A5102925531- Cardiac Health and Mental Health
- Simulation-Based Education in Healthcare
- Health Literacy and Information Accessibility
- Diabetes Management and Education
- Chronic Disease Management Strategies
- Biological and pharmacological studies of plants
- Interprofessional Education and Collaboration
- Stroke Rehabilitation and Recovery
- Phytochemistry and Biological Activities
- Healthcare professionals’ stress and burnout
- Technology Use by Older Adults
- Cancer survivorship and care
- Mobile Health and mHealth Applications
- HIV/AIDS Research and Interventions
- Palliative Care and End-of-Life Issues
- Family Support in Illness
- HIV, Drug Use, Sexual Risk
- Education and Critical Thinking Development
- Homelessness and Social Issues
- Cardiac Arrest and Resuscitation
- Medication Adherence and Compliance
- Patient-Provider Communication in Healthcare
- Protein Degradation and Inhibitors
- Posttraumatic Stress Disorder Research
- Hepatocellular Carcinoma Treatment and Prognosis
Jinan University
2014-2025
Therapeutic Guidelines
2025
Jinan University
2024
Guangzhou University of Chinese Medicine
2015-2023
Central South University
2022
First Affiliated Hospital of Jinan University
2021
Zhejiang Center for Disease Control and Prevention
2018
University of Jinan
2018
Yale University
2016-2017
Anhui Medical University
2015
Small molecule inhibitor of the bromodomain and extraterminal domain (BET) family proteins is a promising option for cancer treatment. However, current BET inhibitors are limited by their potency or oral bioavailability. Here we report discovery characterization NHWD-870, that more potent than three major clinical stage BMS-986158, OTX-015, GSK-525762. NHWD-870 causes tumor shrinkage significantly suppresses growth in nine xenograft syngeneic models. In addition to its ability downregulate...
Surgical Nursing is a core subject for nursing undergraduates that requires active and effective learning strategies to cultivate students' autonomous competencies critical thinking. The effects of BOPPPS (Bridge-in, Objectives, Pretest, Participatory Learning, Post-test Summary) model combined with team-based (TBL) have rarely been explored in courses.To explore the TBL undergraduates.A mixed research method quasi-experimental study design descriptive qualitative was used. control group...
Abstract Rationale, aims and objectives Poor medication adherence is a major global public health challenge. A valid, reliable, cost‐effective tool for measuring would lead to better understanding of non‐adherence lay the groundwork interventions aimed at facilitating therapies. The aim this study was translate evaluate psychometric properties Chinese version 8‐item Morisky scale ( C ‐ MMAS ‐8) in myocardial infarction MI ) patients. Methods Psychometric testing ‐8 conducted using...
Aerobic glycolysis is essential for tumor growth and survival. Activation of multiple carcinogenic signals contributes to metabolism reprogramming during malignant transformation cancer. Recently nitric oxide has been noted promote but the mechanism remains elusive. We report here dual role in glycolysis: low/physiological (≤ 100 nM) promotes ATP production, oxidative defense cell proliferation ovary cancer cells, whereas excess (≥ 500 inhibits it. Nitric a positive effect on by inducing...
The damage of vascular endothelial cells induced by oxidative stress plays an important role in the pathogenesis atherosclerosis. Dihydromyricetin (DMY) is considered as a natural antioxidant. However, mechanism DMY on cell injury remains unclear. In this study, we found that could reduce HUVECs sodium nitroprusside (SNP), pre-treated with suppressed SNP-induced apoptosis reduced ROS overproduction intracellular, decreased MDA level and elevated superoxide dismutase activity. Meanwhile,...
Purpose A comprehensive health history contributes to identifying the most appropriate interventions and care priorities. However, history-taking is challenging learn develop for nursing students. Chatbot was suggested by students be used in training. Still, there a lack of clarity regarding needs these programs. This study aimed explore students’ essential components chatbot-based instruction program. Methods qualitative study. Four focus groups, with total 22 students, were recruited....
ABSTRACT Aim To develop a deep learning‐based smart assessment model for pressure injury surface. Design Exploratory analysis study. Methods Pressure images from four Guangzhou hospitals were labelled and used to train neural network model. Evaluation metrics included mean intersection over union (MIoU), pixel accuracy (PA), accuracy. Model performance was tested by comparing wound number, maximum dimensions area extent. Results From 1063 images, the achieved 74% IoU, 88% PA 83% bed...
Abstract Background Gamification uses game-based mechanics, aesthetics, and game thinking to engage people, motivate action, promote learning, solve problems. However, gaps remain in understanding implementing gamification rehabilitation care, necessitating further exploration clarification of the best evidence for application gamification. Objective To conduct a scoping review use care adults with chronic illnesses, summarizing scope, forms, elements, guiding theories, effectiveness, ease...
High-grade serous (HGS) ovarian cancer accounts for 90% of all cancer-related deaths. However, factors that drive HGS tumor growth have not been fully elucidated. In particular, comprehensive analysis the metabolic requirements has performed. By analyzing The Cancer Genome Atlas mRNA expression data patient samples, we observed six enzymes folic acid pathway were overexpressed in samples compared with normal ovary samples. Systematic knockdown genes using short hairpin RNAs (shRNAs) and...
DNA-binding protein inhibitor ID-1 (ID1) serves an essential role in tumor progression, and the self‑renewal pluripotency of embryonic stem cells. However, effect ID1 on stemness cancer cell (CSC)‑like properties gastric adenocarcinoma cells remains to be elucidated. In present study, effective knockdown was achieved (GC) using small interfering RNA, ability cisplatin (DDP) sensitivity GC subsequently examined. MKN‑28 MGC‑803 lines demonstrated significantly suppress colony formation...
As a continuation of our efforts directed towards the development natural anti-diabetic cataract agents, gigantol was isolated from Herba dendrobii and found to inhibit both aldose reductase (AR) inducible nitric oxide synthase (iNOS) activity, which play significant role in progression diabetic cataracts. To improve its bioefficacy facilitate use as therapeutic agent, (compound 14f) series novel analogs were designed synthesized. Analogs formulated have different substituents on phenyl ring...
Mutations in the NRAS oncogene are present up to 20% of melanoma. Here, we show that interferon alpha-inducible protein 6 (IFI6) is necessary for NRASQ61K-induced transformation and melanoma growth. IFI6 was transcriptionally upregulated by NRASQ61K, knockdown resulted DNA replication stress due dysregulated via E2F2. This consequentially inhibited cellular growth senescence or apoptosis induction depending on RB p53 pathway status cells. NRAS-mutant were significantly more resistant...