A5019100741- Biological Activity of Diterpenoids and Biflavonoids
- Bioactive Natural Diterpenoids Research
- Mitochondrial Function and Pathology
- Neuroscience of respiration and sleep
- Adenosine and Purinergic Signaling
- Medicinal Plant Pharmacodynamics Research
- Free Radicals and Antioxidants
- MicroRNA in disease regulation
- Bioactive Compounds and Antitumor Agents
- Pneumocystis jirovecii pneumonia detection and treatment
- Natural product bioactivities and synthesis
- Peptidase Inhibition and Analysis
- Cardiac Ischemia and Reperfusion
- Intensive Care Unit Cognitive Disorders
- Tuberculosis Research and Epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Neurotoxicity Research
- Plant-based Medicinal Research
- Cardiac, Anesthesia and Surgical Outcomes
- Sleep and Wakefulness Research
- Silk-based biomaterials and applications
- Pneumonia and Respiratory Infections
- Circadian rhythm and melatonin
- Alkaloids: synthesis and pharmacology
- Pharmaceutical and Antibiotic Environmental Impacts
Ningbo Medical Center Lihuili Hospital
2024-2025
Ningbo University
2011-2025
China Academy of Chinese Medical Sciences
2025
Wangjing Hospital of China Academy of Chinese Medical Sciences
2025
Ministry of Agriculture and Rural Affairs
2024
Jiangsu University of Science and Technology
2024
Xinjiang Academy of Agricultural Sciences
2024
Institute of Plant Protection
2024
Sericultural Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
Isodon rubescens has been used as a traditional green tea for more than 1000 years and many medicinal functions of I. are also very useful, such its well-known antitumor antibacterial activities. Oridonin, bioactive ent-kaurane diterpenoid, is the major ingredient this tea. Herein, 22 novel oridonin derivatives were designed synthesized. The activity was evaluated first time. Compound 12 most promising one with MIC 2.0 μg/mL against B. subtilis, which nearly 3-fold stronger positive control...
To develop and assess a nomogram predictive model for evaluating the 28-day mortality risk in patients diagnosed with Pneumocystis who have been admitted to intensive care unit (ICU). From 2008 2022, clinical data on were collected using American Critical Care Medical Information Database IV (MIMIC-IV). Initially, 63 significant indicators included, ICU admission as time node all-cause within 28 days outcome. Using complete modeling, variable selection approach combines two methods: Lasso...
The annual rise in gastrointestinal cancer cases is evident, yet the occurrence of multiple primary malignancies remains comparatively uncommon. In recent years, immunotherapy has swiftly emerged as leading treatment for several solid tumors, including cancers. Single treatments might be ineffective, necessitating need comprehensive integrative medicine. This study reports a case cancers, colorectal and gastric Diverse systemic treatments, like capecitabine, combination capecitabine...
Ecto-5'-nucleotidase (CD73) was overexpressed in malignancies of epithelial origin and involved a variety cellular processes such as cytoprotection anti-inflammation. In the present study, human mammary T-47D cells were transfected with pcDNA-NT5E to establish CD73 cell model. Short small interfering RNA (siRNA) used silence epidermal growth factor receptor (EGFR) gene. Real-time PCR, RT-PCR western-blot study EGFR expression. Surface activity assessed by quantifying conversion etheno-AMP...
Abstract Ischemic postconditioning provides robust neuroprotection, therefore, determining the molecular events may provide promising targets for stroke treatment. Here, we showed that expression of functional mitochondrial voltage-dependent anion channel proteins (VDAC1, VDAC2, and VDAC3) reduced in rat vulnerable hippocampal CA1 subfield after global ischemia. restored VDACs to physiological levels. Stabilized contributed benefits postconditioning. VDAC1 was required maintaining neuronal...
