A5087431512- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Immunotherapy and Immune Responses
- Salivary Gland Tumors Diagnosis and Treatment
- Infant Nutrition and Health
- Sinusitis and nasal conditions
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Esophageal and GI Pathology
- Lung Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Oral and Maxillofacial Pathology
- Patient-Provider Communication in Healthcare
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Cardiac tumors and thrombi
- Ear and Head Tumors
- HIV Research and Treatment
- Bone Tumor Diagnosis and Treatments
- Voice and Speech Disorders
- Traumatic Ocular and Foreign Body Injuries
- COVID-19 and healthcare impacts
- Tumors and Oncological Cases
- Nonmelanoma Skin Cancer Studies
University of Maryland, Baltimore
2011-2024
Technical University of Munich
2024
University of Mary
2022
UCSF Helen Diller Family Comprehensive Cancer Center
2021
University of California, San Francisco
2021
Heat Biologics (United States)
2021
American Academy of Otolaryngology — Head and Neck Surgery
2021
University of Maryland Medical Center
2010-2020
Cancer Research And Biostatistics
2020
Gdańsk Medical University
2017
We previously reported that human head and neck squamous cell carcinomas (HNSCCs) express the pro-inflammatory pro-angiogenic cytokines interleukin (IL)-1α, IL-6, IL-8, granulocyte-macrophage colony-stimulating factor in vitro vivo. The promoter region of genes encoding these include binding sites for transcription factors nuclear (NF) κB/Rel A, activator protein-1 (AP-1), CCAAT enhancer-binding protein β (C/EBPβ, or NF-IL6), which have been to contribute activation cytokine genes. In study...
B-cell maturation antigen-targeted chimeric antigen receptor T-cell therapy (BCMA CAR-T) is an effective treatment of relapsed refractory multiple myeloma (MM). However, the pattern infectious complications not well elucidated. We performed a single-center retrospective analysis infection outcomes up to 1 year after BCMA CAR-T for MM from 2018 2020. Fifty-five patients with were treated CAR-T. Before lymphodepletion (LD), 35% had severe hypogammaglobulinemia and 18% lymphopenia. Most (68%)...
Abstract In this work, we investigated the anticancer activity of orally administered recombinant human lactoferrin (rhLF) alone and in combination with chemotherapy tumor‐bearing mice. rhLF inhibited growth squamous cell carcinoma (O12) tumors T cell–immunocompromised nu/nu mice by 80% when at 1,000 mg/kg (2.9 g/m 2 ) oral gavage twice daily for 8 days ( p < 0.001). Similar was observed syngeneic, immunocompetent BALB/c mice, where (1,000 mg/kg, 2.9 once daily) halted mammary...
Abstract Purpose: Human lactoferrin is a naturally occurring glycoprotein that inhibits cancer growth. Our purpose was to evaluate recombinant human as chemotherapeutic agent against head and neck squamous cell carcinoma. Experimental Design: Controlled experiments both in vitro the murine model evaluating effect mechanism of on Results: In lines, induced dose-dependent growth inhibition. Using flow cytometric analysis, shown induce G1-G0 arrest. This arrest seemed be modulated by...
Circulating plasmacytoid dendritic cells (pDC) decline during HIV-1 infection, but at the same time they express markedly higher levels of interferon alpha (IFNα), which is associated with disease progression. Here we show an accumulation pDC in lymph nodes (LN) treatment-naïve patients. This phenomenon was elevated expression LN homing marker, CCR7, on peripheral blood patients, conferred increased migratory capacity response to CCR7 ligands ex vivo functional assays. LN-homed patients...
Abstract Background This study analyzed the impact of timing percutaneous endoscopic gastrostomy (PEG) tube placement on clinical endpoints in patients undergoing concurrent chemoradiation therapy (CRT). Methods In all, 111 who underwent CRT for locally advanced squamous cell carcinoma head and neck (SCCHN) were retrospectively to determine effect PEG weight loss, hospitalizations, rates complications/dependence. Results Early was correlated reductions loss during ( p < .001, R = 0.495),...
