A5101585956- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Digestive system and related health
- Ferroptosis and cancer prognosis
- Multiple and Secondary Primary Cancers
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Screening and Detection
- TGF-β signaling in diseases
- Nutrition, Genetics, and Disease
- Toxin Mechanisms and Immunotoxins
- Medical Imaging Techniques and Applications
- Clostridium difficile and Clostridium perfringens research
- Mesenchymal stem cell research
- RNA modifications and cancer
- Cancer Research and Treatments
- Renal cell carcinoma treatment
- Connective tissue disorders research
- Cancer-related Molecular Pathways
- Microscopic Colitis
- Alcohol Consumption and Health Effects
- CRISPR and Genetic Engineering
- Colorectal Cancer Treatments and Studies
- Enhanced Recovery After Surgery
- Connective Tissue Growth Factor Research
- FOXO transcription factor regulation
Beijing Chao-Yang Hospital
2008-2025
Capital Medical University
2008-2022
Sohu (China)
2010
National Natural Science Foundation of China
2008
CAE (Canada)
2006
Peking University
2001-2002
Peking University First Hospital
2001-2002
Background The traditional neoadjuvant chemoradiotherapy (nCRT) combined with total mesorectal excision has been widely accepted as the standard treatment for patients locally advanced rectal cancer (LARC). New strategies such therapy (TNT) and immunotherapy have shown great promise in certain patient populations. Currently, there is an urgent need to stratify before adopt appropriate strategies. Our previous study that circulating tumour DNA (ctDNA) effectively reflects burden genetic...
SIRT2 is a member of sirtuin family and associated with cell growth in various cancers. In this study, we searched for variants functional region gene identify rs2015 rs2241703 the 3'UTR minor allele frequency >0.05 Chinese Han Beijing population from 1000 Genomes Project. We then genotyped these two 842 colorectal cancer (CRC) patients 1,718 healthy controls using Taqman genotyping assay. Association between risk CRC calculated logistic regression adjusted sex age. found that rs2015C was...
Colorectal cancer (CRC) is the 5th leading in China. Alcohol consumption has been reported to be one of risk factors CRC. However, it remains unclear whether genetic variants alcohol metabolic genes are associated with CRC risk. In this study, we tested coding and CRC, by using 485 cases 516 controls. A total 16 germline 10 were genotyped. We identified that rs3741178 ALDH3B2 was significantly odds ratio being 2.13 (95% CI: 1.24-3.68, P=0.0064). Further functional annotation suggested...
Fibulin-5 has recently been considered as a potential tumor suppressor in human cancers. Several studies have shown that it is down-regulated variety of types and inhibits growth metastasis. In this study, the expression fibulin-5 colorectal cancer (CRC) its clinical significance were assessed.Fibulin-5 was detected 31 samples surgically resected CRC paired noncancerous tissues using western blot, qRT-PCR, immunoblotting.In levels protein mRNA compared with those tissues. Low significantly...
Colorectal cancer (CRC) is one of the leading causes cancer-related death worldwide. The existence stem cells (CSC) tumor relapses, metastasis, and resistance to conventional therapy. Alternative splicing has been shown affect physiological pathological processes. Accumulating evidence confirmed that targeting alternative could be an effective strategy treat CRC. Currently, role in regulation CSC properties CRC not elucidated. Here, we show RBM17 displays oncogenic roles cells. enhances cell...
Rationale: Clostridium difficile infection (CDI) is a symptomatic due to the spore-forming bacterium, C. difficile. Asymptomatic colonization stage in absence of symptoms, with prevalence 1.4% 21% on hospital admission. Proton-pump inhibitors (PPIs) was implicated as novel potential contributor CDI. PPIs injection could make asymptomatic progress associated diarrhea (CDAD). Patient concerns: A postoperative colon cancer patient, who had been taking omeprazole for 4 years after operation, got...
To analyze the diagnosis and treatment of 16 hereditary nonpolyposis colorectal cancer (HNPCC) kindreds, to report first kindred with hMLH1 germline mutation in Mainland China.The diagnosis, follow-up study HNPCC kindreds were retrospectively reviewed. Data concerning site malignant tumor, age at history synchronous and/or metachronous cancer, histopathology tumors recorded. All treatments had won formal consent. PCR SSCP used screen coding region hMSH2 genes. Variant bands sequenced by a...
At least five mismatch repair (MMR) genes, including hMSH2, hMLH1, hPMS, hPMS2, and hMSH6/GTBP, are associated with hereditary nonpolyposis colorectal cancer (HNPCC). More than 90% of families HNPCC harbor the hMSH2 hMLH1 gene mutations. We have analyzed clinical features among Chinese patients report results screening for mutations in genes.The data concerning gender, site (CRC), age at diagnosis, history synchronous and/or metachronous cancer, instance extracolonic cancers, histopathology...
<title>Abstract</title> <bold>Background</bold>: Colorectal cancer (CRC) is the third most prevalent diagnosis and leading mortality worldwide. The TSC2 gene recognized for its important role in regulating a multitude of biological processes, with some studies suggesting that it may function as prognostic marker many types tumors. <bold>Methods</bold>: In our study, we enrolled 102 CRC patients conducted next-generation sequencing on their tumor tissues to assess mutations gene. mutation...
Objective To investigate the isolation, culture, biological characteristics and multi-differentiation of porcine adipose-derived stem cells (ADSCs) in vitro. Methods ADSCs were obtained from back subcutaneous adipose tissue by collagenase digestion cultured Flow cytometric analysis cyto-immumofluorescence staining technique carried out to detect immunophenotypes ADSCs. Reverse transcription-polymerase chain reaction (RT-PCR) specific used evaluate multipotential differentiation phenotype...
手术是结直肠癌治疗的难点,也是争论最大、进展最快的领域之一.围绕追求手术的根治性并延长生存期,同时尽量保留肛门功能、提高患者的生活质量的目标,近年来直肠癌手术无论是在理念、具体方法、辅助手段等方面都有了很大的发展.因篇幅所限,本文仅综述近年来直肠癌手术方法的进展。
Objective To assess efficacy and safety of enhanced rehabilitation program for patients with colorectal cancer surgery. Methods One hundred ten consecutive admitted to general surgery department at Beijing Chaoyang Hospital during October 2007 2009 undergone fasttrack were prospectively studied, 117 same by traditional perioperative treatment May 2005 September as controls. Restoration their gastrointestinal function, occurrence complications, fatality length hospital stay after surgical...
Objective: To screen LKB1 mutation in sporadic colon and ovarian tumors. Methods: Using PCR-SSCP analysis, 72 cancer, 45 14 granulosa cell tumor were screened for mutation. Results: no was adenocarcinomas. Two mutations detected one of the tumors: a mis-sense affecting putative start codon (ATG→ACG, MIT); silent change erxon 7 (CTT→CTA, leucine). Conclusion: cancers are rare event is not target gene lost on chromosome 19p13.3 cancers.