A5101846374- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cervical Cancer and HPV Research
- Cancer-related Molecular Pathways
- Genital Health and Disease
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Pancreatic function and diabetes
- MicroRNA in disease regulation
- Clusterin in disease pathology
- Hippo pathway signaling and YAP/TAZ
- Periodontal Regeneration and Treatments
- Redox biology and oxidative stress
- Medical Research and Treatments
- DNA and Nucleic Acid Chemistry
- Ferroptosis and cancer prognosis
- Wnt/β-catenin signaling in development and cancer
- Virus-based gene therapy research
- Knee injuries and reconstruction techniques
- Ubiquitin and proteasome pathways
- Immune cells in cancer
- Extracellular vesicles in disease
- 14-3-3 protein interactions
- Cancer-related gene regulation
- Infectious Diseases and Mycology
Tsinghua–Berkeley Shenzhen Institute
2024-2025
University of Cambridge
2021-2024
University of Southampton
2024
Tsinghua University
2024
Henan Cancer Hospital
2023
Zhengzhou University
2023
Shanghai Cancer Institute
2021-2022
Shanghai Jiao Tong University
2021-2022
State Key Laboratory of Oncogene and Related Genes
2019-2021
Renji Hospital
2021
Reprogrammed cell metabolism is deemed as one of the hallmarks cancer. Hexosamine biosynthesis pathway (HBP) acts an "energy sensor" in cells to regulate metabolic fluxes. Glutamine-fructose-6-phosphate amidotransferase 1 (GFAT1), rate-limiting enzyme HBP, broadly found with elevated expression human cancers though its exact and concrete role tumorigenesis still remains unknown needs further investigation. P38 mitogen-activated protein kinase (MAPK) important component stress-signaling plays...
Persistent infection with high-risk HPV types can lead to development of HPV-associated cancers, and persistent low-risk causes problematic diseases, such as recurrent respiratory papillomatosis. The management treatment these conditions pose a considerable economic burden.
Human papillomaviruses (HPV) cause persistent infections by modulating epithelial homeostasis in cells of the infected basal layer. Using FUCCI and cell-cell competition assays, we have identifed regulatory roles for E6AP NHERF1, which are primary HPV11 E6 cellular targets, as well being targets high-risk proteins, processes governing (i.e. cell density, cycle entry, commitment to differentiation layer delamination). Depletion E6AP, or expression 16E6 increased keratinocyte density activity,...
The metabolic activity of fumarase (FH) participates in gene transcription linking to tumor cell growth. However, whether this effect is implicated lung cancer remains unclear. Here, we show TGFβ induces p38-mediated FH phosphorylation at Thr 90, which leads a FH/CSL (also known as RBP-Jκ)/p53 complex formation and accumulation p21 promoter under concomitant activation Notch signaling; turn, inhibits histone H3 Lys 36 demethylation thereby promotes growth arrest. In addition, massively...
Abstract Human papillomavirus (HPV) drives high-grade intraepithelial neoplasia and cancer; for unknown reasons, this occurs most often in the cervical transformation zone. Either mutation or HPV E6–driven inhibition of Notch1 can drive neoplastic development stratified squamous epithelia. However, contribution its Delta-like ligands (DLL) to site susceptibility remains poorly understood. Here, we map DLL1/DLL4 expression cell populations present normal biopsies by immunofluorescence. In...
Two APOBEC (apolipoprotein-B mRNA editing enzyme catalytic polypeptide-like) DNA cytosine deaminase enzymes (APOBEC3A and APOBEC3B) generate somatic mutations in cancer, driving tumour development drug resistance. Here we used single cell RNA sequencing to study
The proline synthesis is importantly involved in tumor growth under hypoxia, while the underlying mechanism remains to be further investigated. Here we show that pyrroline-5-carpoxylate reductase-1 (PYCR1), displaying a constant nuclear localization, phosphorylated by IGF1R at Tyrosine 135 hypoxia; this phosphorylation promotes binding of PYCR1 ELK4 and thus recruitment ELK4-targeted genes promoter. Under ELK4-binding ability enzymatic activity are both required for ELK4-Sirt7-mediated...
Extracorporeal cardiac shock wave (SW) therapy is an effective, safe, and non-invasive therapeutic strategy for severe coronary artery disease.Shock might affect tissues because of its ability to promote angiogenesis.In this report, we investigated if the up-regulation vascular endothelial growth factor (VEGF) by SW involved in cell proliferation cultured cells.After human umbilical vein cells were treated with SW, expression secretion VEGF as well analyzed.We also determined mechanism...
Autologous osteochondral transplantation (AOT) is a method for articular cartilage repair. However, several disadvantages of this have been reported, such as transplanted degeneration and the lack connection between grafted adjacent tissues. To evaluate effect intra-articular administration trichostatin A (TSA) on AOT, we conducted case control study in rabbit model. International Cartilage Repair Society (ICRS) macroscopic scores, modified O’Driscoll histology real-time PCR were utilized to...
Abstract Human papillomaviruses (HPV) typically cause chronic infections by modulating homeostasis of infected basal cell to ensure persistence. Using FUCCI and cell-cell competition assays, we established the role two common viral targets low-risk high-risk E6 proteins, E6AP NHERF1, on four key components epithelial homeostasis. These includes density, proliferation, commitment differentiation layer delamination. Our RNA sequencing results validated E6’s effects revealed similar...