A5100386024- Cardiovascular Health and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Nutritional Studies and Diet
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Smoking Behavior and Cessation
- Health disparities and outcomes
- Global Cancer Incidence and Screening
- Birth, Development, and Health
- Cardiovascular Disease and Adiposity
- Arsenic contamination and mitigation
- Cancer Risks and Factors
- Diabetes Management and Research
- Frailty in Older Adults
- LGBTQ Health, Identity, and Policy
- Fluoride Effects and Removal
- Health, Environment, Cognitive Aging
- Chronic Disease Management Strategies
- Telomeres, Telomerase, and Senescence
- Complement system in diseases
- Acute Ischemic Stroke Management
- Religion, Spirituality, and Psychology
- Cancer survivorship and care
First Affiliated Hospital of Jinan University
2025
University of Oklahoma Health Sciences Center
2014-2024
Chengde Medical University
2022
Tianjin Centers for Disease Control and Prevention
2020-2022
Stomatology Hospital
2020
China Medical University
2020
Jilin University
2009
Second Affiliated Hospital of Jilin University
2009
University of Iowa
2008
Cornell University
2006
There are few data about the impact of recently-defined category prehypertension (systolic blood pressure 120 to 139 mm Hg or diastolic 80 89 Hg) on cardiovascular disease incidence. It is also unknown whether this association differs between individuals with without diabetes. A total 2629 Strong Heart Study participants free from hypertension and at baseline examination were followed for 12 years observe incident disease. Approximately 42% had We assessed prevalence hazard ratios associated...
Telomeres play a central role in cellular aging, and shorter telomere length has been associated with age-related disorders including diabetes. However, causal link between shortening diabetes risk not established. In well-characterized longitudinal cohort of American Indians participating the Strong Heart Family Study, we examined whether leukocyte (LTL) at baseline predicts incident independent known factors. Among 2,328 participants free baseline, 292 subjects developed during an average...
We used high-frequency stimulation delivered during the refractory period of atrium and pulmonary veins (PVs) to induce focal firing atrial fibrillation (AF). This study was designed demonstrate that bilateral low-level vagosympathetic nerve (LL-VNS) could suppress stimulation-induced AF at PV sites.In 23 dogs anesthetized with Na-pentobarbital, electrodes in trunks allowed LL-VNS 1 V below which slowed sinus rate or atrioventricular conduction. Multielectrode catheters were fixed right left...
Background Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in American Indian people. In 2022, the Heart Association developed Life's Essential 8 goals to promote cardiovascular health (CVH) for Americans, composed diet, physical activity, nicotine exposure, sleep, body mass index, blood lipids, pressure, glucose. We examined whether achievement was associated with incident CVD among SHFS (Strong Family Study) participants. Methods Results A total 2139 participants...
The present article presents equations for the prediction of coronary heart disease (CHD) in a population with high rates diabetes and albuminuria, derived from data collected Strong Heart Study, longitudinal study cardiovascular 13 American Indian tribes communities Arizona, North South Dakota, Oklahoma.Participants Study were examined initially 1989-1991 monitored additional examinations mortality morbidity surveillance. CHD outcome through December 2001 showed that age, gender, total...
Mannose-binding lectin (MBL) is a circulating immune factor responsible for opsonization of pathogens and directly activating complement. Common variations in the MBL gene are an opsonic deficiency that affects 5% to 7% whites associated with increased susceptibility infections. After preliminary report associating these coronary artery disease (CAD), we determined genotypes 3 American Indian communities experiencing mortality morbidity from CAD.We examined DNA 434 participants...
Although many studies on the association between dyslipidemia and cardiovascular disease (CVD) exist in older adults, data among adolescents young adults living with disproportionate burden of cardiometabolic disorders are scarce.
OBJECTIVE—To examine the associations between estrogen use and levels of insulin glucose as well effect on risk type 2 diabetes. RESEARCH DESIGN AND METHODS—This report is based 857 women who were both nondiabetic postmenopausal at baseline examination (1989–1992) completed a second (1993–1995) an average 4 years later. The participants divided into three groups: never, past, current users their status. ANCOVA was used to compare among groups. Logistic regression evaluate association...
