A5019128623- Brain Metastases and Treatment
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Management of metastatic bone disease
- Breast Cancer Treatment Studies
- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Radiation Therapy and Dosimetry
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Head and Neck Cancer Studies
- Breast Lesions and Carcinomas
- PI3K/AKT/mTOR signaling in cancer
- Lymphoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Spine and Intervertebral Disc Pathology
- Gastric Cancer Management and Outcomes
- Renal cell carcinoma treatment
- Bone Tumor Diagnosis and Treatments
- Lung Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- Melanoma and MAPK Pathways
- Nonmelanoma Skin Cancer Studies
- Colorectal and Anal Carcinomas
Vanderbilt University Medical Center
2022-2025
Vanderbilt University
2024
Vanderbilt-Ingram Cancer Center
2024
Florida College
2019-2021
University of Florida
2019-2021
Radiation Oncology Associates
2017-2020
Memorial Sloan Kettering Cancer Center
2015-2019
University of Florida Health
2018
UF Health Cancer Center
2018
Sichuan University
2017
Purpose Stereotactic radiosurgery (SRS), whole-brain radiotherapy (WBRT), and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are treatment options for brain metastases in patients with EGFR-mutant non-small-cell lung cancer (NSCLC). This multi-institutional analysis sought to determine the optimal management of NSCLC who develop have not received EGFR-TKI. Materials Methods A total 351 from six institutions developed met inclusion criteria study. Exclusion included...
3 Background: The incidence of anal cancer has recently exceeded > 10,000 patients/year in the United States. For non-metastatic squamous cell carcinoma canal (SCCA), concurrent chemoradiotherapy (CRT) followed by abdominoperineal resection (APR) as salvage surgery for non-responders is a key treatment approach. Over past two decades, findings from phase III trials (RTOG 98-11 and ACT II) have increased our knowledge about appropriate approaches. II indicated that delayed assessment tumor...
Brain metastases are a common complication of renal cell carcinoma (RCC). Our group previously published the Renal Graded Prognostic Assessment (GPA) tool. In our prior RCC study (n = 286, 1985-2005), we found marked heterogeneity and variation in outcomes. recent update larger, more contemporary cohort, identified additional significant prognostic factors. The purpose this is to original Renal-GPA based on newly factors.A multi-institutional retrospective institutional review board-approved...
To examine the late effects of intensity-modulated radiation therapy (IMRT) in pediatric patients with rhabdomyosarcoma head and neck.All 1-year survivors neck treated IMRT at a single institution from 1999 to 2014 were assessed for long-term complications. Late toxicities graded according CTCAE version 4.03.Among 30 patients, median age was 7.4 (1.5-20.8) years, follow-up 7.7 (1.2-14.4) dose 50.4 (36-50.4) Gy. Tumor subsites included parameningeal (80%), orbit (13%), other (7%). Common...
ABSTRACT Background Time from surgery to initiation of postoperative radiation therapy (PORT) less than 6 weeks was recently instituted as the first quality metric within head and neck cancer care. Methods We performed a retrospective single institution cohort study investigate predictors PORT delay impact on survival. Results rate 73.2%, with median time treatment 51 days. Outside facility independently associated increased likelihood (OR 1.94, 95% CI 1.03–3.74, p = 0.043). location did not...
OBJECTIVE Chordoma is a rare malignant tumor for which en bloc resection with wide margins advocated as primary treatment. Unfortunately, due to anatomical constraints, achieve or marginal not feasible many patients the resulting morbidity would be prohibitive. The objective of this study was evaluate efficacy intralesional curettage and separation surgery followed by spinal stereotactic body radiation therapy (SBRT) in chordomas mobile spine. METHODS authors performed retrospective chart...
To develop a geometric atlas that can predict tumor shrinkage and guide treatment planning for non-small-cell lung cancer. evaluate the impact of on ability dose escalation.
ObjectivesHyperactivation of the phosphatidylinositol-3-kinase (PI3K) pathway has been associated with radioresistance. It is unclear whether such mutations confer suboptimal local control for patients who receive lung stereotactic body radiation therapy (SBRT). Our objective was to examine in EGFR/AKT/PIK3CA signaling are failure (LF) after SBRT.MethodsWe retrospectively reviewed 166 underwent SBRT primary or metastatic lesions from 2007 2015 whom genetic testing data available EGFR, AKT,...
OBJECTIVE Spinal stereotactic body radiation therapy (SBRT) has emerged as an attractive method to deliver high doses of oligometastatic spinal tumors with radioresistant histology. Because SBRT is a palliative therapy, attention potential toxicities paramount when counseling patients. The objective this study was report radiation-induced myositis after SBRT, previously undescribed complication. METHODS A total 667 patients received 891 spine treatments (either 24 Gy in 1 fraction or 27 3...
Abstract Purpose Multidisciplinary tumor boards (TB) are the standard for discussing complex head and neck cancer cases. During TB, imaging microscopic pathology is reviewed, but there typically no visualization of resected cancer. Methods A pilot study was conducted to investigate utility visual reports at weekly TB 10 consecutive weeks. Faculty‐level participants completed a pre‐survey post‐survey assess understanding specimens. Results Providers ( n = 25) across seven medical specialties...