A5100441008- Viral gastroenteritis research and epidemiology
- Hepatitis Viruses Studies and Epidemiology
- Microbial Natural Products and Biosynthesis
- Herpesvirus Infections and Treatments
- Early Childhood Education and Development
- Virus-based gene therapy research
- Plant and animal studies
- Reproductive Biology and Fertility
- Health disparities and outcomes
- Advanced Radiotherapy Techniques
- Animal Virus Infections Studies
- Insect and Arachnid Ecology and Behavior
- Management of metastatic bone disease
- Reproductive System and Pregnancy
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Tea Polyphenols and Effects
- Phytochemicals and Antioxidant Activities
- Fossil Insects in Amber
- Gut microbiota and health
- Traditional Chinese Medicine Analysis
- Immune Response and Inflammation
- Marine Sponges and Natural Products
- Fungal Biology and Applications
- Plant Water Relations and Carbon Dynamics
Chinese Academy of Agricultural Sciences
2023-2025
Northwest A&F University
2014-2025
Shanghai Veterinary Research Institute
2023-2025
Xi’an University
2023-2025
Institutes of Science and Development
2024-2025
Chinese Academy of Sciences
2019-2025
Xinjiang University
2016-2025
Institute of Forest Ecology, Environment and Protection
2024
Shanghai University of Traditional Chinese Medicine
2016-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2019-2024
Disturbed homeostasis of gut microbiota has been suggested to be closely associated with 5-fluorouracil (5-Fu) induced mucositis. However, current knowledge the overall profiles 5-Fu-disturbed is limited, and so far there no direct convincing evidence proving causality between colonic In mice, in agreement previous reports, 5-Fu resulted severe mucositis indicated by weight loss, diarrhea, bloody stool, shortened colon, infiltration inflammatory cells. It significantly changed...
Asthenozoospermia is a common cause of male infertility, but its etiology remains incompletely understood. We recruited three Pakistani infertile brothers, born to first-cousin parents, displaying idiopathic asthenozoospermia no ciliary-related symptoms. Whole-exome sequencing identified missense variant (c.G5408A, p.C1803Y) in DNAH17, functionally uncharacterized gene, recessively cosegregating with the family. specifically expressed testes, was localized sperm flagella, and mutation did...
The objective of this study was to evaluate the occurrence, spatiotemporal distribution, mass balance and ecological risks 43 commonly used human veterinary antibiotics in both aqueous sedimentary phases a large subtropical shallow lake, Lake Taihu.
Our previous reports suggested that Dietary l-arginine supplementation attenuated gut injury of broiler chickens infected with Clostridium perfringens by enhancing intestinal immune responses, absorption and barrier function, but its effect on the microbiome remains unclear. This experiment aimed at evaluating effects bacterial community composition function challenged C. perfringens. In total, 105 1-day-old male Arbor Acres were assigned to three groups: Control (CTL),...
Four novel compounds, chaephilone C (1), chaetoviridides A-C (2-4), were obtained from the culture of a deep sea derived fungus Chaetomium sp. NA-S01-R1, together with four known compounds-chaetoviridin A (5), chaetoviridine E (6), chaetomugilin D (7) and cochliodone (8). Their structures, including absolute configurations, assigned based on NMR, MS time-dependent density functional theory (TD-DFT) ECD calculations. plausible biogenetic pathway for compounds 1-3 was proposed. Compounds 2 3...
Craniofacial microsomia (CFM) is a congenital defect that usually results from aberrant development of embryonic pharyngeal arches. However, the molecular basis CFM pathogenesis largely unknown. Here, we employ zebrafish model to investigate mechanisms pathogenesis. In early embryos, tet2 and tet3 are essential for cartilage development. Single-cell RNA sequencing reveals loss Tet2/3 impairs chondrocyte differentiation due insufficient BMP signaling. Moreover, biochemical genetic evidence...
Inhibition of microglia activation may provide therapeutic treatment for many neurodegenerative diseases. Astragaloside IV (ASI) with anti-inflammatory properties has been tested as a drug in clinical trials China. However, the mechanism ASI inhibiting neuroinflammation is unknown. In this study, we showed that inhibited both vivo and vitro. It could enhance glucocorticoid receptor (GR)-luciferase activity facilitate GR nuclear translocation microglial cells. Molecular docking TR-FRET...
Clostridium perfringens is the causative pathogen of avian necrotic enteritis. Lactobacillus spp. are well-characterized probiotics with anti-microbial and immune-modulatory activities. In present study, we investigated effects L. acidophilus fermentum on growth, α-toxin production inflammatory responses C. perfringens. in vitro culture experiments, both lactobacilli inhibited growth (P < 0.01), accompanied a decrease pH 0.01). Supernatants from cultures also suppressed during 24 h...
Abstract Multiple morphological abnormalities of the flagella (MMAF) is a genetically heterogeneous disorder leading to male infertility. Recent studies have revealed that DNAH17 variants are associated with MMAF, yet there no functional evidence in support their pathnogenicity. Here, we recruited two consanguineous families Pakistani and Chinese origins, respectively, diagnosed MMAF. Whole‐exome sequencing identified novel homozygous variants, which led loss proteins, patients. Transmission...
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease characterized by synovial inflammation and joint bone cartilage destruction. Curcumin can improve in rats with inhibit revascularization abnormal proliferation of fibroblasts. However, it unclear whether curcumin affects the RA progression. The TNF-α-stimulated primary fibroblast-like synoviocytes (RA-FLS) SV-40 transformed MH7A cells were used as vitro model RA. A mouse collagen-induced (CIA) was vivo model. effects on cell...
The inappropriate use of antibiotics has led to the emergence multidrug-resistant strains. Bacteriophages (phages) have gained renewed attention as promising alternatives or supplements antibiotics. In this study, a lytic avian pathogenic Escherichia coli (APEC) phage designated PEC9 was isolated and purified from chicken farm feces samples. morphology, genomic information, optimal multiplicity infection (MOI), one-step growth curve, thermal stability, pH in vitro antibacterial ability...
Although spine stereotactic body radiation therapy (SBRT) is considered a standard of care in the mobile spine, mature evidence reporting outcomes specific to sacral metastases lacking. Furthermore, there need validate existing SBRT international consensus contouring guidelines define optimal approach. We report rates local failure (LF), adverse events, and effect deviations largest experience date sacrum SBRT.
Abstract Background Tamdy virus (TAMV) was first isolated in Uzbekistan and Turkmenistan. In 2018, it found China, marking its entry into the molecular research era. TAMV is linked to febrile diseases, but epidemiology spillover risks are poorly understood, necessitating urgent detection method development. Methods The secondary structure of glycoprotein Gn predicted, results showed that had rich antigenic epitopes. According predicted results, divided 46 truncated 16-peptides by modified...
The widespread chronic enteritis known as Paratuberculosis (PTB) or Johne's disease (JD) is caused by Mycobacterium avium subspecies paratuberculosis (MAP), posing a significant threat to global public health. Given the challenges associated with PTB JD, development and application of vaccines are potentially important for control. aim this study was design multi-epitope vaccine against MAP. A total 198 MAP genomes were analyzed using pan-genome reverse vaccinology approaches. B-cell T-cell...