A5021553632- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Radiation Therapy and Dosimetry
- Prostate Cancer Treatment and Research
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Prostate Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Pancreatic and Hepatic Oncology Research
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Breast Cancer Treatment Studies
- Esophageal Cancer Research and Treatment
- Colorectal and Anal Carcinomas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Head and Neck Surgical Oncology
- Global Cancer Incidence and Screening
- Renal cell carcinoma treatment
University of Maryland, Baltimore
2016-2025
University of Maryland Medical System
2017-2025
University of Maryland Medical Center
2015-2024
Sidney Kimmel Comprehensive Cancer Center
2024
Johns Hopkins University
2024
Kosin University Gospel Hospital
2024
Thomas Jefferson University
2024
Ghent University
2024
University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
2023
University of Virginia
2022
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary point, may be published when key planned co‐primary or secondary analyses are not yet available. Trial Updates provide an opportunity to disseminate additional results from studies, in JCO elsewhere, for which point has already been reported. STOMP and ORIOLE trial reports suggested metastasis-directed therapy (MDT) oligometastatic castration-sensitive...
The hemopoietic-specific Rho family GTPase Rac2 shares 92% amino acid identity with ubiquitously expressed Rac1. Neutrophils from rac2(-/-) mice have multiple defects, including chemoattractant-stimulated NADPH oxidase activity and chemotaxis, which may result an overall reduction in cellular Rac or mechanisms that discriminate Rac1 Rac2. We show murine neutrophils similar amounts of Rac2, unlike human neutrophils, express predominantly An affinity precipitation assay for Rac-GTP showed...
Glucocorticoid hormones, including dexamethasone, induce apoptosis in lymphocytes and consequently are used clinically as chemotherapeutic agents many hematologic malignancies. Dexamethasone also induces autophagy lymphocytes, although the mechanism is not fully elucidated. Through gene expression analysis, we found that dexamethasone of a encoding stress response protein variously referred to Dig2, RTP801, or REDD1. This reported inhibit mammalian target rapamycin (mTOR) signaling. Because...
Synthetic glucocorticoids were one of the first effective treatments for lymphoid malignancies because their ability to induce apoptosis and are still used in combination with other chemotherapeutic agents. Up-regulation Bim, a proapoptotic member B-cell lymphoma-2 family, is an important mediator glucocorticoid-induced apoptosis. Although known elevate Bim mRNA protein, little about mechanism. Here, we report that repress expression microRNA cluster miR-17∼92, which results elevated protein...
T cell receptor activation induces inositol 1,4,5 trisphosphate (IP(3))-mediated calcium signaling that is essential for metabolism and survival. Moreover, inhibitors of IP(3) or pharmacological agents disrupt homeostasis readily induce autophagy. Using a glucocorticoid-sensitive CD4/CD8 positive line, we found dexamethasone prevented both IP(3)-mediated spontaneous signals within timeframe correlated with the induction We determined this loss in was dependent upon downregulation Src kinase...
Brain metastases are a common complication of renal cell carcinoma (RCC). Our group previously published the Renal Graded Prognostic Assessment (GPA) tool. In our prior RCC study (n = 286, 1985-2005), we found marked heterogeneity and variation in outcomes. recent update larger, more contemporary cohort, identified additional significant prognostic factors. The purpose this is to original Renal-GPA based on newly factors.A multi-institutional retrospective institutional review board-approved...
Abstract This study addresses the limited non-invasive tools for Oral Cavity Squamous Cell Carcinoma (OSCC) survival prediction by identifying Computed Tomography (CT)-based biomarkers to improve prognosis prediction. A retrospective analysis was conducted on data from 149 OSCC patients, including CT radiomics and clinical information. An ensemble approach involving correlation analysis, score screening, Sparse-L1 algorithm used select functional features, which were then build Cox...
Re-irradiation (re-RT) for recurrent head and neck cancer (rHNC) is challenging. We describe clinical outcomes toxicity of proton therapy (PT) HNC, report genomic alterations associated with patterns failure. performed a retrospective analysis rHNC patients treated PT. Outcomes were estimated using the Kaplan-Meier method. Univariate (UVA) multivariate analyses (MVA) to assess multiple patient factors. Next-generation sequencing on available samples. Eighty-nine PBS-PT median follow-up 12 mo...
This study addresses the limited noninvasive tools for Head and Neck Squamous Cell Carcinoma (HNSCC) progression-free survival (PFS) prediction by identifying Computed Tomography (CT)-based biomarkers predicting prognosis. A retrospective analysis was conducted on data from 203 HNSCC patients. An ensemble feature selection involving correlation analysis, univariate best-subset selection, LASSO-Cox algorithm used to select functional features, which were then build final Cox Proportional...
Advances in the treatment of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) include transoral robotic surgery (TORS) and proton beam therapy (PBT). This study aims to improve understanding toxicities associated with adjuvant PBT following TORS for OPSCC. A retrospective review. An academic tertiary care center Baltimore, Maryland. Patients undergoing followed by from 2017 2023 were reviewed. Forty-seven patients HPV-associated OPSCC underwent PBT....
TPS283 Background: Some patients with oligometastases may have the potential for long-term disease-free survival just aggressive local therapy as shown by randomized trials total consolidation of macroscopic metastases using metastasis-directed (MDT). Long-term outcomes pooled STOMP and ORIOLE in oligorecurrent metastatic castration-sensitive prostate cancer (omCSPC) demonstrated MDT improved progression free survival. However, men high-risk mutations, including pathogenic alterations ATM ,...
Abstract Introduction Clinical trial data comparing outcomes after administration of stereotactic radiosurgery (SRS) or whole‐brain radiotherapy (WBRT) to patients with brain metastases (BM) suggest that SRS better preserves cognitive function and quality life without negatively impacting overall survival. Here, we estimate the maximum number BM can be treated using single multi‐session while limiting dose radiation delivered normal tissue associated WBRT. Methods Multiple‐tumor was...