A5079012174- Advanced Radiotherapy Techniques
- Management of metastatic bone disease
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Spine and Intervertebral Disc Pathology
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Spinal Fractures and Fixation Techniques
- Radiation Therapy and Dosimetry
- Radiopharmaceutical Chemistry and Applications
- Meningioma and schwannoma management
- Medical Imaging and Analysis
- Lanthanide and Transition Metal Complexes
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Urinary Bladder and Prostate Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Electron Spin Resonance Studies
- Advanced X-ray and CT Imaging
Health Sciences Centre
2016-2025
Sunnybrook Health Science Centre
2016-2025
University of Toronto
2015-2024
St. Michael's Hospital
2017-2024
Sunnybrook Research Institute
2024
Wolters Kluwer (Netherlands)
2023
University Health Network
2018-2021
Princess Margaret Cancer Centre
2012-2021
Creative Commons
2016-2021
Thomas Jefferson University
2021
Study Design: A broad narrative review. Objectives: The objective of this article is to provide a technical review spine stereotactic body radiotherapy (SBRT) planning and delivery, indications for treatment, outcomes, complications, the challenges response assessment. surgical approach spinal metastases discussed with an overview emerging minimally invasive techniques. Methods: comprehensive literature was conducted on techniques, developments in SBRT surgery metastases. Results: optimal...
We report mature outcomes for a cohort of patients with no prior radiation (de novo) to the spine treated 24 Gy in 2 daily fractions metastases, which represents same stereotactic body therapy (SBRT) regimen under evaluation current Symptom Control-24 phase 3 randomized trial (NCT02512965).The consisted 279 de novo spinal metastases 145 consecutive SBRT fractions, identified from prospective single-institution database. The endpoints were overall survival (OS), imaging-based local failure...
Abstract About 20–40% of cancer patients develop brain metastases, causing significant morbidity and mortality. Stereotactic radiation treatment is an established option that delivers high dose to the target while sparing surrounding normal tissue. However, up 20% metastatic tumours progress despite stereotactic treatment, it can take months before evident on follow-up imaging. An early predictor therapy outcome in terms tumour local failure (LF) crucial, facilitate adjustments or allow for...
Brain metastases are a common complication of renal cell carcinoma (RCC). Our group previously published the Renal Graded Prognostic Assessment (GPA) tool. In our prior RCC study (n = 286, 1985-2005), we found marked heterogeneity and variation in outcomes. recent update larger, more contemporary cohort, identified additional significant prognostic factors. The purpose this is to original Renal-GPA based on newly factors.A multi-institutional retrospective institutional review board-approved...
Neutrophil to lymphocyte ratio (NLR) is an easy measurable laboratory marker used evaluate systemic inflammation. Elevated NLR associated with poor survival and increased morbidity in cancer cardiovascular disease. However, the usefulness of predict mortality a hospital setting for patients multiple chronic conditions has not been previously examined. In this study, we investigate association between multimorbid medical inpatients. Two hundred thirty in-patients were selected from single...
Abstract Background The objective was to evaluate the risk and predictors of developing leptomeningeal disease (LMD) in patients with brain metastases treated 5-fraction hypofractionated stereotactic radiotherapy (HSRT). Methods Patients HSRT for intact and/or surgical cavities were reviewed from a prospectively maintained database. Radiographic patterns LMD classified as focal classical, diffuse nodular, nodular. Results delivered, most commonly 30 Gy 5 fractions, 320 intracranial lesions...
Although spine stereotactic body radiation therapy (SBRT) is considered a standard of care in the mobile spine, mature evidence reporting outcomes specific to sacral metastases lacking. Furthermore, there need validate existing SBRT international consensus contouring guidelines define optimal approach. We report rates local failure (LF), adverse events, and effect deviations largest experience date sacrum SBRT.