A5081538316- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- TGF-β signaling in diseases
- Neuroendocrine Tumor Research Advances
- Vascular Tumors and Angiosarcomas
- Pneumocystis jirovecii pneumonia detection and treatment
- RNA modifications and cancer
- BRCA gene mutations in cancer
- Heat shock proteins research
- PARP inhibition in cancer therapy
- Advanced Antenna and Metasurface Technologies
- CRISPR and Genetic Engineering
- Cancer and Skin Lesions
- Optical Coherence Tomography Applications
- PI3K/AKT/mTOR signaling in cancer
- Intraperitoneal and Appendiceal Malignancies
- Wnt/β-catenin signaling in development and cancer
- Radiomics and Machine Learning in Medical Imaging
First Affiliated Hospital of Guangzhou Medical University
2014-2024
State Key Laboratory of Respiratory Disease
2015-2024
Guangzhou Medical University
2015-2024
Ruijin Hospital
2023
Shanghai Jiao Tong University
2023
National Clinical Research
2019
Nazarbayev University
2017
Arkana Laboratories
2011
Huntsman Cancer Institute
2011
Vanderbilt University
2010-2011
Subcellular localization regulates BRCA1 function, and is exported to the cytoplasm following DNA damage in a p53-dependent manner. Because more than 50% of solid tumors harbor p53 mutations, it possible that genetically wild-type (wt) functionally abnormal through compromised nuclear-cytoplasmic shuttling sporadic breast cancer patients with dysfunctional p53. In this study, we have investigated mechanisms subcellular distribution damage-induced nuclear export, as well impact on resulting...
An increased risk of non-small cell lung cancer (NSCLC) in cystic fibrosis (CF) patients and carriers CF transmembrane conductance regulator (CFTR) mutations has been proposed. However, the role CFTR remains controversial. In present study, expression was assessed 165 NSCLC tumors 22 normal samples with validation an independent series 131 samples. The effect gain loss on malignant behavior examined. manipulation tumor metastasis examined a mouse model. Expression downregulated (p=0.041)....
The tumor suppressor BRCA1 is a nuclear shuttling protein. However, the role of localization in control its functions remains to be elucidated. Given central DNA damage repair, we hypothesized that depletion would compromise function repair and thereby result enhanced cytotoxic response damage. In this study, showed double-strand breaks required nucleus. addition, sequestering cytosol ionizing radiation or cisplatin human breast colon cancer cells. further genetic dissection mechanism...
Heat shock proteins (HSPs) are capable of promoting antigen presentation chaperoned peptides through interactions with receptors on presenting cells. This property HSPs suggests a potential function as an adjuvant-free carrier to stimulate immune responses against covalently linked fusion partner. MAGE-A1 is likely candidate for tumor immunotherapy due its abundant immunogenic epitopes and strict specificity. To analyze the influence HSP70 conjugation MAGE-A1, towards developing novel...
High frequency loss of 3p21.3 region is a common event in various kinds tumors including nasopharyngeal carcinoma (NPC). RASSF1A has been identified as putative tumor suppressor gene residing this region. Chromosome alterations and epigenetic changes are commonly observed mechanisms for inactivation function. In study, we applied the PCR-cloning-sequencing strategy to examine somatic mutations NPC tissues compared with sequences detected matched peripheral blood lymphocytes. Our results...
The metabolic activity of fumarase (FH) participates in gene transcription linking to tumor cell growth. However, whether this effect is implicated lung cancer remains unclear. Here, we show TGFβ induces p38-mediated FH phosphorylation at Thr 90, which leads a FH/CSL (also known as RBP-Jκ)/p53 complex formation and accumulation p21 promoter under concomitant activation Notch signaling; turn, inhibits histone H3 Lys 36 demethylation thereby promotes growth arrest. In addition, massively...
