A5101484902- Bone Metabolism and Diseases
- Bone health and treatments
- Mesenchymal stem cell research
- Bone and Joint Diseases
- Spine and Intervertebral Disc Pathology
- Osteoarthritis Treatment and Mechanisms
- Magnetic Properties of Alloys
- Magnetic properties of thin films
- Bone Tissue Engineering Materials
- Connective tissue disorders research
- Fibroblast Growth Factor Research
- Magnetic Properties and Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related molecular mechanisms research
- Bone health and osteoporosis research
- Immune cells in cancer
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Inflammation biomarkers and pathways
- Osteomyelitis and Bone Disorders Research
- Metabolomics and Mass Spectrometry Studies
- Heterotopic Ossification and Related Conditions
- Light effects on plants
- Autophagy in Disease and Therapy
- Telomeres, Telomerase, and Senescence
- Infectious Diseases and Tuberculosis
Sichuan University
2025
Air Force Medical University
2001-2024
Xijing Hospital
2015-2024
Inner Mongolia Normal University
2024
Jinan University
2023
Yunnan University
2023
Xi'an Honghui Hospital
2020
Xi'an Jiaotong University
2018-2020
National Institutes of Health
2020
Yale University
2020
Summary Aging drives the accumulation of senescent cells (SnCs) including stem/progenitor in bone marrow, which contributes to aging‐related degenerative pathologies. Local elimination SnCs has been shown as potential treatment for diseases. As LepR + mesenchymal ( MSPC s) marrow are major population forming bone/cartilage and maintaining HSC s niche, whether local delays pathologies improves microenvironment need be well defined. In this study, we performed delivery tetramethylpyrazine TMP...
Glucocorticoid-induced osteoporosis (GIOP) is a widespread clinical complication due to the common use of glucocorticoids. Excess glucocorticoids induce apoptosis bone marrow-derived mesenchymal stem cells (BMSCs), which have been shown play an increasingly important role in pathogenesis and therapy osteoporosis. Tetramethylpyrazine (TMP), extract from one most recognized herbs traditional Chinese medicine (Chuanxiong), has reported antiapoptotic properties. In this study, we tested whether...
Abstract Free fatty acids display diverse effects as signalling molecules through GPCRs in addition to their involvement cellular metabolism. GPR120, a G protein-coupled receptor for long-chain unsaturated acids, has been reported mediate adipogenesis lipid However, whether GPR120 also mediates osteogenesis and regulates BMMSCs remain unclear. In this study, we showed that targeted the bi-potential differentiation of ligand dose-dependent manner. High concentrations TUG-891 (a highly...
Mutations in the SLC26A2 gene cause a spectrum of currently incurable human chondrodysplasias. However, genotype-phenotype relationships SLC26A2-deficient chondrodysplasias are still perplexing and thus stunt therapeutic development.To investigate causative role deficiency confirm its skeleton-specific pathology, we generated analyzed slc26a2-/- Col2a1-Cre; slc26a2fl/fl mice. The effect NVP-BGJ398, an FGFR inhibitor, was tested with both explant cultures timed pregnant females.Two lethal...
Abstract Long-term use of glucocorticoids is a widespread clinical problem, which currently has no effective solution other than discontinuing the use. Eicosapentaenoic acid (EPA), an omega-3 long chain polyunsaturated fatty (n-3 PUFA), largely contained in fish or oil, been reported to promote cell viability and improve bone metabolism. However, little known about effects EPA on dexamethasome (Dex)-induced apoptosis. In this study, we showed that EPA-induced autophagy murine marrow-derived...
Abstract Background Induced pluripotent stem cells (iPSCs) exhibit limitless plasticity and proliferation capability to provide an abundant cell source for tissue regenerative medicine. Thus, inducing iPSCs toward a specific differentiation direction is important scientific question. Traditionally, have been induced chondrocytes with the help of some small molecules within 21–36 days. To speed up iPSCs, we supposed utilize bioactive ceramics assist chondrogenic-induction process. Methods In...
