A5063540016- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood disorders and treatments
- Hemoglobinopathies and Related Disorders
- Immunodeficiency and Autoimmune Disorders
- Bacterial Infections and Vaccines
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nanoparticle-Based Drug Delivery
- Immune Response and Inflammation
- Advanced Drug Delivery Systems
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Impact on Reproduction
- Platelet Disorders and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Complement system in diseases
- Blood Coagulation and Thrombosis Mechanisms
- Immune Cell Function and Interaction
- Antibiotic Use and Resistance
- Extracellular vesicles in disease
Children's Hospital of Philadelphia
2020-2024
Philadelphia University
2024
University of Pennsylvania
2020-2021
Complement opsonization is among the biggest challenges facing nanomedicine. Nearly instantly after injection into blood, nanoparticles are opsonized by complement protein C3, leading to clearance phagocytes, fouling of targeting moieties, and release anaphylatoxins. While surface polymers such as poly(ethylene glycol) (PEG) partially decrease opsonization, most still suffer from extensive especially when linked moieties. To ameliorate deleterious effects complement, two mammals' natural...
Abstract Acute lung inflammation has severe morbidity, as seen in COVID-19 patients. Lung is accompanied or led by massive accumulation of neutrophils pulmonary capillaries (“margination”). We sought to identify nanostructural properties that predispose nanoparticles accumulate marginated neutrophils, and therefore target severely inflamed lungs. designed a library conducted an vivo screen biodistributions naive mice treated with lipopolysaccharides. found supramolecular organization protein...
Recurrent infections are a hallmark of STAT3 dominant-negative hyper-IgE syndrome (STAT3 HIES), rare immunodeficiency previously known as Jobs syndrome, along with elevated IgE levels and impaired neutrophil function. We have been developing nanoparticles trophism that home to the sites infection via these first-responder leukocytes, named neutrophil-avid nanocarriers (NANs). Here, we demonstrate human neutrophils can phagocytose nanogels (NGs), type NAN, enhanced uptake after particle serum...
Despite the power of antibiotics, bacterial infections remain a major killer, due to antibiotic resistance and hosts with dysregulated immune systems. We others have been developing drug-loaded nanoparticles that home sites infection inflammation via engineered tropism for neutrophils, first-responder leukocytes in infections. Here, we examined how member broad class neutrophil-tropic affects neutrophil behavior, specifically questioning whether attenuate an important function, phagocytosis....
Extreme thrombocytosis (ET, platelet count >1000 × 10 3 /ul) is an uncommon clinical finding 1. Primary ET associated with myeloproliferative disorders, such as essential thrombocythemia 2. Secondary more common and occurs in reaction to infection, inflammation, or iron deficiency. Bleeding thrombotic complications frequently arise primary cases 1, but have been reported secondary adults 3. Etiologies children are less well-defined, prior pediatric studies relatively small restricted...
Abstract Despite the power of antibiotics, bacterial infections remain a major killer, due to antibiotic resistance and hosts with dysregulated immune systems. We others have been developing drug-loaded nanoparticles that home sites infection inflammation via engineered tropism for neutrophils, first-responder leukocytes in infections. Here, we examined how member broad class neutrophil-tropic affects neutrophil behavior, specifically questioning whether attenuate an important function,...