A5089230593- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 epidemiological studies
- Animal Virus Infections Studies
- Clostridium difficile and Clostridium perfringens research
- Infection Control and Ventilation
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Vaccine Coverage and Hesitancy
- Salmonella and Campylobacter epidemiology
- Pediatric health and respiratory diseases
- Pneumonia and Respiratory Infections
- Virus-based gene therapy research
- Obesity, Physical Activity, Diet
- COVID-19 Digital Contact Tracing
- Breastfeeding Practices and Influences
- Data-Driven Disease Surveillance
- Heavy Metal Exposure and Toxicity
- Cerebral Palsy and Movement Disorders
- Nutritional Studies and Diet
- Gestational Diabetes Research and Management
- Tracheal and airway disorders
- Maternal Mental Health During Pregnancy and Postpartum
Centers for Disease Control and Prevention
2018-2025
National Center for Immunization and Respiratory Diseases
2019-2024
Cherokee Nation
2020-2024
Kaiser Permanente Center for Health Research
2022-2024
Oak Ridge Associated Universities
2018-2023
Oak Ridge Institute for Science and Education
2018-2023
Government of the United States of America
2023
Emory University
2021
Response Biomedical (Canada)
2020
Atlas Copco (United States)
2020
US Department of Health and Human Services/Centers for Disease Control Prevention to mask wearing, physical distancing, hand hygiene).To ensure accurate surveillance, it is important that health care providers departments assure follow-up infants, children, adolescents, young adults infected with or exposed SARS-CoV-2 document report underlying medical conditions cause death related COVID-19.Health departments, in collaboration school districts the communities they serve, can evaluate...
An illness was categorized as one compatible with COVID-19 if symptoms met the Council of State and Territorial Epidemiologists (CSTE) clinical criteria in case definition, including 1) cough, shortness breath, or difficulty breathing 2) two more other (fever [measured subjective], chills, rigors, myalgia, headache, sore throat, new olfactory taste disorders).https://cdn.ymaws.com/www.cste.org/resource/resmgr/2020ps/interim-20id-01_covid-19.pdf.reported here does not represent seroprevalence...
Abstract Background Up-to-date estimates of the burden norovirus, a leading cause acute gastroenteritis (AGE) in United States, are needed to assess potential value norovirus vaccines development. We aimed estimate rates, annual counts, and healthcare charges norovirus-associated ambulatory clinic encounters, emergency department (ED) visits, hospitalizations, deaths States. Methods analyzed administrative data on AGE outcomes from 1 July 2001 through 30 June 2015. Data were sourced IBM...
Acute gastroenteritis (AGE) causes a substantial burden in the United States, but its etiology frequently remains undetermined. Active surveillance within an integrated healthcare delivery system was used to estimate prevalence and incidence of medically attended norovirus, rotavirus, sapovirus, astrovirus.Active conducted among all enrolled members Kaiser Permanente Northwest during July 2014-June 2016. An age-stratified, representative sample AGE-associated medical encounters were...
Abstract Background Acute bronchiolitis due to respiratory syncytial virus (RSV) is the leading cause of hospitalizations in infants United States. Most available data on RSV epidemiology were obtained from hospital cohorts or medically attended illnesses, focusing symptomatic children. We examined PREVAIL Cohort (2017–2020) healthy, term Cincinnati, Ohio understand infections a birth cohort under weekly surveillance. Table 1 Medical attendance by age group, Cohort, Ohio, 2017–2020 Methods...
Abstract Background In the United States, norovirus is leading cause of healthcare-associated gastroenteritis outbreaks. To inform prevention efforts, we describe epidemiology outbreaks in long-term care facilities (LTCFs). Methods The Centers for Disease Control and Prevention (CDC) collect epidemiologic laboratory data on from US health departments through National Outbreak Reporting System (NORS) CaliciNet. Reports both systems were merged, nursing homes, assisted living, other LTCFs...
Abstract Knowledge of the epidemiology sporadic acute gastroenteritis (AGE) in United States is limited. During September 2016–September 2017, we surveyed Kaiser Permanente Northwest members Oregon and Washington, USA, to collect data on 30-day prevalence dually defined AGE diarrhea disease related health-seeking behavior; from a subset participants, obtained stool specimen. Using iterative proportional fitting algorithm with raked weights, generated annualized rate estimates. We detected...
Coronavirus disease 2019 (COVID-19), the respiratory caused by severe acute syndrome coronavirus 2 (SARS-CoV-2), was first identified in Wuhan, China and has since become pandemic. In response to cases United States, close contacts of confirmed COVID-19 were investigated enable early identification isolation additional learn more about risk factors for transmission. Close nine travel-related States monitored daily development symptoms (active monitoring). Selected (including those with...
Abstract Background The National Outbreak Reporting System (NORS) captures data on foodborne, waterborne, and enteric illness outbreaks in the United States. This study describes reported during 11 years of surveillance. Methods We extracted finalized reports from NORS for occurring 2009–2019. Outbreaks were included if caused by an etiology or any patients diarrhea, vomiting, bloody stools, unspecified acute gastroenteritis. Results A total 38 395 met inclusion criteria, increasing 1932...