Osteoporosis is a common disorder characterized by decreased bone mineral density (BMD) and increased fracture risk. The current techniques detect real‑time BMD precisely but do not provide adequate information to predict early loss. If loss could be diagnosed predicted early, severe osteoporosis unexpected fractures prevented, allowing for an improved quality of life individuals. In the present study, ovariectomized rat model was established serum levels 78 potential cytokines were...
Postmenopausal osteoporosis is one of the most prominent worldwide public health problems and morbidity increasing with aging population. It has been demonstrated that early diagnosis intervention delay disease progression improve outcome. Therefore, searching for biomarkers are able to identify postmenopausal women at high risk developing an effective way quality life patients, alleviate social economic burdens. In present study, a protein array was used potential biomarkers. The bone...
Introduction: Developmental engineering based on endochondral ossification has been proposed as a potential strategy for repairing of critical bone defects. Bone development is driven by growth plate-mediated ossification. Under physiological conditions, plate chondrocytes undergo compressive forces characterized micro-mechanics, but the regulatory effect micro-mechanical loading formation not investigated. Methods: In this study, periodic static compression (PSC) model micro-strain (with...
Among the largest transcription factor families in plants, bZIPs are crucial for various developmental and physiological processes, particularly abiotic stress resistance.
Mesenchymal progenitors within bone marrow have multiple differentiation potential and play an essential role in the maintenance of adult skeleton homeostasis. located regions other than also display bone-forming properties. However, owing to differences each distinct microenvironment, mesenchymal characteristics skeletal progenitor cells different long bones may show some differences. In order clearly elucidate these differences, we performed a comparative study on from bones. Here,...
Oxymatrine, also known as ammothamnine or oxysophoridine, is a natural compound isolated from Sophora flavescens (in Chinese, Kushen), and many previous researchers have characterized its anti-inflammatory, anti-fibrotic anti-tumor properties. However, the underlying immunological mechanism of oxymatrine remains elusive. In this study, we carried out experiments both in vitro vivo investigated effect to inhibit proliferation migration melanoma B16 cells, while promoting apoptosis. Oxymatrine...
Long‑term glucocorticoid therapy results in various side effects, including a high incidence of glucocorticoid‑induced osteoporosis (GIOP), which is the most common form secondary osteoporosis. Excess glucocorticoids reduce viability bone marrow‑derived mesenchymal stem cells (BMSCs) and prolong osteoclast survival. These two types cell are essential balance between formation resorption. Tetramethylpyrazine (TMP), pharmacologically active component extracted from Chuanxiong, has been...
To examine the changes in plasma microparticle (MP) levels patients after intracerebral hemorrhage (ICH) and assess their association with outcome along biological markers of acute phase response.Thirty healthy controls 86 ICH were recruited. Plasma samples obtained on admission at days 1, 2, 3, 5, 7 ICH. MPs procoagulant potential measured a prothrombinase assay.Plasma MP substantially higher than those during 7-day period. strongly associated response. Multivariate analysis showed baseline...
Abstract Confusion persists over pathogenesis of spondylolysis. To confirm pathogenicity the previously identified causative mutation spondylolysis and investigate genetic etiology, we generate a new mouse line harboring D673V in Slc26a2 gene. induces delayed endochondral ossification characterized by transiently reduced chondrocyte proliferation mice at early postnatal stage. Adult homozygotes exhibit dysplastic isthmus bone volume dorsal vertebra resembling detached vertebral bony...
We have developed a new drug-delivery system using reconstituted bone xenograft to treat chronic osteomyelitis. This material, which has the capabilities of osteoinduction and osteoconduction, was supplemented with up 2000 times minimum inhibitory concentration gentamicin against Staphylococcus aureus prepare gentamicin-reconstituted xenograft-composite (G-RBX-C). In rabbit model, we evaluated release from this composite in vivo, its capability for induction ectopic repair segmental defects...