Mary Allen Staat
A5055459640- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Kawasaki Disease and Coronary Complications
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 Impact on Reproduction
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Child and Adolescent Health
- Child Welfare and Adoption
- Clostridium difficile and Clostridium perfringens research
- Long-Term Effects of COVID-19
- Congenital Anomalies and Fetal Surgery
- Streptococcal Infections and Treatments
- Pediatric health and respiratory diseases
- Migration, Health and Trauma
- Breastfeeding Practices and Influences
- Tracheal and airway disorders
- Tuberculosis Research and Epidemiology
Cincinnati Children's Hospital Medical Center
2016-2025
University of Cincinnati Medical Center
2013-2025
University of Cincinnati
2013-2025
Children's Hospital & Medical Center
2012-2024
University of Chicago
2009-2024
Texas Children's Hospital
2020-2024
Children's Hospital of Pittsburgh
2022-2024
Vanderbilt University
2006-2024
Jewish Hospital
2024
Hennepin County
2024
The primary role of respiratory syncytial virus (RSV) in causing infant hospitalizations is well recognized, but the total burden RSV infection among young children remains poorly defined.We conducted prospective, population-based surveillance acute infections under 5 years age three U.S. counties. We enrolled hospitalized from 2000 through 2004 and presenting as outpatients emergency departments pediatric offices 2002 2004. was detected by culture reverse-transcriptase polymerase chain...
The disease burden of influenza infection among children is not well established. We conducted a population-based surveillance medical visits associated with laboratory-confirmed influenza.
Cases of rotavirus-associated acute gastroenteritis have declined since the introduction rotavirus vaccines, but burden norovirus-associated in children remains to be assessed.We conducted active surveillance for laboratory-confirmed cases norovirus among younger than 5 years age with hospitals, emergency departments, and outpatient clinical settings. The resided one three U.S. counties during 2009 2010. Fecal specimens were tested rotavirus. We calculated population-based rates reviewed...
Respiratory syncytial virus (RSV) infection is a leading cause of hospitalization among infants. However, estimates the RSV burden have varied, and precision has been limited by use age strata grouped in blocks 6 to ≥ 12 months.We analyzed data from 5-year, prospective, population-based surveillance for young children who were hospitalized with laboratory-confirmed (reverse-transcriptase polymerase chain reaction) acute respiratory illness (ARI) during October through March 2000-2005. The...
Coronavirus disease 2019 (COVID-19) affects the nervous system in adult patients. The spectrum of neurologic involvement children and adolescents is unclear.To understand range severity among associated with COVID-19.Case series patients (age <21 years) hospitalized between March 15, 2020, December positive severe acute respiratory syndrome coronavirus 2 test result (reverse transcriptase-polymerase chain reaction and/or antibody) at 61 US hospitals Overcoming COVID-19 public health...
The inpatient and outpatient burden of human metapneumovirus (HMPV) infection among young children has not been well established.We conducted prospective, population-based surveillance for acute respiratory illness or fever less than 5 years age in three U.S. counties from 2003 through 2009. Clinical demographic data were obtained parents medical records, HMPV was detected by means a reverse-transcriptase polymerase-chain-reaction assay, rates hospitalization estimated visits associated with...
Multisystem inflammatory syndrome in children (MIS-C) is a severe postinfectious hyperinflammatory condition, which generally occurs 2-6 weeks after typically mild or asymptomatic infection with SARS-CoV-2, the virus that causes COVID-19 (1-3). In United States, BNT162b2 (Pfizer-BioNTech) vaccine currently authorized for use and adolescents aged 5-15 years under an Emergency Use Authorization fully licensed by Food Drug Administration persons ≥16 (4). Prelicensure randomized trials ≥5...
Background. The contribution of human rhinovirus (HRV) to severe acute respiratory illness (ARI) is unclear. Objective. To assess the association between HRV species detection and ARI hospitalizations. Methods. Children <5 years old hospitalized for were prospectively enrolled December 2003 April 2005 in 3 US counties. Asymptomatic controls March 2004 October clinics. Nasal throat swab samples tested other viruses (ie, syncytial virus, metapneumovirus, parainfluenza influenza virus) by...
Spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 (omicron) variant, which led to increased U.S. hospitalizations for disease 2019 (Covid-19), generated concern about immune evasion and duration protection from vaccines in children adolescents.Using a case-control, test-negative design, we assessed vaccine effectiveness against laboratory-confirmed Covid-19 leading hospitalization critical (i.e., receipt life support or death). From July 1, 2021, February...