Background: The mechanism(s) underlying atrial fibrillation (AF) initiation along the ligament of Marshall (LOM) remains controversial. Objectives: We sought to examine role autonomic nervous system in arrhythmogenesis LOM. Methods: In 31 anesthetized dogs, a left thoracotomy exposed During pacing, high‐frequency stimulation (HFS: 200 Hz, 0.1 ms pulse width, 40 duration, 0.6–12 V) was delivered during refractoriness different sites LOM (LOM CS = near coronary sinus; LIPV inferior pulmonary...
The objective of this study was to evaluate the association between measures body composition and patterns urine arsenic metabolites in 1989-1991 baseline visit Strong Heart Study, a cardiovascular disease cohort adults recruited from rural communities Arizona, Oklahoma, North Dakota South Dakota.We evaluated 3,663 Study participants with species above limit detection no missing data on mass index, % fat free measured by bioelectrical impedance, waist circumference other variables. We...
To examine changes in sexual functioning during treatment for lung cancer and the extent to which age, gender, social support, mood status affect dysfunction.Prospective, exploratory.Outpatient clinic.59 of 84 eligible patients diagnosed with small cell or non-small cancer.The Derogatis Interview Sexual Function, Self-Report, measure functioning; Social Provisions Scale support; Affects Balance were administered at diagnosis two four months treatment.Level function, treatment, status.Results...
APOB, APOC3, and APOE apolipoprotein-defined lipoprotein subclasses (ADLSs; based on qualitative apolipoprotein complement) have been associated with dyslipidemia CVD. Our main objective was to define associations of serum apolipoproteins ADLSs "any CVD" "major atherosclerotic cardiovascular events" (MACEs) in a prospective study T1D. Serum (14 biomarkers total) were measured sera (obtained between 1997 2000) from subset (n = 465) the Epidemiology Diabetes Interventions Complications cohort....
Abstract Context: Elevated LDL cholesterol (LDL-C) is an important risk factor for atherosclerosis and cardiovascular disease. Variants in the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene have been associated not only with plasma LDL-C concentration, but also ischemic heart Little known about genetic architecture of PCSK9 its influence on American Indians. Objective: We aimed to investigate 1p32 region encompassing Design: The Strong Heart Family Study (SHFS) a family-based...
Despite the high burden of diabetes and cardiovascular risk factors in American Indian communities United States, prospective studies heart failure (HF) this population group are scarce, generalizability previous HF scales may be limited. We developed a parsimonious prediction equation that accounts for relevant affecting communities, focusing on kidney damage.
The metabolic abnormalities that accompany diabetes mellitus are associated with an increased risk of many cancers. These associations, however, have not been well studied in American Indian populations, which experience a high prevalence diabetes. Strong Heart Study is population-based, prospective cohort study extensive characterization status. Among total 4,419 participants who were followed for up to 20 years, 430 cancer deaths identified. After adjusting sex, age, education, smoking...
Background American Indians ( AIs ) have high stroke morbidity and mortality. We compared incidence mortality in AI s, blacks, whites. Methods Results Pooled data from 2 cardiovascular disease cohort studies included 3182 s the SHS (Strong Heart Study), aged 45 to 74 years at baseline (1988-1990) 3765 blacks 10 413 whites ARIC (Atherosclerosis Risk Communities) Study, 64 (1987-1989). Stroke surveillance was based on self-report, hospital records, death certificates. estimated hazard ratios...
Prevalence of insulin resistance is high in the American Indian population, likely as a result prevalence obesity. This condition may be influential for clinical outcomes such cardiovascular disease (CVD) and decreased kidney function.Normal glucose tolerant (NGT) participants free hypertension CVD at baseline examination (1989-1992) (N=964) Strong Heart Study were selected to explore cross-sectional association between quantified by homeostasis model assessment (HOMA-IR) demographic,...
There is currently limited information on the prognostic value of dNLR-PNI (the combination derived neutrophil-to-lymphocyte ratio [dNLR] and nutritional index [PNI]) score for patients with acute coronary syndrome (ACS). We aimed to explore predictive a long-term prognosis ACS undergoing percutaneous intervention (PCI). A total 1773 who underwent PCI were consecutively enrolled from January 2016 December 2018. The cutoff values dNLR PNI predict major adverse cardiovascular events (MACE)...