A5050496075- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Anorectal Disease Treatments and Outcomes
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- Pelvic floor disorders treatments
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Neuroendocrine Tumor Research Advances
- Nonmelanoma Skin Cancer Studies
- Brain Metastases and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Medicinal plant effects and applications
- Autophagy in Disease and Therapy
- Stoma care and complications
- Adrenal Hormones and Disorders
- Inflammatory Myopathies and Dermatomyositis
- Malaria Research and Control
- Abdominal Surgery and Complications
- Eicosanoids and Hypertension Pharmacology
- Heme Oxygenase-1 and Carbon Monoxide
Union Hospital
2024-2025
Huazhong University of Science and Technology
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Hebei University of Technology
2025
Peking Union Medical College Hospital
2021-2025
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Jinan University
2019-2021
Union Hospital
2021
Tianjin Medical University
2016
Colorectal cancer (CRC) is the second leading cause of cancer-induced death in world. Cancer-associated fibroblasts (CAFs) released exosomes that contributed to progression. This research was carried out study influence CRC-associated fibroblasts-derived on phenotype CRC cells and underlying mechanism. CAFs-derived (CAFs-exo) normal (NFs)-derived (NFs-exo) were recognized by transmission electronic microscopy, nanoparticle tracking analysis western blot analysis. Cell counting kit-8, flow...
Aloperine (ALO), a quinolizidine-type alkaloid isolated from natural Chinese herb, has shown promising antitumor effects. Nevertheless, its common mechanism of action and specific target remain elusive. Here, it is demonstrated that ALO inhibits the proliferation migration non-small cell lung cancer lines in vitro tumor development several mouse models vivo. Mechanistically, fusion autophagosomes with lysosomes autophagic flux, leading to accumulation sequestosome-1 (SQSTM1) production...
Background The traditional neoadjuvant chemoradiotherapy (nCRT) combined with total mesorectal excision has been widely accepted as the standard treatment for patients locally advanced rectal cancer (LARC). New strategies such therapy (TNT) and immunotherapy have shown great promise in certain patient populations. Currently, there is an urgent need to stratify before adopt appropriate strategies. Our previous study that circulating tumour DNA (ctDNA) effectively reflects burden genetic...
To evaluate the predictive value of MRI-determined variables for pathological complete response (pCR) in locally advanced rectal cancer (LARC) patients following neoadjuvant chemoradiotherapy (NCRT). Clinical data were collected from who received NCRT between January 2019 and 2022. Patients with adenocarcinoma, cT3-4N0, or TanyN1-2 included. pCR was defined pT0N0. divided into non-pCR group. Logistic regression analysis performed to identify factors associated pCR. A nomogram model...
The damage of vascular endothelial cells induced by oxidative stress plays an important role in the pathogenesis atherosclerosis. Dihydromyricetin (DMY) is considered as a natural antioxidant. However, mechanism DMY on cell injury remains unclear. In this study, we found that could reduce HUVECs sodium nitroprusside (SNP), pre-treated with suppressed SNP-induced apoptosis reduced ROS overproduction intracellular, decreased MDA level and elevated superoxide dismutase activity. Meanwhile,...
Background Conformal proctectomy with sphincter preservation (CPSP) is designed to preserve the rectal wall as much possible in very low cancer patients. Evaluations of anal function and quality life outcomes are lacking. Methods This study included male patients (≤ 5 cm from verge) adenocarcinoma between January 1, 2020, 2022. A LARS score questionnaire survey EORTC-QLQ-CR38 were administered. Results total 21 enrolled follow-up. The average age was 56.7 years, tumors 1.9 ± 0.6 size,...
Chorioamnionitis is associated with an increased risk of spontaneous preterm birth. The aim this study was to investigate the serum levels high mobility group box-1 (HMGB1) in pregnancies histological chorioamnionitis (HCA)-associated labor (PTL) intact membranes or premature rupture (PPROM), and access role HMGB1 HCA HCA-associated PTL. A total 190 pregnant women were enrolled study: PLT patients (n = 28) without 36), PPROM 26) 65), non-HCA PTL controls 35). Maternal measured by...
Rectal cancer (RC) is one of the most common malignant tumors. Ferroptosis an iron-dependent form cell death, which plays important role in various cancers. However, correlation between ferroptosis-related genes (FRGs) and prognosis RC remains unclear.Gene expression data from The Cancer Genome Atlas Rectum adenocarcinoma (TCGA-READ) GSE87211 were downloaded. Clustering functional enrichment evaluated. A FRGs risk score was established based on univariate Cox analysis Least absolute...
Transanal endoscopic microsurgery (TEM) has been accepted worldwide for the treatment of local rectal lesions. We aimed to assess efficacy and safety TEM in neuroendocrine tumors (RNET).A retrospective study patients who had undergone RNET at our institution between December 2006 June 2019 was performed. Demographic tumor characteristics, operative pathological details, complications, anal function questionnaires, follow-up data were included.A total 144 included. performed as primary...
Background: Described by Heald in 1982, total mesorectal excision (TME) is now routinely performed as the standard procedure for mid-low rectal cancer, with remarkable decrease local recurrence and improved oncology outcome. However, integrity of resected mesentery damage to autonomic nerves still remain challenging general surgeons, especially cohort neoadjuvant therapy patients. The concept modular resection (RMR), based on an integral understanding regional anatomy, was proposed a...
Background:The purpose of this study was to assess the efficacy and safety rectal modular dissection (RMD) in male patients with middle low cancer.RMD is a technique used guide surgical procedure for mobilization, ultimate goal achieving total mesorectal excision.In order evaluate effectiveness RMD, single-center, non-inferiority randomized clinical trial carried out.Methods: Eligible were randomly assigned into two groups: RMD group traditional mobilization (TRM) group.Demographic...
Abstract Chemoresistance is a primary contributor to distant metastasis in the context of neoadjuvant chemoradiotherapy (nCRT) rectal cancer, underlying mechanisms remain elusive. In this study, profiles plasma exosome miRNAs were compared two dimensions according treatment responses (poor/well-responders) and courses (pre/post-nCRT) by RNA-sequencing. The hsa-miR-483-5p was up-regulated well-responders post-nCRT. bioinformatic analysis revealed that target genes mainly enriched...
Abstract Background Doctors are at high risk of developing hemorrhoidal disease (HD), but it is unclear whether doctors aware this risk. The OASIS (dOctors AS patIentS) study was performed to examine the prevalence, awareness, diagnosis, and treatment HD among in big cities China. Methods An online survey consisting a structured questionnaire carried out grade-A tertiary hospitals 29 provinces across China from August October 2020. Results A total 1227 responses were collected. prevalence...
Intestinal flora disorder (IFD) poses a significant challenge after laparoscopic colonic surgery, and no standard criteria exists for its diagnosis treatment.
Chemoresistance is the primary contributor to distant metastasis in context of neoadjuvant chemoradiotherapy (nCRT) for rectal cancer. However, underlying mechanisms remain elusive.
To investigate the clinical characteristics of brain metastases after radical surgery for locally advanced rectal cancer (LARC).
Abstract Background Depression is common in the elderly, which regarded as an important risk factor for mild cognitive impairment (MCI), and social participation has been proved to be effective improving mental health of aged, while relationship acting path among depression, occurrence MCI are still unclear. Method This study included 190 older adults with matched without impairment. All participants were asked complete Montreal Cognitive Assessment (MoCA), Participation Autonomy...