A5077744948- Metabolomics and Mass Spectrometry Studies
- Genomics, phytochemicals, and oxidative stress
- Eicosanoids and Hypertension Pharmacology
- Nutritional Studies and Diet
- Parathyroid Disorders and Treatments
- TGF-β signaling in diseases
- Hemodynamic Monitoring and Therapy
- Biomarkers in Disease Mechanisms
- Cardiomyopathy and Myosin Studies
- Diet and metabolism studies
- Cardiovascular Effects of Exercise
- Cancer Cells and Metastasis
- Autophagy in Disease and Therapy
- Calcium signaling and nucleotide metabolism
- Blood Pressure and Hypertension Studies
- Dialysis and Renal Disease Management
- Cardiovascular Function and Risk Factors
- Immune cells in cancer
- Dermatological and Skeletal Disorders
Shandong University of Traditional Chinese Medicine
2019-2024
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2024
This study focused on circulating plasma protein profiles to identify mediators of hypertension-driven myocardial remodeling and heart failure.
Aloperine (ALO), a quinolizidine-type alkaloid isolated from natural Chinese herb, has shown promising antitumor effects. Nevertheless, its common mechanism of action and specific target remain elusive. Here, it is demonstrated that ALO inhibits the proliferation migration non-small cell lung cancer lines in vitro tumor development several mouse models vivo. Mechanistically, fusion autophagosomes with lysosomes autophagic flux, leading to accumulation sequestosome-1 (SQSTM1) production...
Resistant hypertension (RH) may cause severe target organ damage and poses significant challenges in the field of prevention treatment. Mining biological characteristics is crucial for exploring pathogenesis RH early diagnosis Although several single-omics studies have been conducted on RH, its complex has only partially elucidated. In this study, metabolomics, proteomics, transcriptomics were jointly analyzed healthy subjects patients with RH. The multi-omics analysis found that...
Yishenjiangyafang is a traditional Chinese medicine used to clinically treat hypertension. This study aimed explore the effect of yishenjiangyafang on plasma metabolomics in senile spontaneously hypertensive rats (SHRs).Twelve 50-week-old SHR (6 males and 6 females) were randomly divided into two groups: treatment group, which intragastrically administered with (10.08 g kg-1·d-1), model all SHRs same volume saline. Six age- gender-matched Wistar-Kyoto (WKY) as control group. Treatment was...