A5056785523- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Advanced Polymer Synthesis and Characterization
- Electromagnetic wave absorption materials
- Biopolymer Synthesis and Applications
- Dendrimers and Hyperbranched Polymers
- Virus-based gene therapy research
- Nanoparticle-Based Drug Delivery
- Polymer Surface Interaction Studies
- Advanced Battery Materials and Technologies
- Graphene and Nanomaterials Applications
- Advanced Antenna and Metasurface Technologies
- Advanced battery technologies research
- Polymer composites and self-healing
- Conducting polymers and applications
- Surface Modification and Superhydrophobicity
- Pluripotent Stem Cells Research
- Bacteriophages and microbial interactions
- Nanoplatforms for cancer theranostics
- biodegradable polymer synthesis and properties
- MXene and MAX Phase Materials
- Immunotherapy and Immune Responses
- Fuel Cells and Related Materials
- Photonic Crystals and Applications
- Silk-based biomaterials and applications
Xi'an Jiaotong University
2022-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2025
Tianjin University
2018-2019
University College Dublin
2018-2019
Institute of Dermatology
2019
Abstract Inspired by the lotus leaf in nature, superhydrophobic materials have attracted considerable attention both science and industry over past three decades. Apart from most characteristic yet widely used properties such as waterproofing, anti‐fouling, self‐cleaning, also developed exciting new functions drag reduction, corrosion resistance, anti‐icing, anti‐bacteria, anti‐reflection. In this review article, theoretical models describing surfaces are first briefly introduced. Then,...
Development of mRNA therapeutics necessitates targeted delivery technology, while the clinically advanced lipid nanoparticles face difficulty for extrahepatic delivery. Herein, we design highly branched poly(β-amino ester)s (HPAEs) efficacious organ-selective through tailoring their chemical compositions and topological structures. Using an "A2+B3+C2" Michael addition platform, a combinatorial library 219 HPAEs with varied backbone structures, terminal groups, branching degrees are...
Proteins have tremendous potential for vaccine development and disease treatment, but multiple extracellular intracellular biological barriers must be overcome before they can exert specific functions in the target tissue. The use of polymers as carriers would greatly improve their bioavailability therapeutic efficiency. Nevertheless, effective protein packaging cell membrane penetration without causing cytotoxicity is particularly challenging, due largely to simultaneous distribution...
Topological structure plays a critical role in gene delivery of cationic polymers. Cyclic poly(β-amino ester)s (CPAEs) are successfully synthesized via sequential Michael addition and free radical initiating ring-closure reaction. The CPAEs exhibit superior transfection efficiency safety profile compared to their linear counterparts.
Poly(β-amino ester)s (PAEs) have been widely developed for gene delivery, and hydrophobic modification can further enhance their transfection efficiency. However, systematic manipulation of amphiphilicity PAEs through copolymerization with monomers is time-consuming and, to some extent, uncontrollable. Here, a modular strategy manipulate the PAE/DNA polyplexes. A polymer (DD-C12-122) hydrophilic (DD-90-122) are synthesized separately used as module module, respectively. The polyplexes could...
mRNA therapeutics hold tremendous promise for disease prevention and treatment. Development of high-performance delivery systems with enhanced transfection efficiency a safety profile will further fulfill their therapeutic potential expedite translation. The synthesis "four-in-one" highly branched poly(β-amino ester)s (O-LhPAEs) is reported by integrating the essential components lipid nanoparticles (LNPs) spleen-selective enrichment nebulization treatment silicosis. 60 O-LhPAEs distinct...
Multifunctional hyperbranched poly(poly(ethylene glycol) diacrylate) (HB-PEGDA) polymers with well-defined composition, structure, and functionality are proposed in this work as photonic hydrogel scaffolds. By taking advantage of its unique transparency, low intrinsic viscosity, high amount vinyl groups, the HB-PEGDA can effectively penetrate inside colloidal crystal (CPC) substrate be cross-linked thiolated hyaluronic acid very quickly. This shows not only an unexpected protective effect to...
Biodegradable and lipid-like highly branched poly(β-amino ester)s, HPAESA, were developed to enhance the biological functions of adipose-derived stem cells by gene transfection. Biodegradability reduces cytotoxicity HPAESA enables controlled DNA release. Lipid mimicry enhances cellular uptake endosomal escape HPAESA/DNA polyplexes. are able transfect rat (rADSs) human ADSCs (hADSCs) with orders magnitude higher efficiency than commercial transfection reagents, cell viability exceeding 90%....
Abstract To date, significant efforts have been dedicated to improve their ionic conductivity, thermal stability, and mechanical strength of solid polymer electrolytes (SPEs). However, direct monitoring physical chemical changes in SPEs is still lacking. Moreover, existing thermosetting are hardly degradable. Herein, by overcoming the limitation predicted Flory theory, self‐reporting biodegradable hyperbranched poly(β‐amino ester)‐based (HPAE‐SPEs) reported. HPAE successfully synthesized...
Electromagnetic interference (EMI) shielding is essential for protecting the biological and electronic devices from electromagnetic waves.
Cancer therapy is a global biomedical challenge, and number of promising anticancer therapeutics, such as small-molecule drugs, proteins, nucleic acids, photothermal agents, etc., have been developed or are in development. However, the direct administration therapeutics often fails to achieve desired therapeutic efficacy due their low bioavailability poor tissue selectivity, leading relapse severe side effects immunosuppression, chronic inflammatory responses, mutagenesis, long-term...
Branched polymers exhibit a unique three-dimensional (3D) molecular architecture and distinctive physical/chemical properties, thus have been applied in wide variety of fields.
Gene therapy has emerged as a promising strategy for treating various hereditary cutaneous disorders. However, the entrapment of nucleic acids in endosomes is significant hurdle. Here we synthesized endoplasmic reticulum (ER)-targeting highly branched poly(β-amino ester)s (ER-HPAEs) and investigated their potential skin gene delivery. The incorporation methyl-benzenesulfonamide (NMS) moieties endowed ER-HPAEs with strong ER-targeting ability, allowing ER-HPAE/DNA polyplexes to bypass...