Although rotavirus and norovirus cause nearly 40% of severe endemic acute gastroenteritis (AGE) in children <5 years age the United States, there are limited data on etiologic role other enteric viruses this group.We conducted active population-based surveillance presenting with AGE to hospitals, emergency departments, primary care clinics 3 US counties. Stool specimens from these age-matched healthy controls collected between October 2008 September 2009 were tested for adenovirus,...
Respiratory syncytial virus (RSV) is a major cause of hospitalized acute respiratory illness (ARI) among young children. With RSV vaccines and immunoprophylaxis agents in clinical development, we sought to update estimates US pediatric hospitalization burden.Children <5 years old for ARI were enrolled through active, prospective, population-based surveillance from November 1, 2015, June 30, 2016, at 7 hospital sites. Clinical information was obtained parent interviews medical records....
Infants younger than 6 months of age are at high risk for complications coronavirus disease 2019 (Covid-19) and not eligible vaccination. Transplacental transfer antibodies against severe acute respiratory syndrome 2 (SARS-CoV-2) after maternal Covid-19 vaccination may confer protection in infants.
COVID-19 vaccination is recommended for persons who are pregnant, breastfeeding, trying to get pregnant now, or might become in the future, protect them from COVID-19.§ Infants at risk life-threatening complications COVID-19, including acute respiratory failure (1). Evidence other vaccine-preventable diseases suggests that maternal immunization can provide protection infants, especially during high-risk first 6 months of life, through passive transplacental antibody transfer (2). Recent...
Most children will experience some type of trauma during childhood, and many suffer from significant adversities. Research in genetics, neuroscience, epidemiology all provide evidence that these experiences have effects at the molecular, cellular, organ level, with consequences on physical, emotional, developmental, behavioral health across life span. Trauma-informed care translates science to inform improve pediatric outcomes. To practically address promote resilience, clinicians need tools...
<h3>Importance</h3> Childhood community-acquired pneumonia (CAP) is usually treated with 10 days of antibiotics. Shorter courses may be effective fewer adverse effects and decreased potential for antibiotic resistance. <h3>Objective</h3> To compare a short (5-day) vs standard (10-day) treatment strategy CAP in young children. <h3>Design, Setting, Participants</h3> Randomized double-blind placebo-controlled clinical trial outpatient clinic, urgent care, or emergency settings 8 US cities. A...
The increasing incidence of pediatric hospitalizations associated with coronavirus disease 2019 (Covid-19) caused by the B.1.617.2 (delta) variant severe acute respiratory syndrome 2 (SARS-CoV-2) in United States has offered an opportunity to assess real-world effectiveness BNT162b2 messenger RNA vaccine adolescents between 12 and 18 years age.
The New Vaccine Surveillance Network (NVSN) is a prospective, active, population-based surveillance platform that enrolls children with acute respiratory illnesses (ARIs) at seven pediatric medical centers. ARIs are caused by viruses including influenza virus, syncytial virus (RSV), human metapneumovirus (HMPV), parainfluenza (HPIVs), and most recently SARS-CoV-2 (the causes COVID-19), which result in morbidity among infants young (1-6). NVSN estimates the incidence of pathogen-specific...
Respiratory syncytial virus (RSV) is the leading cause of hospitalization among infants in United States. In August 2023, CDC's Advisory Committee on Immunization Practices recommended nirsevimab, a long-acting monoclonal antibody, for aged <8 months to protect against RSV-associated lower respiratory tract infection during their first RSV season and children 8-19 at increased risk severe disease. phase 3 clinical trials, nirsevimab efficacy with was 81% (95% CI = 62%-90%) through 150 days...
Rhinoviruses and/or enteroviruses, which continued to circulate during the COVID-19 pandemic, are commonly detected in pediatric patients with acute respiratory illness (ARI). Yet detailed characterization of rhinovirus enterovirus detection over time is limited, especially by age group and health care setting.
In the United States, annual influenza vaccination is recommended for all persons aged ≥6 months.Using data from four vaccine effectiveness (VE) networks during 2023-24 season, interim VE was estimated among patients months with acute respiratory illness-associated medical encounters using a test-negative casecontrol study design.Among children and adolescents 6 months-17 years, against influenza-associated outpatient visits ranged 59% to 67% hospitalization 52% 61%.Among adults ≥18 33% 49%...
BACKGROUND Respiratory syncytial virus (RSV) is the leading cause of hospitalization in US infants. Accurate estimates severe RSV disease inform policy decisions for prevention. METHODS We conducted prospective surveillance children &lt;5 years old with acute respiratory illness from 2016 to 2020 at 7 pediatric hospitals. interviewed parents, reviewed medical records, and tested midturbinate nasal ± throat swabs by reverse transcription polymerase chain reaction other viruses. describe...