A5043993232- Breast Cancer Treatment Studies
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Medical Imaging Techniques and Applications
- Gastric Cancer Management and Outcomes
- Breast Lesions and Carcinomas
- Colorectal Cancer Surgical Treatments
- Esophageal Cancer Research and Treatment
- Advanced MRI Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Metastasis and carcinoma case studies
- Advanced Radiotherapy Techniques
- DNA Repair Mechanisms
- Cancer and Skin Lesions
- Advanced Neuroimaging Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Estrogen and related hormone effects
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Brain Metastases and Treatment
Vanderbilt University Medical Center
2014-2025
Vanderbilt University
2011-2025
Vanderbilt-Ingram Cancer Center
2008-2025
Breast Cancer Research Foundation
2024
Radiation Oncology Associates
2006-2023
Guntur Medical College
2020
Thoracic Surgery Foundation
2019
Rose Medical Center
2016
City Of Hope National Medical Center
2016
Swedish Medical Center
2016
Triple-negative breast cancer (TNBC) is a highly diverse group of cancers, and subtyping necessary to better identify molecular-based therapies. In this study, we analyzed gene expression (GE) profiles from 21 data sets identified 587 TNBC cases. Cluster analysis 6 subtypes displaying unique GE ontologies, including 2 basal-like (BL1 BL2), an immunomodulatory (IM), mesenchymal (M), stem-like (MSL), luminal androgen receptor (LAR) subtype. Further, allowed us cell line models representative...
The role of epidermal growth factor receptor (EGFR) inhibition in chemoradiation strategies the nonoperative treatment patients with esophageal cancer remains uncertain. To evaluate benefit cetuximab added to concurrent therapy for undergoing carcinoma. A National Cancer Institute (NCI) sponsored, multicenter, phase 3, randomized clinical trial open biopsy-proven carcinoma esophagus. study accrued 344 from 2008 2013. Patients were weekly cisplatin (50 mg/m2), paclitaxel (25 and daily...
Spatial profiling of tissues promises to elucidate tumor-microenvironment interactions and generate prognostic predictive biomarkers. We analyzed single-cell, spatial data from three multiplex imaging technologies: cyclic immunofluorescence (CycIF) we generated 102 breast cancer patients with clinical follow-up, publicly available mass cytometry ion-beam datasets. Similar single-cell phenotyping results across platforms enabled combined analysis epithelial phenotypes delineate subtypes among...
To identify molecular markers of pathologic response to neoadjuvant paclitaxel/radiation treatment, protein and gene expression profiling were done on pretreatment biopsies.Patients with high-risk, operable breast cancer treated three cycles paclitaxel followed by concurrent paclitaxel/radiation. Tumor tissue from biopsies was obtained 19 the 38 patients enrolled in study. Protein serial sections that achieved a complete (pCR) compared those residual disease, non-pCR (NR).Proteomic...
Gemcitabine is effective in the treatment of pancreatic cancer and a potent radiosensitizer. This study assessed safety efficacy full-dose gemcitabine administered before during concurrent three-dimensional conformal radiation (3D-CRT) patients with nonmetastatic cancer.During cycles 1 3, received at 1,000 mg/m(2) on days 8 each 21-day cycle. Cycle 2 included same dose 1, 8, 15 28-day cycle 3D-CRT 36 Gy, fractions 2.4 over 3 weeks. Resectable underwent surgery 4 to 6 weeks after treatment....
The purpose of this pilot study is to determine (1) if early changes in both semiquantitative and quantitative DCE-MRI parameters, observed after the first cycle neoadjuvant chemotherapy breast cancer patients, show significant difference between responders nonresponders (2) these parameters can be used as a prognostic indicator eventual response.Twenty-eight patients were examined using pre-, post-one cycle, just prior surgery. included longest dimension, tumor volume, initial area under...
Although there are considerable data on the use of mathematical modeling to describe tumor growth and response therapy, previous approaches often not form that can be easily applied clinical generate testable predictions in individual patients. Thus, is a clear need develop apply clinically relevant oncologic models amenable available patient yet retain most salient features prediction. In this study we show how biomechanical model initialized constrained by serial patient-specific magnetic...
Purpose Cell size is a fundamental characteristic of all tissues, and changes in cell cancer reflect tumor status response to treatments, such as apoptosis cell‐cycle arrest. Unfortunately, can currently be obtained only by pathological evaluation tissue samples invasively. Previous imaging approaches are limited preclinical MRI scanners or require relatively long acquisition times that impractical for clinical imaging. There need develop cell‐size applications. Methods We propose clinically...
Diffusion-weighted and dynamic contrast-enhanced magnetic resonance imaging (MRI) data of 28 patients were obtained pretreatment, after one cycle, completion all cycles neoadjuvant chemotherapy (NAC). For each patient at time point, the tumor cell number was estimated using apparent diffusion coefficient extravascular extracellular (ve) plasma volume (vp) fractions. The proliferation/death rate cells from first two points in conjunction with logistic model growth, which then used to predict...
