A5070255663- Advanced Causal Inference Techniques
- Advanced biosensing and bioanalysis techniques
- Statistical Methods and Inference
- Hearing, Cochlea, Tinnitus, Genetics
- Graphene and Nanomaterials Applications
- MXene and MAX Phase Materials
- Health Systems, Economic Evaluations, Quality of Life
- Geological and Geochemical Analysis
- Hearing Loss and Rehabilitation
- Geological formations and processes
- Cancer-related molecular mechanisms research
- Geology and Paleoclimatology Research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Gut microbiota and health
- RNA Interference and Gene Delivery
- Healthcare Policy and Management
- Fungal Plant Pathogen Control
- Neurological Disorders and Treatments
- Brain Tumor Detection and Classification
- Emotion and Mood Recognition
- Genetic Associations and Epidemiology
- Energy Efficiency and Management
- Vehicle Routing Optimization Methods
Shandong University
2022-2025
Southeast University
2021-2025
Nanjing Agricultural University
2024
Second Affiliated Hospital of Zhejiang University
2022-2024
Zhejiang University
2022-2024
Central Hospital of Zibo
2024
Northeastern University
2024
Shihezi University
2024
Jilin University
2022-2023
Beijing Institute of Technology
2023
Myosin VI(MYO6) is an unconventional myosin that vital for auditory and vestibular function. Pathogenic variants in the human MYO6 gene cause autosomal-dominant or -recessive forms of hearing loss. Effective treatments Myo6 mutation causing loss are limited. We studied whether adeno-associated virus (AAV)-PHP.eB vector-mediated vivo delivery Staphylococcus aureus Cas9 (SaCas9-KKH)-single-guide RNA (sgRNA) complexes could ameliorate a Myo6WT/C442Y mouse model recapitulated phenotypes...
The ideal neural interface or scaffold for stem cell therapy shall have good biocompatibility promoting survival, maturation and integration of cells (NSCs) in targeted brain regions. unique electrical, hydrophilic surface-modifiable properties Ti3C2Tx MXene make it an attractive substrate, but little is known about how interacts with NSCs during development maturation.In this study, we cultured on examined its effects morphological electrophysiological NSC-derived neurons. With a...
Endolymphatic potential (EP) is the main driving force behind sensory transduction of hearing, and K + charge carrier. Kir5.1 a transporter that plays significant role in maintaining EP homeostasis, but expression pattern (which encoded by Kcnj16 gene) mouse auditory system has remained unclear. In this study, we found was expressed cochlea. We checked inner ear morphology measured function –/– mice loss did not appear to affect development hair cells. There no difference between wild-type...
New energy is gradually replacing fossil and becoming the main source of electricity. It great significance to analyze small signal stability new stations, while traditional eigenvalue analysis method has limitations such as difficulty in selecting independent state variables. In this paper, discrete space applied photovoltaic-battery storage system (PV-BESs) for analysis. The model based on trapezoidal integration rule first constructed, accompanied by its eigenvalues. Then, eigenvalues are...
As cities continuously expand and with the advancement of regional integration, flows people, goods, information have spread beyond their original administrative borders. The top-down borders bottom-up functional divide city regions into areas different attributes hierarchical structures. Although existing studies quantified border effects from perspective spatial interaction, these not clarified differentiated between on activities. Without considering borders, this study first proposed a...
The original EEG data collected are the 1D sequence, which ignores spatial topology information; Feature Pyramid Networks (FPN) is better at small dimension target detection and insufficient feature extraction in scale transformation than CNN. We propose a method of FPN Long Short-Term Memory (FPN-LSTM) for map-based emotion recognition. According to arrangement brain electrodes, Azimuth Equidistant Projection (AEP) employed generate 2D map, preserves then, average power, variance standard...
Background Lung cancer is the leading malignant disease and cause of cancer-related death worldwide. Most patients with lung had insignificant early symptoms so that most them were diagnosed at an advanced stage. In addition to factors such as smoking, pollution, microbiome its metabolites play vital roles in development cancer. However, interaction between microbiota carcinogenesis lack systematically characterized controversial. Therefore, purpose this study was excavate features verify...
The residue of soybean after extraction oils, proteins, and soluble polysaccharides is rich in cellulose but not well utilized. Here, we exploited the as a raw material to isolate nanofibers via robust chemical-mechanical process. (SCNFs) possessed ∼50 nm diameter micrometer-scale length. They high degree crystallinity (75.9%), negative surface charge (-22.5 mV), thermal stability. hydrogel SCNFs represented typical shear-thinning behavior. viscosity was influenced by pH, ionic strength,...
Spectral density matrix estimation of multivariate time series is a classical problem in and signal processing. In modern neuroscience, spectral based metrics are commonly used for analyzing functional connectivity among brain regions. this paper, we develop non-asymptotic theory regularized high-dimensional matrices Gaussian linear processes using thresholded versions averaged periodograms. Our theoretical analysis ensures that consistent $p$-dimensional $n$ samples possible under regime...
Abstract Background Lung cancer (LC) is one of the most devastating diseases worldwide, there growing studies confirm role impaired lung function in LC susceptibility. Moreover, gut microbiota dysbiosis associated with severity. Whether alterations and metabolites are long-term dysfunction patients remain unclear. Our study aimed to analyze risk factors pulmonary based on characteristics microbiome metabolites. Methods Fecal samples from 55 28 benign nodules were collected. Pulmonary...
Fluvial landscapes are a result of lithospheric tectonic movement, climate evolution and surface processes. Existing evidence proves that regional deformation can be reflected by the fluvial landforms. The southern Alashan Block lies closest to northeastern Tibetan Plateau has become latest plateau outward expansion boundary. Yabrai Shan is located at intersection Plateau, Ordos Blocks, thereby recording processes activities in its surrounding regions. Herein, we conducted quantitative...
全球化背景下中国城市历史文脉传承的形势严峻，深入理解中华营城理念的科学内涵、研发既延续历史又面向未来发展的城市设计新路径十分必要。中华营城理念通过空间要素组合关系表达超越形态本身的社会文化意义，这些稳定的空间要素组合关系正是“空间基因”研究的关键性内容。引入空间基因解析与传承技术，可为传承中华营城理念的城市设计提供科学清晰的技术路径。本文还对该技术路径在苏州古城、雄安新区等重大工程中的成功应用进行了介绍，为其它城市的规划建设提供了示范样本。
Genome-wide association studies (GWAS) have identified more than 160 susceptibility loci for colorectal cancer (CRC). The effects of these variants, particularly their mechanisms, however, remain unclear. In this study, a comprehensive functional annotation CRC-related GWAS signals was firstly conducted to identify the potential causal variants. We found that SNP rs7229639 in intron 3 SMAD7 at 18q21.1 might serve as putative variant CRC. is located region with evidence regulatory potential....
Abstract During rapid modernization, the policy of technological upgrading coordinated operation energy supply chain has been tested over many years practice, with limited potential for future development, and further emission reductions are facing greater cost pressures. Market trading policies mainly include carbon emissions mechanism guaranteed renewable power consumption, above will be formally implemented in 2020, which main direction development future. After introducing low-carbon...