Abstract We report the development of a rapid approach for directly converting indoles into 2‐oxindoles promoted by HOCl formed in situ from combination (bis(trifluoroacetoxy) iodo)benzene (PIFA) and n ‐Bu 4 NCl ⋅ H 2 O. The procedure is widely functional group tolerant provides up to 95% yield within 5 min. potential applications developed methodology are demonstrated gram‐scale preparation 3‐methyl‐2‐oxindole ( 11 ), one‐pot two‐step syntheses spiro‐oxindoles 26 b , formal synthesis...
Resveratrol (Res) was recently reported to ameliorate hypoxia/reoxygenation (H/R)-caused oxidative stress in H9c2 cardiomyocytes through promoting the mitochondrial translocation of DJ-1 protein and subsequently preserving activity complex I. However, it is noteworthy that possesses no mitochondria-targeting sequence. Therefore, how Res induces an important interesting question for further exploration. Glucose-regulated 75 (Grp75), whose N-terminus contains a 51-amino acid long...
Dysregulation of microRNA (miRNA) biogenesis is involved in drug addiction. Argonaute2 (Ago2), a specific splicing protein the generation miRNA, was found to be dysregulated nucleus accumbens (NAc) methamphetamine (METH)-sensitized mice our previous study. Here, we determined whether Ago2 NAc regulates METH sensitization and identified Ago2-dependent miRNAs this process. We gradual reduction expression following repeated use. METH-induced hyperlocomotor activity strengthened by knocking down...
Herein, we reported on a series of synthetic nitric oxide-releasing enmein-type diterpenoid hybrids (9a–i). All the target compounds showed potent antibacterial activity against selected Gram-positive bacteria S. aureus and B. subtilis. The antiproliferative human tumor K562, MGC-803, CaEs-17 Bel-7402 cells, normal liver cells L-02 was tested structure relationships (SARs) were also concluded. Compounds 9b 9d best subtilis with same minimal inhibitory concentrations (MICs) 4 2 μg/mL,...
DJ-1 was recently reported to be involved in the cardioprotection of hypoxic preconditioning (HPC) against hypoxia/reoxygenation (H/R)-induced oxidative stress damage, by preserving mitochondrial complex I activity and, subsequently, inhibiting reactive oxygen species (ROS) generation. However, molecular mechanism which HPC enables translocation DJ-1, has no mitochondria-targeting sequence, preserve I, is largely unknown. In this study, co-immunoprecipitation data showed that associated with...
Abstract Introgression may lead to discordant patterns of variation among loci and traits. For example, previous phylogeographic studies on the genus Quasipaa detected signs genetic introgression from genetically morphologically divergent shini or spinosa . In this study, we used mitochondrial nuclear DNA sequence data verify widespread introgressive hybridization in closely related species , evaluate level diversity, reveal formation mechanism hybridization. Longsheng, Guangxi Province,...
Seven new C-7 acylhydrazone derivatives of dehydroabietic acid were synthesised from through benzylic oxidation, condensation with hydrazine hydrate, followed by nucleophilic substitution reactions a variety substituted aromatic acids. The structures the compounds characterised IR, 1 H NMR and MS. antibacterial activities evaluated disk diffusion method. Antibacterial activity studies showed that exhibited inhibitory against Escherichia coli, Staphylococcus aureus Bacillus subtilis. Among...
Recurrent implantation failure (RIF) is a disease associated with endometrial receptivity dysfunction. Retinoic acid receptor alpha (RARα) an important protein in many biological processes, such as differentiation and development. However, the exact underlying mechanism whereby RARα affects RIF remains unknown. This study investigated expression its contribution mid-luteal phase endometria of patients RIF. The levels CCAAT/enhancer-binding (C/EBP) β normal group were using western blotting...
Abstract Background Cognitive dysfunction, encompassing perioperative psychological distress and cognitive impairment, is a prevalent postoperative complication within the elderly population, in severe cases, it may lead to dementia. Building upon our prior research that unveiled connection between mood fluctuations dysfunction with phosphorylation of P38, this present investigation aims delve deeper into involvement P38 MAPK/NLRP3 pathway neurocognitive disorders (PND) an abdominal...