 men, 55%) 91 NOCs were followed prospectively for occurrence injury illness. NOC staff reported 289 109 illnesses, equalling 10.1 3.8 per 100 over 17-day period....
Human milk offers significant health benefits for infants; however, when not feasible, infant formula serves as an alternative. The higher protein content in is thought to contribute the distinct metabolic profiles observed formula-fed infants compared those fed human milk. This study investigates impact of quantity and whey types on serum, urine, fecal metabolomes infants. A secondary analysis was performed a random subset 200 well-characterized per-protocol who completed prospective,...
Ursolic acid (UA) is a triterpenoid compound with multifold biological functions. Our previous studies have reported that UA protects against high-fat diet-induced obesity and improves insulin resistance (IR). However, the potential mechanisms are still undefined. Free fatty (FFA) metabolism in skeletal muscle plays central role IR. Therefore, this study, we investigated effect of on FFA metabolism.In obese rats, 0.5% supplementation for 6 weeks markedly reduced body weight, increased energy...
Nopal is a cactus plant widely consumed in Mexico that has been used traditional medicine to aid the treatment of type-2 diabetes. We previously showed chronic consumption dehydrated nopal ameliorated hepatic steatosis obese (fa/fa) rats; however, description effects on other tissues sparse. The aim present study was investigate cladode intestinal physiology, microbial community structure, adipose tissue, and serum biochemistry diet-induced rats. Rats were fed either normal fat (NF) diet or...