A5016843956- Statistical Methods and Inference
- Chinese history and philosophy
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Vascular Tumors and Angiosarcomas
- Statistical Methods in Clinical Trials
- Advanced Causal Inference Techniques
- Simulation-Based Education in Healthcare
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Control Systems and Identification
- Pharmacological Effects of Natural Compounds
- Interprofessional Education and Collaboration
- Statistical Methods and Bayesian Inference
- Endometriosis Research and Treatment
- RNA modifications and cancer
- RNA Research and Splicing
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Probiotics and Fermented Foods
- Tuberous Sclerosis Complex Research
- Optimism, Hope, and Well-being
- Human Motion and Animation
- Vascular Malformations and Hemangiomas
- Acute Myeloid Leukemia Research
Chinese Academy of Sciences
2025
Weatherford College
2024
Jinan University
2013-2024
Ocean University of China
2020-2024
Shanghai Ocean University
2023-2024
Third Xiangya Hospital
2024
Central South University
2024
Qingdao University
2024
First Affiliated Hospital of Zhengzhou University
2024
Shanxi Medical University
2023
In this study, the effectors and mechanisms of Bifidobacterium bifidum FL-276.1 B. FL-228.1 in alleviating dextran sulfate sodium (DSS)-induced colitis were investigated. Both significantly alleviated DSS-induced colitis, whether they supplemented from beginning experiment (whole course intervention) or after DSS induction started (partial intervention). Aryl hydrocarbon receptor (AHR) nuclear factor erythroid 2-related 2 (NRF2) pathways activated mice colons, while NLR family pyrin domain...
Osteoporosis has become one of the major diseases that threaten health middle-aged and elderly people, with growth an ageing population, more people are affected by osteoporosis these days. In recent years, intestinal flora been found to affect host immune system, overactive system is closely related bone resorption. Probiotics can effectively improve density strength, reduce loss, osteoporosis, but their mechanism action relationship microbiota still unclear. this study, two strains...
Inspired by sample splitting and the reusable holdout introduced in field of differential privacy, we consider selective inference with a randomized response. We discuss two major advantages using response for model selection. First, selectively valid tests are more powerful after Second, it allows consistent estimation weak convergence procedures. Under independent sampling, prove (or privatized) central limit theorem that transfers procedures under asymptotic normality without selection to...
Hyperuricemia (HUA) is the presence of excessive uric acid (UA) in blood, which leads to an increased risk chronic kidney disease and gout. Probiotics have potential effect alleviating HUA. The purpose this study was screen probiotics with UA-lowering activity explore underlying mechanism. 20 lactic bacteria strains investigated
Significance In modern hospital systems where complicated, severely ill patient populations are the norm, there is currently no reliable way to forecast use of perishable medical resources enable a smart and economic deliver optimal care. We here demonstrate statistical model using data quantitatively forecast, days in advance, need for platelet transfusions. This approach can be leveraged significantly decrease wastage, and, if adopted nationwide, would save approximately 80 million dollars...
Inflammatory bowel disease (IBD) characterized by relapsed intestinal inflammation and barrier function disruption is still a great therapeutic challenge. This study aimed to screen probiotics that have the potential help alleviate IBD further elucidate their mechanism of action. Caco-2 cell differentiated monolayers RAW264.7 cells stimulated lipopolysaccharide (LPS) were used for probiotic screening in vitro, then efficacies obtained six bacterial strains evaluated mice with dextran sulfate...
Osteoarthritis (OA) is the most common joint disease primarily characterized by cartilage degeneration. Milk-derived extracellular vesicles (mEVs) were reported to inhibit catabolic and inflammatory processes in of OA patients. However, current therapies target advanced symptoms OA, it significant develop a novel strategy driving pathology. In this study, we investigated therapeutic potential mEVs alleviating vivo. The results revealed that ameliorated degeneration increasing hyaline...
This study aimed to explore the effect of <i>Bif. Animalis</i> F1-7 on improvement atherosclerotic inflammation. Arteriosclerosis model ApoE<sup>-/-</sup> mice were orally administered with for 12 weeks. The probiotic intervention reduced plaque areas in aorta and accumulation macrophages, downregulated expression toll-like receptor 4 (TLR4)/nuclear factor‑κB (NFκB) pathway reduce levels inflammatory factors. widely-targeted metabolomics analysis showed that acetyl-L-carnitine (ALC)...
Abstract Background Delirium is prevalent in ischemic stroke patients, particularly those the intensive care unit (ICU), and it poses a significant burden on patients caregivers, leading to increased mortality rates, prolonged hospital stays, impaired cognitive function. Dysphagia, common symptom critically ill with stroke, further complicates their condition. However, association between dysphagia delirium this context remains unclear. The objective of study was investigate correlation ICU...
To evaluate the effect of biodegradable magnesium alloy materials in promoting tendon-bone healing during rotator cuff tear repair and to investigate their potential underlying biological mechanisms. Forty-eight 8-week-old Sprague Dawley rats were taken randomly divided into groups A, B, C. Rotator models created repaired using sutures group A Vicryl Plus 4-0 absorbable while only subcutaneous incisions performed Organ samples B for HE staining at 1 2 weeks after operation safety alloy,...
Abstract In this paper, we seek to establish asymptotic results for selective inference procedures removing the assumption of Gaussianity. The class selection consider are determined by affine inequalities, which refer as procedures. Examples include along solution path least absolute shrinkage and operator (LASSO), well after fitting at a fixed value regularization parameter. We also some tests in penalized generalized linear models. Our result proves convergence high‐dimensional setting...
The damage of vascular endothelial cells induced by oxidative stress plays an important role in the pathogenesis atherosclerosis. Dihydromyricetin (DMY) is considered as a natural antioxidant. However, mechanism DMY on cell injury remains unclear. In this study, we found that could reduce HUVECs sodium nitroprusside (SNP), pre-treated with suppressed SNP-induced apoptosis reduced ROS overproduction intracellular, decreased MDA level and elevated superoxide dismutase activity. Meanwhile,...
We aim at the association of macrophage migration inhibitory factor (MIF) with neovascularization and survival nasopharyngeal carcinoma (NPC), determine whether MIF is a valuable prognostic predictor for NPC patients.One hundred forty one cases 25 normal tissues nasopharynx were collected. The expression interleukin 8 (IL-8) was evaluated in microarray by immunostaining. Intratumoral microvessel density (IMD) relation to immunostainings clinicopathological factors analyzed statistically as...
There has been much recent work on inference after model selection in situations where the noise level is known. However, error variance rarely known practice and its estimation difficult high-dimensional settings. In this we propose using square-root lasso, also as scaled to perform for selected coefficients simultaneously. The lasso property that choice of a reasonable tuning parameter does not depend data. We provide valid |$p$|-values confidence intervals variable estimates...
Food allergy has become a world recognized public health problem due to its versatility and lack of efficacious methods for treatment. Probiotics supplement is potential way prevent food allergy.In this study, strains are screen out by peripheral blood mononuclear cells (PBMCs), their abilities alleviating examined using mouse model induced ovalbumin (OVA). The results show that six increase ratio interferon-γ (IFN-γ)/interleukin (IL)-4 secreted PBMCs with good in intestinal adhesion...
Antineutrophil cytoplasmic antibody vasculitis-associated interstitial lung disease (AAV-ILD) is a potentially life-threatening disease. However, very little research has been done on the condition’s mortality risk. Hence, our objective to find out factors influencing prognosis of AAV-ILD and employ these findings create nomogram model. Patients with who received treatment at First Affiliated Hospital Zhengzhou University during period from March 1, 2011, April 2022 were selected for this...