A5064240180- Intensive Care Unit Cognitive Disorders
- Dementia and Cognitive Impairment Research
- Nutritional Studies and Diet
- Sepsis Diagnosis and Treatment
- Health, Environment, Cognitive Aging
- Nutrition and Health in Aging
- Folate and B Vitamins Research
- Venous Thromboembolism Diagnosis and Management
- Dysphagia Assessment and Management
- Anesthesia and Sedative Agents
- Radiomics and Machine Learning in Medical Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Esophageal and GI Pathology
- Respiratory Support and Mechanisms
- Birth, Development, and Health
- Frailty in Older Adults
- Neonatal and fetal brain pathology
- Acute Ischemic Stroke Management
- Hemodynamic Monitoring and Therapy
- Pneumonia and Respiratory Infections
- Child Nutrition and Feeding Issues
- Fluoride Effects and Removal
- Healthcare Decision-Making and Restraints
- Renal function and acid-base balance
- Spondyloarthritis Studies and Treatments
First Affiliated Hospital of Jinan University
2022-2025
Objective To explore the correlations of high-density lipoprotein cholesterol (HDL-C)/low-density (LDL-C) with myocardial infarction (MI), all-cause mortality, haemorrhagic stroke and ischaemic stroke, as well joint association genetic susceptibility HDL-C/LDL-C MI risk. Methods results This study selected 384 093 participants from UK Biobank (UKB) database. First, restricted cubic splines indicated non-linear associations MI, mortality. Second, a Cox proportional-hazards model that compared...
Abstract Background Delirium is prevalent in ischemic stroke patients, particularly those the intensive care unit (ICU), and it poses a significant burden on patients caregivers, leading to increased mortality rates, prolonged hospital stays, impaired cognitive function. Dysphagia, common symptom critically ill with stroke, further complicates their condition. However, association between dysphagia delirium this context remains unclear. The objective of study was investigate correlation ICU...
Background Previous research on how changes in CRP (C‐reactive protein) levels predict stroke risk is limited. This study aimed to examine the association between change and of its subtypes. Methods Results Based UK Biobank data, we investigated subtypes with Cox proportional hazards regression analysis. We further performed genetic analyses including correlation, pairwise genome‐wide study, polygenic score. Our involved 14 754 participants a median follow‐up time 10.4 years. After...
Abstract Background The association between body mass index (BMI) and Alzheimer's disease (AD) remains controversial. Genetic environmental factors are now considered contributors to AD risk. However, little is known about the potential interaction genetic risk BMI on Objective To study causal relationship AD, Methods Results Using UK Biobank database, 475,813 participants were selected for an average follow-up time of more than 10 years. Main findings: 1) there was a nonlinear in aged 60...
Dysphagia is common in elderly patients with dementia and one of the clinical geriatric syndromes. It imposes a heavy burden on their caregivers becoming an important public health problem. This study examined association between dysphagia older ICU subsequent adverse outcomes they experience.A retrospective analysis adults (≥65 years) ICUs Boston tertiary academic medical center was conducted. Using International Classification Diseases' Ninth Tenth Revisions, were identified. The cohort...
The triglyceride-glucose index (TyG), an established indicator of insulin resistance, is closely correlated with the prognosis several metabolic disorders. This study aims to investigate association between TyG and incidence critical delirium in patients aged 65 years older.We focused on evaluating older diagnosed delirium. Data were obtained from Medical Information Database for Intensive Care (MIMIC-IV) eICU Collaborative Research (eICU-CRD). Multivariate logistic regression restricted...
To prospectively assess whether air pollution, including PM2.5, PM10, and NOx, is associated with the risk of all-cause dementia, Alzheimer's disease (AD), vascular to investigate potential relationship between pollution genetic susceptibility in development AD.Our study included 437,932 participants from UK Biobank a median follow-up period over 10 years. Using Cox proportional hazards model, we found that exposed PM2.5 levels ≥10 μg/m3 had higher developing dementia (HR = 1.1; 95% CI:...
