A5075034592- Phytoplasmas and Hemiptera pathogens
- Plant Reproductive Biology
- Cancer-related molecular mechanisms research
- Osteoarthritis Treatment and Mechanisms
- RNA Interference and Gene Delivery
- Phytochemicals and Antioxidant Activities
- Antioxidant Activity and Oxidative Stress
- Fungal Biology and Applications
- Mycorrhizal Fungi and Plant Interactions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Trace Elements in Health
- Autophagy in Disease and Therapy
- Cocoa and Sweet Potato Agronomy
- Cancer-related gene regulation
- Diet and metabolism studies
- Virus-based gene therapy research
- Dialysis and Renal Disease Management
- Peroxisome Proliferator-Activated Receptors
- Plant Pathogenic Bacteria Studies
- Entomopathogenic Microorganisms in Pest Control
- GABA and Rice Research
- RNA Research and Splicing
- Plant-Microbe Interactions and Immunity
- Selenium in Biological Systems
- Plant pathogens and resistance mechanisms
University of California, Irvine
2019-2025
East China Normal University
2025
Children's Hospital of Fudan University
2024-2025
Institute of Genetics and Developmental Biology
2025
Chinese Academy of Sciences
2025
Hebei University
2025
Xi'an Jiaotong University
2018-2024
Shanghai Lixin University of Accounting and Finance
2024
Hubei University
2024
Anhui University of Science and Technology
2023-2024
BackgroundIn 2009, severe fever with thrombocytopenia syndrome virus (SFTSV) was identified as a novel member of the genus phlebovirus in Bunyaviridae family China. The detailed clinical features cases SFTSV infection have not been well described, and risk factors for severity among patients fatality remain to be determined. Methodology/Principal FindingsClinical laboratory 115 hospitalized during period from June 2010 December 2011 Northeast China were retrospectively reviewed. We assessed...
Defective macroautophagy/autophagy and mitochondrial dysfunction are known to stimulate senescence. The regulator PPARGC1A (peroxisome proliferator activated receptor gamma, coactivator 1 alpha) regulates biogenesis, reducing senescence of vascular smooth muscle cells (VSMCs); however, it is unknown whether autophagy mediates PPARGC1A-protective effects on Using
Severe fever with thrombocytopenia syndrome virus (SFTSV), which can cause hemorrhagic fever-like illness, is a newly discovered bunyavirus in China. The pathogenesis of SFTSV infection poorly understood. However, it has been suggested that immune mechanisms, including cytokines and chemokines, play an important role disease pathogenesis. In the present study, we investigated host cytokine chemokine profiles serum samples patients from Northeast China explored possible correlation between...
Abstract Background Chronic kidney disease (CKD) is increasingly recognized as a stroke risk factor, but its exact relationship with cerebrovascular not well-understood. We investigated the development of cerebral small vessel using in vivo and vitro models CKD. Methods CKD was produced aged C57BL/6J mice an adenine-induced tubulointerstitial nephritis model. analyzed brain histology Prussian blue staining to examine formation microhemorrhage (CMH), hemorrhagic component neuropathological...
Blackberry, raspberry and black polyphenols reduce angiotensin II-induced oxidative stress senescence of vascular smooth muscle cells.
After China lifted strict COVID-19 control measures, the winter of 2023 saw widespread outbreaks emerging infectious diseases, including various strains influenza, mycoplasma pneumonia, and COVID-19. These diseases have heightened risk repeated infections severe illness, making health communication strategies increasingly important for promotion. While most studies focus on message dissemination by authorities experts, role patient-generated content, shared individuals with firsthand...
Cardiovascular disease (CVD) is the leading cause of death among patients with chronic kidney (CKD). Rodent models are widely used to study uremic CVD pathophysiology. We compared cardiac function parameters in male and female animals from 2 established mouse CKD examined associations between gut-derived toxins echocardiogram findings. Male adult C57Bl/6J mice were randomly assigned control, adenine-induced 5/6 nephrectomy groups. Echocardiography was performed on all at age 17 weeks (5...
The solute carrier 30A ( SLC30A ) family of zinc exporters transports into the lumen intracellular organelles in order to prevent toxicity. We reported that formation tyrosine dimers is required for ZnT3 (zinc transporter 3) transport activity and targeting synaptic‐like microvesicles SLMVs PC12 cells / ZnT10 heterodimers. Here, we focused on determine role heterodimerization sorting ZnTs endolysosomal pathway. Using cell fractionation, immunoprecipitation immunofluorescence approaches,...
Osteoarthritis (OA) is a degenerative disease of articular cartilage that mainly characterized by chronic and mild inflammation the joints. Recently, many studies have reported crucial roles long noncoding RNAs (lncRNAs) in OA as gene transcriptional regulatory factors, diagnostic biomarkers, or therapeutic targets. However, exact mechanisms lncRNAs regulation progression remain unclear. In present study, lncRNA WDR11 divergent transcript (lncRNA WDR11-AS1) was shown to be downregulated...
The WRKY gene family is one of the most important families in higher plants. As transcription factors, they actively respond to biotic and abiotic stress are also involved plant development. Chinese jujube (Ziziphus jujuba Mill.) largest type dried fruit tree China terms production, but its production largely limited by phytoplasma infection, information about role genes under was still limited.We identified 54 ZjWRKYs genome classified them into three subgroups according conserved domains...
Pleurotus eryngii (King Oyster) is one of the most highly prized edible mushrooms. Among diverse varieties within P. eryngii, var. commonest one, with a worldwide distribution, while ferulae only distributed in Europe and China, especially adapted to Gobi Desert Xinjiang Autonomous Region China. However, little known about genome-wide pattern evolution adaptation divergent environments eryngii. Here, we present high-quality genome sequences strain PEE81 originating from PEF12 The assembled...
Abstract Osteoarthritis (OA) is the most common form of arthritis involving major structural changes peripheral joints and local or systemic inflammation in lack therapeutic approaches because complexity underlying molecular basis. Our previous work showed that HS6ST2, an enzyme involved transfer sulfate, downregulated cartilage tissues OA patients compared with normal donors, but little known about its regulatory mechanism. In this study, we demonstrated expression HS6ST2 was lower...
Extensive efforts have been dedicated to enhancing the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in cancer cells for development effective treatments. However, highly safe and efficient delivery TRAIL gene remains a significant challenge, especially using cationic polymers. Here, series branched-linear poly(β-amino ester)s (H-LPAEs) are developed through unique oligomer branching strategy. H-LPAEs exhibit more uniform distribution linear segments units,...
Gene therapy has emerged as a potent tool for treating wide range of hereditary and acquired disorders. However, the development high-performance nonviral gene delivery vectors remains significant challenge. Here we report new type star-shaped poly(β-amino ester) (SPAE) through "top-down" hydrolysis approach demonstrate its exceptional DNA transfection efficiency safety profiles. Two SPAEs with different monomer combinations are first synthesized using an "arm first" strategy then hydrolyzed...
Anthocyanin is a flavonoid compound with potential antioxidant properties beneficial to human health and sustains plant growth development under different environmental stresses. In black rice, anthocyanin can be found in the stems, leaves, stigmas, caryopsis. Although biosynthesis rice has been extensively studied, limited knowledge underlying storage mechanism transporters available. This study undertook complementation of computational transcriptome analysis decipher multidrug toxic...