Abstract Background We performed a pilot study using Trojan vaccines in patients with advanced squamous cell carcinoma of the head and neck (SCCHN). These are composed HLA‐I HLA‐II restricted melanoma antigen E (MAGE)‐A3 or human papillomavirus (HPV)‐16 derived peptides, joined by furin‐cleavable linkers, linked to “penetrin” peptide sequence from HIV‐TAT. Thirty‐one SCCHN were screened for trial 5 enrolled. Methods Enrolled treated 300 μg supplemented Montanide granulocyte‐macrophage...
Re-irradiation (re-RT) for recurrent head and neck cancer (rHNC) is challenging. We describe clinical outcomes toxicity of proton therapy (PT) HNC, report genomic alterations associated with patterns failure. performed a retrospective analysis rHNC patients treated PT. Outcomes were estimated using the Kaplan-Meier method. Univariate (UVA) multivariate analyses (MVA) to assess multiple patient factors. Next-generation sequencing on available samples. Eighty-nine PBS-PT median follow-up 12 mo...
Abstract Objective : Benign paroxysmal positional vertigo (BPFV) is a common condition seen by otolaryngologists. The purpose of this study to determine the ability modified Epley maneuver treat BPPV. Study Design Retrospective review. Methods A retrospective chart review 107 patients diagnosed with BPPV at our institution between March 1993 and June 1995. Each patient was isolated history Hallpike‐Dix maneuver. There were no other vestibular symptoms or electronystagmogram abnormalities....
Racial outcome disparities have been observed in head and neck squamous cell carcinoma (HNSCC) with diminished survival for black patients compared white patients.We retrospectively analyzed 1318 primary HNSCC treated at the University of Maryland Greenebaum Cancer Center (UMGCC) from 2000 to 2010.Of all patients, 65.9% were white, 30.7% black, 3.3% other races. Black less likely present oral cavity cancer, more laryngeal or hypopharyngeal cancers. White early stage disease, especially...
A questionnaire was sent to members of the American Society Colon and Rectal Surgeons. Four hundred forty-five (43.6%) were tabulated establish criteria results surgical treatment hemorrhoidal disease. The most frequent indication for surgery, internal external hemorrhoids with mucosal prolapse. Significant differences found in time required complete healing, frequency wound dehiscence, postoperative stenosis, infection. Results did not support opinions that closed technique associated...
The Type I Posterior Glottic Stenosis (PGS-I) is a well-described but uncommon clinical entity. Despite this, there little known about the outcome of surgical treatment.Retrospective case series.Thirteen cases met inclusion criteria. All one patient had tracheostomy at time initial evaluation. At postoperative visit, seven patients (54%) completely normal vocal fold motion. Of verbal patients, 6 (50%) function as reported by both patient/caregiver and physician, 10 (83%) were successfully...
To understand patient expectations during the informed consent process for functional endoscopic sinus surgery (FESS).Multi-institutional, cross-sectional survey design.Anonymous surveys were administered to patients in two tertiary academic centers with a chief complaint relating "allergy and sinus" problems. Patients completed an eight-item questionnaire that assessed both nature level of risks they wished be prior FESS.Three hundred eighty-nine returned. Sixty-nine percent complications...
Lactoferrin, a naturally occurring glycoprotein found in breast milk, has previously been shown to have antimicrobial properties and recently demonstrated inhibit malignant tumor growth, presumably through immunomodulation. We hypothesized that intratumoral injection of human murine recombinant lactoferrin would decrease the growth tumors vivo. Using an orthotopic model for both squamous cell carcinoma fibrosarcoma floor mouth, we administered directly into using variable dosing strategies....
Functional endoscopic sinus surgery (FESS) is one of the more common procedures performed by otolaryngologists. Before performing FESS, surgeons are obligated to discuss procedure and its risks through process informed patient consent. The study identifies current practices in consent for FESS formulates guidelines FESS.Survey.Surveys were sent 1000 American Academy Otolaryngology-Head Neck Surgery members United States. Surveys inquired about related FESS.Three hundred forty-six surveys...