Abstract Previous researchers have tried to explore the association between folate/folic acid intake and dementia incidence, but results remain controversial. We evaluated associations of supplementation alone in combination with other B vitamins on risk brain structure. A total 466 224 UK Biobank participants were investigated. Cox proportional hazards models used assess status Alzheimer’s disease (AD) vascular (VD). Multivariable linear regression employed evaluate In final model, was...
Providing intensive care is increasingly expensive, and the aim of this study was to construct a risk column line graph (nomograms)for prolonged length stay (LOS) in unit (ICU) for patients with chronic obstructive pulmonary disease (COPD).This included 4,940 patients, data set randomly divided into training (n = 3,458) validation 1,482) sets at 7:3 ratio. First, least absolute shrinkage selection operator (LASSO) regression analysis used optimize variable by running tenfold k-cyclic...
The hemoglobin-to-red cell distribution width ratio (HRR) is associated with the prognosis of sepsis-associated encephalopathy (SAE). This study aimed to determine relationship between HRR and SAE clarify possible mechanism as a prognostic factor for SAE.A multivariate Cox proportional-hazards regression model was used assess correlation all-cause mortality. Piecewise linear smooth-curve models were observe whether there nonlinear mortality in SAE.This included 8853 patients SAE. A observed...
Although there has been a large amount of research focusing on medical image classification, few studies have focused specifically the portable chest X-ray. To determine feasibility transfer learning method for detecting atelectasis with X-ray and its application to external validation, based analysis dataset.From intensive care information market (MIMIC-CXR) database, 14 categories were obtained using natural language processing tags, among which 45,808 frontal radiographs labeled as...
Objective: This study analyzed the association of gastric acid secretion inhibitors (GASIs) [including proton pump (PPIs) and histamine 2 receptor antagonists (H2RAs)] with occurrence ventilator-associated pneumonia (VAP) in-hospital mortality in patients who received invasive mechanical ventilation (IMV). Method: Patients IMV used GASI were included based on records MIMIC-IV database. The relationships GASIs VAP determined using univariate multivariate logistic regression analyses. Also,...
To investigate the association between kidney function with risk of dementia and brain volumes.A total 452,996 UK Biobank participants calculated glomerular filtration rate (eGFR) albumin-to-creatinine ratio (ACR) were included. We utilized Cox proportional hazards regression models restricted cubic spline analyses to examine relationships all-cause (ACD), Alzheimer's disease (AD), vascular (VD). Additionally, we explored correlations magnetic resonance indicators among 40,380...
Abstract Aims and Objectives To investigate whether a low Braden Skin Score (BSS), reflecting an increased risk of pressure injury, could predict the delirium in older patients intensive care unit (ICU). Background Delirium, common acute encephalopathy syndrome ICU patients, is associated with prolonged hospital stay, long‐term cognitive impairment mortality. However, few studies have explored relationship between BSS delirium. Design Multicenter cohort study. Methods The study included...
ABSTRACT Aims and Objectives To provide a viable tool for the early clinical identification of high‐risk populations in patients with sepsis. Background Sepsis‐associated delirium (SAD) has potential to significantly impact short‐ long‐term prognosis patients. However, accurately predicting effectively managing SAD remains significant challenge. Methods This study employed retrospective analysis adult sepsis admitted intensive care unit (ICU) first time. Patients were divided into two groups...
<title>Abstract</title> <bold>Purpose:</bold> To prospectively assess whether Healthy Aging Index (HAI) is associated with the risk of dementia, and to investigate potential relationship between HAI genetic susceptibility in development Alzheimer's disease (AD). <bold>Methods:</bold> The study included 305,566 participants from UK Biobank, a median follow-up 14.01 years. components were systolic blood pressure, reaction time, forced vital capacity, serum cystatin c, glucose. Cox proportional...