A5083992891- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Management of metastatic bone disease
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Molecular Biology Techniques and Applications
- Sarcoma Diagnosis and Treatment
- RNA modifications and cancer
- Meningioma and schwannoma management
- Ocular Oncology and Treatments
- Radiation Therapy and Dosimetry
- Vascular Tumors and Angiosarcomas
- Breast Cancer Treatment Studies
- Bone Tumor Diagnosis and Treatments
- Cancer Genomics and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Treatments and Mutations
- Glioma Diagnosis and Treatment
- Voice and Speech Disorders
- BRCA gene mutations in cancer
University of Florida
2016-2025
Florida College
2016-2025
University of Florida Health
2013-2023
Jacksonville University
2020
Jacksonville College
2015-2019
Mayo Clinic in Florida
2015-2019
University of North Florida
2016-2019
WinnMed
2015-2019
University of Florida Health Science Center
2014
UF Health Cancer Center
2012
PURPOSE Plasma circulating tumor human papillomavirus DNA (ctHPVDNA) is a sensitive and specific biomarker of (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC). We investigated whether longitudinal monitoring ctHPVDNA during post-treatment surveillance could accurately detect clinical disease recurrence. METHODS AND MATERIALS A prospective trial was conducted among patients with nonmetastatic HPV-associated (p16-positive) OPSCC. All were treated curative-intent chemoradiotherapy...
To identify a profile of circulating tumor human papilloma virus (HPV) DNA (ctHPVDNA) clearance kinetics that is associated with disease control after chemoradiotherapy (CRT) for HPV-associated oropharyngeal squamous cell carcinoma (OPSCC).A multi-institutional prospective biomarker trial was conducted in 103 patients (i) p16-positive OPSCC, (ii) M0 disease, and (iii) receipt definitive CRT. Blood specimens were collected at baseline, weekly during CRT, follow-up visits. Optimized...
Abstract BACKGROUND: Marginal excision of soft tissue sarcoma (STS), defined as resection through the tumor pseudocapsule or surrounding reactive tissue, increases likelihood local recurrence and necessitates re‐excision postoperative radiation. However, its impact after preoperative radiation therapy (RT) remains unclear. This study therefore investigated significance marginal margins in patients treated with RT for extremity STS, reporting long‐term control limb preservation endpoints....
<h3>Importance</h3> The outcomes and factors that influence survival in patients with oligometastasis (OM) are not well understood have been described large-scale studies. <h3>Objective</h3> To evaluate overall progression-free (PFS), widespread progression (WSP) outcomes, from a pooled data set of 1033 OM treated stereotactic body radiotherapy (SBRT). <h3>Design, Setting, Participants</h3> Case series January 1, 2008, to December 31, 2016. dates analysis were April 2019 May 2020. setting...
PIK3CA is the most frequently mutated gene in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC). Prognostic implications of such mutations remain unknown. We sought to elucidate clinical significance HPV-associated OPSCC patients treated with definitive chemoradiation (CRT). Seventy-seven were enrolled on two phase II trials deintensified CRT (60 Gy intensity-modulated radiotherapy concurrent weekly cisplatin). Targeted next-generation sequencing was...
Objective: To evaluate the role of postoperative radiotherapy (RT) for patients with dermatofibrosarcoma protuberans (DFSP). Methods and Materials: Ten were treated surgery RT had follow-up from 21 to 185 months. Nine DFSP 1 patient a fibrosarcomatous component (DFSP-FS). No gross disease at time RT. Results: remained free after The DFSP-FS experienced local recurrence surgery, external beam RT, brachytherapy boost, died disease. There no severe complications. Conclusion: Postoperative may...
We analyzed outcomes after stereotactic ablative body radiotherapy for oligometastatic (1-5 metastatic foci) head-and-neck squamous cell carcinoma (OM-HNSCC).We reviewed patients treated between 2012 and 2016. Endpoints included overall survival (OS), distant progression, treated-metastasis local control (TM-LC).We 27 with 60 primarily metachronous metastases (81.5%). Median follow-up was 1.6 years (0.2-5.2). time from diagnosis to treatment 1.1 (0.08-8.5). Overall, 44.4% had solitary, 2-3,...
Dermatofibrosarcoma protuberans (DFSP) is a rare indolent cutaneous tumor. In this analysis, we assess the effectiveness of postoperative radiotherapy (RT) in treating patients with DFSP.From 1983 to 2011, 14 DFSP were treated RT at our institution. One patient had gross disease time as he did not have prior resection. The remaining 13 surgery and RT. Two fibrosarcomatous component (DFSP-FS). External-beam was administered continuous course doses ranging from 55.8 66.0 Gy.Follow-up ranged...
Objective The objective of this study was to report the outcomes on a preliminary cohort patients with tumor encasement either, or both, cervical internal carotid artery (ICA) and common (CCA) following preoperative covered stent placement surgical resection. Setting This set at University Florida College Medicine, Jacksonville, FL. Participants Subjects who received stenting ICA/CCA before resection head neck tumors between April 1, 2015, July 31, 2015 were participated. Main Outcome...
ABSTRACT Background In contrast to adult salivary gland tumors, our institutional guidelines utilize lower radiation doses, smaller target margins, and proton therapy (PT) minimize children's developing skull base anatomy. Herein, we report outcomes of pediatric management approach. Procedures We identified 31 patients with tumors treated PT at institution between 2006 2023. Most common histologies were mucoepidermoid carcinoma ( n = 14), acinic cell 5), adenoid cystic 5). Eight radiographic...
To define the role of elective neck dissection during salvage surgery for locally recurrent head and squamous cell carcinoma (SCCA) initially treated with nodal irradiation (ENI).Retrospective chart review.We reviewed medical records patients ENI at our institution from 1965 to 2006 T1-4 N0 M0 SCCA oropharynx, hypopharynx, or larynx who developed an isolated local recurrence remained N0. Fifty-seven were salvaged, 40 17 observation. We then compared toxicity actuarial outcomes between two...
Adenoid cystic carcinoma (ACC) is rare malignancy accounting for 1% of all head and neck cancers. Treatment ACC has its challenges risks, yet few outcomes studies exist. We present long-term patients with the treated proton therapy (PT). Under an IRB-approved, single-institutional prospective registry, we reviewed records 56 de novo, nonmetastatic PT definitive (n = 9) or adjuvant 47) from June 2007 – December 2021. The median dose to primary site was 72.6 GyRBE (range, 64 74.4) delivered as...
To analyze the outcomes of patients treated for solitary plasmacytoma with definitive radiotherapy (RT).Thirty-two bone (SPB; 22 patients) and extramedullary (EMP; 10 were between 1963 2006. The median RT dose was around 42.7 Gy (range, 15-54 Gy) over a 25 fractions 1-32 fractions). No patient received adjuvant chemotherapy. Median follow-up 10.1 years 1-33 years). on living 7.3 2.1-33 years).The 10-year local-control rate after 87%. All 4 who developed local recurrence had SPBs > or = 5 cm....
Aims Stereotactic body radiotherapy (SBRT) for oligometastases is increasingly used with few evidenced-based guidelines. We conducted a survey to determine patient selection and follow-up practice patterns.Materials methods Seven institutions from US, Canada, Europe, Australia that recommend SBRT participated in 72-item survey. Levels of agreement were categorized as strong (6–7 common responses), moderate (4–5), low (2–3), or no agreement.Results There was recommending eradication all...