A5063861565- Parasites and Host Interactions
- Toxoplasma gondii Research Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Immune cells in cancer
- interferon and immune responses
- Parasitic Infections and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Liver Diseases and Immunity
- Drug Transport and Resistance Mechanisms
- Liver physiology and pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Trace Elements in Health
- Innovations in Medical Education
- Parasitic infections in humans and animals
- Angiogenesis and VEGF in Cancer
- Tryptophan and brain disorders
- Vector-borne infectious diseases
- IL-33, ST2, and ILC Pathways
- Redox biology and oxidative stress
- Viral gastroenteritis research and epidemiology
- Sex work and related issues
- Immune Response and Inflammation
- Helminth infection and control
- Amoebic Infections and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Peking Union Medical College Hospital
2025
Xuzhou Medical College
2015-2024
Immunité et Cancer
2017
Nanjing Medical University
2005
JOURNAL/nrgr/04.03/01300535-202409000-00042/figure1/v/2024-01-30T062302Z/r/image-tiff Parkinson's disease is a neurodegenerative characterized by motor and gastrointestinal dysfunction. Gastrointestinal dysfunction can precede the onset of symptoms several years. Gut microbiota dysbiosis involved in pathogenesis disease, whether it plays causal role dysfunction, mechanism underlying this potential effect, remain unknown. CCAAT/enhancer binding protein β/asparagine endopeptidase (C/EBPβ/AEP)...
Background Chronic infection with the neurotropic parasite Toxoplasma gondii (T. gondii) can cause anxiety and gut microbiota dysbiosis in hosts. However, potential role of induced by remains unclear.
Probiotics might offer an attractive alternative to prevent and control Clostridium difficile (C. difficile) infection (CDI). Limited information is available on the ability of commercially used bifidobacterial strains inhibit C. difficile. This study examined anti-clostridial effects Bifidobacterium longum JDM301 (JDM301), a widely commercial probiotic strain in China, vitro vivo. In evaluation revealed significant reduction counts when was co-cultured with difficile, which correlated...
Significance Hepatic fibrosis is the final common pathological outcome of many chronic liver diseases and occurs when hepatic stellate cells (HSCs) are activated to become fibrogenic myofibroblasts. To date, there still no approved antifibrotic therapies. Accumulating evidence suggests that targeting deregulated miRNAs could mitigate disease outcomes. In this study, using a well-studied model human schistosomiasis, we show elevated miR-351 promotes activation HSCs after infection by vitamin...
Liver fibrosis is a hallmark of clonorchiasis suffered by millions people in Eastern Asian countries. Recent studies showed that the activation TGF-β/Smad signaling pathway can potently regulate hepatic fibrogenesis including Schistosoma spp. and Echinococcus multilocularis-caused liver fibrosis. However, little known to date about expression transforming growth factor-β (TGF-β) other molecules which may play an important role caused C. sinensis. A total 24 mice were individually infected...
A high-fat (HF) diet alters gut microbiota and promotes obesity related inflammation cognitive impairment. Teasaponin is the major active component of tea, has been associated with anti-inflammatory effects improved composition. However, potential protective teasaponin, against HF diet-induced its alteration microbiota, decline have not studied. In this study, was induced in C57BL/6 J male mice by feeding a for 8 weeks, followed treatment oral teasaponin (0.5%) mixed further 6 weeks....
Excretory-secretory products (ESPs) released by helminths are well-known to regulate T cell responses in the host. However, their direct influence differentiation of naïve cells, and especially B remains largely unknown. This study investigated effects Echinococcus granulosus protoscoleces ESPs (EgPSC-ESPs) on IL-10-producing cells (B10), IL-17A-producing (B17) Th17 cells.BALB/c mice injected with EgPSC were used evaluate vivo profiles B10, B17 cells. In vitro purified CD19+ CD4+ cultured...
Hepatic steatosis is a major health issue that can be attenuated by healthy diet. This study investigates the effects and molecular mechanisms of butyrate, dietary fiber metabolite gut microbiota, on lipid metabolism in hepatocytes.
Neurotransmitter receptors are increasingly recognized to play important roles in anti-tumor immunity. The expression of the ion channel N-methyl-D-aspartate receptor (NMDAR) on macrophages was reported, but role NMDAR tumor microenvironment (TME) remains unknown. Here, we show that activation triggered calcium influx and reactive oxygen species production, which fueled immunosuppressive activities tumor-associated (TAMs) hepatocellular sarcoma fibrosarcoma settings. antagonists, MK-801,...
Synanthropic rats and mice share the same environment with humans play an important role in epidemiology of toxoplasmosis; however, there is limited information about prevalence genetic characterization Toxoplasma gondii synanthropic China. In present study, T. naturally infected rodents (Rattus norvegicus Mus musculus) were investigated urban area Xuzhou city, Eastern China between June 2013 August 2014. DNA from brain each animal was prepared screened by specific PCR assay targeting...
Abstract Ischemic postconditioning provides robust neuroprotection, therefore, determining the molecular events may provide promising targets for stroke treatment. Here, we showed that expression of functional mitochondrial voltage-dependent anion channel proteins (VDAC1, VDAC2, and VDAC3) reduced in rat vulnerable hippocampal CA1 subfield after global ischemia. restored VDACs to physiological levels. Stabilized contributed benefits postconditioning. VDAC1 was required maintaining neuronal...
Introduction: Clonorchis sinensis is one of the most important foodborne pathogens in humans, and can cause biliary diseases such as gallstones, cholecystitis, cholangitis, cholangiocarcinoma. Toll-like receptors (TLRs) sensors are crucial to initiating both innate adaptive immune defenses against pathogens. However, little known about hepatic expression TLRs hosts induced by C. infection. Methodology: In present study, distribution TLR2 TLR4 were investigated a mouse model clonorchiasis on...
Abstract Targeting C5aR1 modulates the function of infiltrated immune cells including tumor-associated macrophages (TAMs). The gut microbiome plays a pivotal role in colorectal cancer (CRC) tumorigenesis and development through TAM education. However, whether how flora is involved inhibition-mediated TAMs remains unclear. Therefore, this study, genetic deletion C5ar1 or pharmacological inhibition with anti-C5aR1 Ab PMX-53 presence absence Abs were utilized to verify if regulated polarization...
Abstract Background Toxoplasmosis is an important parasitic zoonosis caused by the protozoan Toxoplasma gondii that distributed world-wide and infects a variety of hosts. However, prevalence T. in environment (such as soil, water food) largely unknown. Due to technical difficulty oocyst counting directly, alternative assay using serologic status free-living animals, such stray or dogs, indicator, can be used evaluate environmental contamination indirectly, they are exposed same risk...
Previous studies showed that CD4+T cells responses might be involved in the process of biliary fibrosis. However, underlying mechanism resulting fibrosis caused by Clonorchis sinensis remains not yet fully elucidated. The objectives present study were to investigate different profiles hepatic cell subsets (Th1, Th2, Th17 and Treg cells) their possible roles strains mice (C57BL/6, BALB/c FVB mice) induced C. infection. C57BL/6, orally gavaged with 45 metacercariae. All sacrificed on 28 days...