A5101899529- Synthesis and Biological Evaluation
- DNA and Nucleic Acid Chemistry
- Cancer Genomics and Diagnostics
- interferon and immune responses
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Chemical Synthesis and Analysis
- Synthesis and Reactions of Organic Compounds
- Cancer therapeutics and mechanisms
- Human-Animal Interaction Studies
- Virus-based gene therapy research
- Marine Ecology and Invasive Species
- Veterinary Medicine and Surgery
- Veterinary Practice and Education Studies
- CRISPR and Genetic Engineering
- Marine Biology and Environmental Chemistry
- RNA Research and Splicing
- Marine Sponges and Natural Products
- Single-cell and spatial transcriptomics
University of Kent
2019-2024
University of Southampton
2024
Fisheries and Oceans Canada
2022
University of British Columbia
2022
Institute of Cancer Research
1999
Abstract Two APOBEC DNA cytosine deaminase enzymes, APOBEC3A and APOBEC3B, generate somatic mutations in cancer, thereby driving tumour development drug resistance. Here, we used single-cell RNA sequencing to study APOBEC3B expression healthy malignant mucosal epithelia, validating key observations with immunohistochemistry, spatial transcriptomics functional experiments. Whereas is expressed keratinocytes entering mitosis, show that confined largely terminally differentiating cells requires...
A series of bis-benzimidazole compounds with a head-to-head orientation have been designed as sequence-specific DNA binders; crystallographic analysis oligonucleotide complexes has combined DNase I footprinting to confirm that the predicted optimal site for core motif is four-base-pair sequence 5′-AATT; this specificity results in inhibition transcription at A/T sites and may be responsible cytotoxic antitumour effects shown by these bis-benzimidazoles.
Two APOBEC (apolipoprotein-B mRNA editing enzyme catalytic polypeptide-like) DNA cytosine deaminase enzymes (APOBEC3A and APOBEC3B) generate somatic mutations in cancer, driving tumour development drug resistance. Here we used single cell RNA sequencing to study
Veterinary nurses are directly involved with providing advice and gaining informed consent for ovariohysterectomy in bitches. In order to allow them provide accurate information regarding this common procedure it is vital they fully understand the potential advantages disadvantages procedure. It very easy clients gain information, often inaccurate, from internet sources so be able correct evidence-based therefore confidence of client, implications any surgery which consent. accountable their...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”