A5041221927- Muscle activation and electromyography studies
- Neurological Disorders and Treatments
- RNA modifications and cancer
- MicroRNA in disease regulation
- Hernia repair and management
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Spinal Fractures and Fixation Techniques
- Gallbladder and Bile Duct Disorders
- Cancer-related molecular mechanisms research
- Stroke Rehabilitation and Recovery
- Scoliosis diagnosis and treatment
- Nausea and vomiting management
- Neurological Disease Mechanisms and Treatments
- Circular RNAs in diseases
- Ergonomics and Musculoskeletal Disorders
- Migraine and Headache Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Anesthesia and Pain Management
- Surgical site infection prevention
- Flavonoids in Medical Research
- Enhanced Recovery After Surgery
- Traditional Chinese Medicine Analysis
- Pregnancy and Medication Impact
- Cancer Mechanisms and Therapy
Zhongnan Hospital of Wuhan University
2025
Wuhan University
2025
China-Japan Friendship Hospital
2019-2024
Longgang Central Hospital
2018-2024
Xuzhou Medical College
2018-2024
Shanghai Chest Hospital
2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024
Xuzhou Central Hospital
2021-2022
First Affiliated Hospital of Wenzhou Medical University
2013-2021
Wenzhou Medical University
2009-2021
Mounting evidence indicates that microRNAs play important roles in the development of various cancers. Aberrant expression microRNA-199a-5p has been frequently reported cancer studies; however, mechanistic details role colorectal still remain unclear. Our study aimed to explore cells by targeting Rho-associated coiled coil-containing protein kinase 1. Here, we showed was significantly downregulated cell lines and tissue samples associated with a poor prognostic phenotype. MicroRNA-199a-5p...
Objective: This study evaluated the effect of neoadjuvant therapy (NAT) and prognostic significance carcinoembryonic antigen (CEA) levels in patients with non-elevated serum carbohydrate (CA) 19-9 levels. Summary Background Data: The impact NAT followed by surgical resection on oncologic outcomes localized pancreatic ductal adenocarcinoma (PDAC) remains unclear. Methods: retrospective propensity-score matched (PSM) included primary validation cohorts from four centers. Propensity scores were...
Background Adolescent idiopathic scoliosis (AIS) is the most common form of scoliosis. However, underlying mechanisms linking spinal curvature in AIS to foot characteristics and walking performance remain unclear. Objective This study aimed compare between adolescents with mild, moderate, severe matched healthy peers posture as covariates. Methods cross-sectional 96 was conducted April 2020 October China, 32 control group 64 patients group. Foot morphology, plantar pressure distribution,...
Abstract Ischemic postconditioning provides robust neuroprotection, therefore, determining the molecular events may provide promising targets for stroke treatment. Here, we showed that expression of functional mitochondrial voltage-dependent anion channel proteins (VDAC1, VDAC2, and VDAC3) reduced in rat vulnerable hippocampal CA1 subfield after global ischemia. restored VDACs to physiological levels. Stabilized contributed benefits postconditioning. VDAC1 was required maintaining neuronal...
Objective: The purpose of this paper was to study the protective effect paeoniflorin on acute cerebral ischemia. animal model infarction induced by Middle Cerebral Artery Occlusion (MCAO) blocked suture method. Sixty SD rats were randomly divided into shame group, MCAO (60, 120, 240 mg/kg, respectively) and Nimodipine (NMDP) group (n = 10 per group). Methods: intragastrically administered immediately after operation. After 7 days gavage, brains decapitated at 24 h. Hematoxylin Eosin (HE)...
3121 Background: Aldo-keto reductase family 1 member C3 (AKR1C3) modulates cellular differentiation and proliferation through indirect regulation of ligand access to hormone nuclear receptor signaling. AKR1C3 is expressed at high levels in various human cancers, including hepatocellular carcinoma (HCC). AST-3424 an AKR1C3-activated prodrug releases a toxic bis-alkylating moiety (AST-2660) the presence AKR1C3, which forms intra- inter-strand DNA crosslinks resulting cell death. Here we report...
Abstract Background Bracing and exercise methods were used in scoliosis rehabilitation proven effective. There was little evidence about the efficacy of insoles on scoliosis. Objective This study aimed to investigate effects 3D personalized curve magnitude, postural stability, quality life (QOL) moderate adolescent idiopathic (AIS) patients. Methods Thirty-six volunteers with scoliosis, who had curves (20°-45°), randomly divided into experimental control groups. The group received...
Customized static orthoses in rehabilitation clinics often cause side effects, such as discomfort and skin damage due to excessive local contact pressure. Currently, clinicians adjust reduce high pressure based on subjective feedback from patients. However, the adjustment is inefficient prone variability unknown distribution well differences across This paper proposed a new method predict threshold of (pressure limit) associated with moderate at each critical spot under hand orthoses. A...
3002 Background: STAT3 is constitutively activated by growth signaling pathways in many malignancies; cell lines inhibition of leads to death. OPB51602 a small molecule inhibitor phosphorylation (Tyr705) and activation. Methods: A phase I study administered for 2 weeks every 3 was initiated determine the maximum tolerable dose (MTD), evaluate pharmacokinetics (PK), assess pharmacodynamics effects on peripheral blood mononuclear cells (PBMCs). The starting 2mg/day, escalations 5mg/d, 10mg/d,...
<title>Abstract</title> Background Stroke is the main cause of disability and cognitive impairment. The acute phase stroke lasts for about 7 days, which characterized by infiltration immune cells into brain parenchyma, secretion pro-inflammatory cytokines, promotion classical activation these cells. inflammatory greatly increased infarct size neurological deficits in ischemic model mice, exacerbating dysfunction. Patients methods: An inflammation-related disease was established cohort to...
<title>Abstract</title> <bold>Background:</bold> Migraine is a prevalent and disabling neurovascular disorder that poses significant public health challenge worldwide. Currently, there lack of comprehensive analysis regarding the global disease burden evolving trends migraine. <bold>Methods: </bold>Based on latest data from GBD 2021 study, we analyzed incidence, prevalence, disability-adjusted life years (DALYs) associated with migraines at global, regional, national levels 1990 to 2021. We...
Background: Implicit magnitudes and distribution of excessive contact pressures under hand orthoses hinder clinicians from precisely adjusting them to relieve the pressures. To address this, pressure a orthosis were analysed using finite element method. Methods: This paper proposed method numerically predict relatively high critical through analysis, identify locations. The model was established consisting hand, bones. bones assumed be homogeneous elastic bodies, considered as an isotropic...
Abstract Not all MET exon 14 skipping ( ex14) NSCLC patients benefited from inhibitors. We hypothesized an inter-tumoral heterogeneity in ex14 NSCLC. Investigations at genomic and transcriptomic level were conducted samples stage I-III recurrent/metastatic as discovery validation cohort. Four molecular subtypes discovered. MET-Driven subtype, with the worst prognosis, displayed overexpression, enrichment of MET-related pathways, higher infiltration fibroblast regulatory T cells....
Post-stroke depression (PSD) is an emotional disease characterized by loss of interest and after a stroke. Acupuncture, one the most critical non-drug therapies for treatment PSD, has significant clinical efficacy, but mechanism not fully understood. Previous study shown that acupuncture can reduce level proinflammatory cytokines increase anti-inflammatory cytokines, suggesting regulating dynamic balance inflammatory may be basis to improve PSD symptoms.