A5084090451- Trauma and Emergency Care Studies
- Spinal Fractures and Fixation Techniques
- Spinal Cord Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Emergency and Acute Care Studies
- Cardiac Arrest and Resuscitation
- Trauma Management and Diagnosis
- Neurosurgical Procedures and Complications
- Autopsy Techniques and Outcomes
- Management of metastatic bone disease
- Neuroscience and Neuropharmacology Research
- Advanced Memory and Neural Computing
- Neural dynamics and brain function
- Vascular Malformations Diagnosis and Treatment
- Global Health Care Issues
- Intracerebral and Subarachnoid Hemorrhage Research
- Artificial Intelligence in Healthcare and Education
- Trigeminal Neuralgia and Treatments
- Health disparities and outcomes
- Intracranial Aneurysms: Treatment and Complications
- Medical Imaging and Analysis
- Meningioma and schwannoma management
University of Toronto
2020-2025
St. Michael's Hospital
2023-2025
Dow University of Health Sciences
2025
Unity Health Toronto
2023-2024
Toronto Public Health
2024
St Michaels Hospital
2023
Institute for Work & Health
2023
Hospital for Sick Children
2020-2023
Systems, Applications & Products in Data Processing (Canada)
2023
Primary Source
2023
Abstract Background Spinal metastases are a significant complication of advanced cancer. In this study, we assess temporal trends in the incidence and timing spinal examine underlying patient demographics primary cancer associations. Methods population-based retrospective cohort health data from 2007 to 2019 Ontario, Canada were analyzed (n = 37, 375 patients identified with spine metastases). Primary outcomes annual metastasis, time metastasis after diagnosis. Results The age-standardized...
Neurons regulate their excitability by adjusting ion channel levels. Degeneracy – achieving equivalent outcomes (excitability) using different solutions (channel combinations) facilitates this regulation enabling a disruptive change in one to be offset compensatory changes other channels. But neurons must coregulate many properties. Pleiotropy the impact of on more than property complicates because that restores its target value often disrupts How then does neuron simultaneously multiple...
Although spine stereotactic body radiation therapy (SBRT) is considered a standard of care in the mobile spine, mature evidence reporting outcomes specific to sacral metastases lacking. Furthermore, there need validate existing SBRT international consensus contouring guidelines define optimal approach. We report rates local failure (LF), adverse events, and effect deviations largest experience date sacrum SBRT.
BACKGROUND AND OBJECTIVES: Tracheostomy is crucial for managing airway and respiratory complications in spinal cord injury (SCI) patients, with recent studies linking its timing to outcomes. The aim of this study was determine the association between adverse events tracheostomy complete traumatic cervical SCI patients. METHODS: This multicenter retrospective observational cohort used data from Trauma Quality Improvement Program 2010 2020 included all patients who underwent spine surgery...
Purpose To develop an automated triage tool to predict neurosurgical intervention for patients with traumatic brain injury (TBI). Materials and Methods A provincial trauma registry was reviewed retrospectively identify TBI from 2005 2022 treated at a specialized Canadian center. Model training, validation, testing were performed using head CT scans binary reference standard patient-level labels corresponding whether the patient received intervention. Performance accuracy of model, Automated...
There is conflicting evidence regarding the relationship between trauma center type and mortality for children with traumatic brain injuries. Identification of differences following injury across differing types may result in actionable quality improvement initiatives to standardize care these children.
Abstract Frailty, as measured by the modified frailty index-5 (mFI-5), and older age are associated with increased mortality in setting of spinal cord injury (SCI). However, there is limited evidence demonstrating an incremental prognostic value derived from patient mFI-5. We conducted a retrospective cohort study to evaluate in-hospital among adult complete cervical SCI patients at participating centers Trauma Quality Improvement Program 2010 2018. Logistic regression was used model...
Withdrawal of life-sustaining treatment (WLST) in severe traumatic brain injury (TBI) is complex, with a paucity standardized guidelines. We aimed to assess the variability WLST practices between trauma centers North America.
Traumatic spinal cord injury (SCI) leads to profound neurologic sequelae, and the provision of life-supporting treatment serves great importance among this patient population. The decision for withdrawal (WLST) in complete traumatic SCI is complex with lack guidelines limited understanding practice patterns. We aimed evaluate individual contextual factors associated WLST assess between-center differences patterns across North American trauma centers patients cervical SCI.This retrospective...
BACKGROUND AND OBJECTIVES: Recent evidence suggests earlier tracheostomy is associated with fewer complications in patients complete cervical spinal cord injury (SCI). This study aims to evaluate the influence of spine surgical approach on association between timing and in-hospital adverse events treating SCI. METHODS: retrospective cohort was performed using Trauma Quality Improvement Program data from 2017 2020. All acute (American Spinal Injury Association-A) SCI who underwent surgery...
INTRODUCTION: Artificial intelligence (AI) model integration into clinical workflow offers potential to optimize decision-support for transfer of acute traumatic brain injury (TBI) patients appropriate trauma centers. METHODS: We retrospectively identified TBI from 2005-2021 treated at a quaternary Canadian center. employed various modeling techniques including principal component analysis, three-dimensional convolutional neural networks, and transformer-based approach using Vision...
INTRODUCTION: The decision to withdraw life sustaining treatment (WLST) for pediatric patients with severe traumatic brain injury (TBI) is challenging clinicians and families limited evidence quantifying existing practices. METHODS: This retrospective study utilized data collected from trauma centers through the American College of Surgeons Trauma Quality Improvement Program between 2017-2020. We included (<19 years) TBI a documented WLST. random intercept multilevel logistic regression...