This provides a benchmark of dosimetric benefit and clinical cost cone-beam CT-based online adaptive radiotherapy (ART) technology for cervical rectal cancer patients.An emulator CBCT-based ART system was used to simulate more than 300 treatments 13 15 patients. CBCT images were generate replans. To measure resource cost, the six phases workflow timed. evaluate benefit, changes in values assessed. These included minimum dose (Dmin) volume receiving 95% prescription (V95%) planning target...
Subcellular localization regulates BRCA1 function, and is exported to the cytoplasm following DNA damage in a p53-dependent manner. Because more than 50% of solid tumors harbor p53 mutations, it possible that genetically wild-type (wt) functionally abnormal through compromised nuclear-cytoplasmic shuttling sporadic breast cancer patients with dysfunctional p53. In this study, we have investigated mechanisms subcellular distribution damage-induced nuclear export, as well impact on resulting...
Quantitative analysis of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) data requires the accurate determination arterial input function (AIF). A novel method for obtaining AIF is presented here and pharmacokinetic parameters derived from individual population-based AIFs are then compared. Philips 3.0 T Achieva MR scanner was used to obtain 20 DCE-MRI sets ten breast cancer patients prior after one cycle chemotherapy. Using a semi-automated estimate axillary artery, we each...
There is currently a paucity of reliable techniques for predicting the response breast tumors to neoadjuvant chemotherapy. The standard approach monitor gross changes in tumor size as measured by physical exam and/or conventional imaging, but these methods generally do not show whether responding until patient has received many treatment cycles. One promising address this clinical need integrate quantitative vivo imaging data into biomathematical models growth order predict eventual based on...
Abstract Purpose: The aim of this study was to determine the safety and pathologic response rates following neoadjuvant paclitaxel radiation in patients with stage II/III breast cancer evaluate use sequential biopsies allow an vivo assessment biological markers as potential predictive regimen. Patients Methods: high-risk, operable were treated three cycles 175 mg/m2 every 3 weeks, followed by twice-weekly 30 concurrent radiation. Core obtained at baseline 24 72 hours after first cycle...
To employ machine learning methods to predict the eventual therapeutic response of breast cancer patients after a single cycle neoadjuvant chemotherapy (NAC).Quantitative dynamic contrast-enhanced MRI and diffusion-weighted data were acquired on 28 before one NAC. A total 118 semiquantitative quantitative parameters derived from these combined with 11 clinical variables. We used Bayesian logistic regression in combination feature selection using framework for predictive model building.The...
Introduction Although tumor metastases remain significant drivers of mortality, the genetic factors that increase risks are not fully identified. Interleukin 6 (IL-6) has emerged as an important factor in breast cancer progression with IL-6 single nucleotide polymorphism (SNP) variants shown to affect survival. We hypothesized SNPs promoter at rs1800795 patients associated distant metastases. Methods performed initial case-control study using Vanderbilt University Medical Center's BioVU, a...
Abstract Background Triple-negative breast cancer (TNBC) patients are at increased risk for recurrence compared to other subtypes of cancer. Previous evidence showed that adiposity may contribute worsened control. Current measures obesity, such as body-mass index (BMI), poor surrogates adiposity, while visceral-to-subcutaneous ratio (VSR), which can be measured from routine computed tomography (CT) imaging, is a direct measure. We hypothesized VSR stronger predictor with BMI in TNBC....
Abstract Purpose: Neoadjuvant chemotherapy for structure preservation (SP) in nasal and paranasal sinus squamous cell carcinoma (NPNSCC) has been described single-institution but not randomized studies. EA3163 was a study investigating whether cytoreductive neoadjuvant would improve SP or overall survival (OS). Patients Methods: with T3/T4a select T4b NPNSCC requiring orbital base of skull (BOS) resection were to surgery (Arm A), versus preceded by docetaxel/cisplatin x3 cycles B). Degree...
Abstract By fitting dynamic contrast‐enhanced MRI data to an appropriate pharmacokinetic model, quantitative physiological parameters can be estimated. In this study, we compare four different models by applying statistical measures assess their ability describe obtained in 28 human breast cancer patient sets: the chi‐square test (χ 2 ), Durbin–Watson statistic, Akaike information criterion, and Bayesian criterion. The include fast exchange limit model with (FXL_ v p ) without (FXL) a plasma...
The purpose of this study is to investigate the ability multivariate analysis dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted MRI (DW-MRI) parametric maps, obtained early in course therapy, predict which patients will achieve pathologic complete response (pCR) at time surgery. Thirty-three underwent DCE-MRI (to estimate K (trans), v e, k ep, p) DW-MRI [to apparent diffusion coefficient (ADC)] baseline (t 1) after first cycle neoadjuvant chemotherapy 2)....
BACKGROUND More than 80,000 postmenopausal breast cancer patients in the United States each year are estimated to begin a 5‐year course of aromatase inhibitors (AIs) prevent recurrence. AI‐related arthralgia (joint pain and/or stiffness) may contribute nonadherence, but longitudinal data needed on risk factors, trajectories, and background postmenopause. This study sought describe 1‐year trajectories baseline covariates among with AI comparison group. METHODS Patients initiating AIs (n = 91)...