Abstract Background Respiratory viral infections are a major cause of morbidity and hospitalization in young children. Nevertheless, the population burden respiratory infections, especially asymptomatic cases, is not known due to lack prospective community-based cohort studies with intensive monitoring. Methods To address this gap, we enacted PREVAIL cohort, Centers for Disease Control Prevention–sponsored birth Cincinnati, Ohio, where children were followed from 0 2 years age. Weekly text...
Abstract Background Respiratory viral shedding is incompletely characterized by existing studies due to the lack of longitudinal nasal sampling and limited inclusion healthy/asymptomatic children. We describe characteristics associated with prolonged virus detection polymerase chain reaction (PCR) in a community-based birth cohort. Methods Children were followed from 2 years age PREVAIL Weekly swabs collected tested using Luminex Pathogen Panel. text surveys administered ascertain presence...
Abstract During 2009–2018, four adenovirus, 10 astrovirus, 123 rotavirus, and 107 sapovirus gastroenteritis outbreaks were reported to the US National Outbreak Reporting System (annual median 30 outbreaks). Most attributable person-to-person transmission in long-term care facilities, daycares, schools. Investigations of norovirus-negative should include testing for these viruses.
Globally, noroviruses cause infections year-round but have recognized winter seasonality in the Northern Hemisphere and yearly variations incidence. With candidate norovirus vaccines development, understanding temporal geographic trends disease is important to inform potential vaccination strategies evaluate vaccine impact.
OBJECTIVES Acute gastroenteritis (AGE) outbreaks commonly occur in congregate settings, including schools and childcare facilities. These disrupt institutions, causing absences temporary facility closures. This study analyzed the epidemiology of school AGE United States. METHODS We occurring kindergarten to grade 12 facilities reported via National Outbreak Reporting System States from 2009 2019 compared this information 2020 data. case characteristics were using Kruskal-Wallis rank sum...
Abstract Background Rotavirus is a leading cause of severe pediatric gastroenteritis; 2 highly effective vaccines are used in the United States (US). We aimed to identify correlates immune response rotavirus vaccination US cohort. Methods Pediatric Respiratory and Enteric Virus Acquisition Immunogenesis Longitudinal (PREVAIL) birth cohort 245 mother-child pairs enrolled 2017–2018 followed for years. Infant stool samples symptom information were collected weekly. Shedding was defined as...
With recent advances in U.S. clinical trials for norovirus vaccines, it is an opportune time to examine what known about the public receptivity this novel vaccine. From October 2016–September 2017, we surveyed Kaiser Permanente Northwest members Portland, Oregon, ask their level of agreement on a 5-point scale with statements need and willingness get potential vaccine themselves or child analyzed responses according age, occupational status, prior uptake, history diagnoses. The survey...
The endemic coronaviruses OC43, HKU1, NL63, and 229E cause cold-like symptoms are related to SARS-CoV-2, but their natural histories poorly understood. In a cohort of children followed from birth 4 years, we documented all coronavirus infections, including understand protection against subsequent infections with the same virus (homotypic immunity) or different (heterotypic immunity).
Norovirus-associated acute gastroenteritis (AGE) exacts a substantial disease burden, yet the health care utilization for and clinical management of norovirus-associated AGE are not well characterized. We describe encounters therapeutics used patients with all-cause in Kaiser Permanente Northwest system from 1 April 2014 through 30 September 2016. Medical were extracted electronic records, within days one another grouped into single episodes. An age-stratified random sample completed surveys...
We conducted a large surveillance study among members of an integrated healthcare delivery system in Pacific Northwest the United States to estimate medical costs attributable medically attended acute gastroenteritis (MAAGE) on day care was sought and during 30-day follow-up. used multivariable regression compare MAAGE non-MAAGE cases matched age, gender, index time. Differences accounted for confounders, including race, ethnicity, history chronic underlying conditions. Analyses included...
ABSTRACT Background Coronavirus disease 2019 (COVID-19), the respiratory caused by severe acute syndrome coronavirus 2 (SARS-CoV-2), was first identified in Wuhan, China and has since become pandemic. As part of initial response activities United States, enhanced contact investigations were conducted to enable early identification isolation additional cases learn more about risk factors for transmission. Methods Close contacts nine travel-related States identified. meeting criteria active...
Norovirus outbreaks are notoriously explosive, with dramatic symptomology and rapid disease spread. Children particularly vulnerable to infection drive norovirus transmission due their high contact rates each other the environment. Despite explosive nature of outbreaks, attack in schools daycares remain low majority students not reporting symptoms.
Summary Background Neighbourhood socio‐economic environment (SEE) is associated with obesity in older children and adults, but little known about this relationship younger children. Breastfeeding an important preventative of adiposity childhood, its neighbourhood SEE unknown. Aims We assessed differences before age two by SEE, controlling for family socio‐demographics breastfeeding duration. Materials Methods Family socio‐demographics, child body mass index z scores (BMI ), duration were...
Noroviruses are the leading cause of acute gastroenteritis in United States and outbreaks frequently occur daycare settings. Results norovirus vaccine trials have been promising, however there open questions as to whether vaccination children would be cost-effective. We investigated incremental cost-effectiveness a hypothetical for settings compared no vaccination. conducted model-based analysis using disease transmission model attending daycare. Vaccination with 90% coverage rate addition...