Checkpoint inhibitor-related pneumonitis (CIP) is a lethal immune-related adverse event. However, the development process of CIP, which may provide insight into more effective management, has not been extensively examined. We conducted multicenter retrospective analysis 56 patients who developed CIP. Clinical characteristics, radiological features, histologic and laboratory tests were analyzed. After comprehensive analysis, we proposed acute, subacute, chronic phases CIP summarized each...
Malignant mesothelioma (MM) is a rare but highly aggressive neoplasm. It has poor prognosis and median survival time of 20 months after diagnosis (1). Tumor development associated with exposure to several known carcinogens such as asbestos fiber, rhesus virus 40, radiation, which the most important risk factor (2). The early clinical symptoms MM lack specificity are often characterized by large amounts pleural effusion, make imaging diagnoses difficult. Mesothelioma goes undiagnosed until...
Recent genome-wide association studies (GWASs) have identified 15q25.1 as a lung cancer susceptibility locus. Here, we sought to explore the direct carcinogenic effects of genetic variants in this region on risk developing adenocarcinoma (ADC). Five common SNPs (rs8034191, rs16969968, rs1051730, rs938682, and rs8042374) spanning locus were assayed case-control study examining cohort 301 ADCs 318 healthy controls. Stratification analysis by gender, smoking status, tumor, node, metastasis...
Though ultrasound-guided percutaneous lung needle biopsy (US-PLNB) is a first-line small method for peripheral lesions, quality of cellularity in specimens obtained via US-PLNB uncertain. This study investigated the accuracy, sensitivity, and US-PLNB. It examined ability contrast-enhanced ultrasound (CEUS) to improve effectiveness US-PLNB.We retrospectively analyzed all data patients with subpleural lesions who underwent The from malignant included tumor cell number proportion. definition...
A Chinese male patient with advanced lung adenocarcinoma experienced disease progression one and a half years after receiving first-line immunochemotherapy. The second biopsy was performed tissue immunohistochemistry revealed Anaplastic lymphoma kinase (ALK) expression in the cytoplasm of tumor cells, so he began to receive Alectinib treatment. Then next generation sequencing found double fusion variants S1 RNA binding domain 1 (SRBD1)- ALK ALK- Calcium voltage-gated channel subunit alpha1 D...
The aim of the present study was to determine frequency and predictive value expression tumor microtubule components in patients with resected non-small cell lung cancer (R-NSCLC) subsequently treated vinorelbine-based adjuvant chemotherapy. evaluated 85 R-NSCLC samples using immunohistochemistry. All received protein for disease-free survival (DFS) overall (OS) assessed. not associated any baseline clinicopathological factors patients. High levels class III β-tubulin were correlated an...
The treatment of anaplastic lymphoma kinase (ALK)-positive locally advanced non-small-cell lung cancer (NSCLC) is challenging because there no randomized controlled trial has been reported. value neoadjuvant and adjuvant targeted therapy remains unclear. Herein, we show that systemic with ALK inhibitor crizotinib before surgery can provide the potential to cure initially inoperable tumor. A 27-year-old man was diagnosed a stage IIIAcT3N2M0 (7 th UICC/AJCC) upper left adenocarcinoma harboring...
Appendiceal or cecal endometriosis with intestinal metaplasia is uncommon and may mimic mucinous tumors of the appendix. A 50-year-old woman was found incidentally to have an ileocecal lesion. In intraoperative histological examination, a diagnosis neoplasm cecum made predominantly based on mucin extrusion scattered lining epithelium. However, postoperative lesion as determined by thoroughly microscopic inspection presence typical endometrial glands surrounding endometrial-type stroma. There...
Mucinous metaplasia occurs uncommonly in cutaneous pathology, usually at specialized anatomic locations (genitalia, palms, and soles) within restricted pathologic contexts (inflammation trauma). Here, we report a unique case of eccrine mucinous associated with an apocrine cystadenoma. A 13‐year‐old girl had asymptomatic, 4‐mm nodule on the chest. Histopathology demonstrated typical cystadenoma upper middle dermis. Adjacent to this lesion was cluster coiled secretory glands, which inner layer...