Stacey L. House
A5029306364- Posttraumatic Stress Disorder Research
- Traumatic Brain Injury Research
- Resilience and Mental Health
- Respiratory viral infections research
- Migration, Health and Trauma
- Child Abuse and Trauma
- Fibroblast Growth Factor Research
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Stress Responses and Cortisol
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Nitric Oxide and Endothelin Effects
- SARS-CoV-2 and COVID-19 Research
- Asthma and respiratory diseases
- Psychosomatic Disorders and Their Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac electrophysiology and arrhythmias
- Anesthesia and Neurotoxicity Research
- Functional Brain Connectivity Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 detection and testing
- Pulmonary Hypertension Research and Treatments
- Antimicrobial Resistance in Staphylococcus
- Cognitive Abilities and Testing
Washington University in St. Louis
2015-2025
Hennepin County
2024
Cincinnati Children's Hospital Medical Center
2024
Vanderbilt University
2024
Texas Children's Hospital
2024
Children's Mercy Hospital
2024
Seattle Children's Hospital
2024
Jewish Hospital
2024
Barnes-Jewish Hospital
2024
University of Arizona
2024
We pursued a study of immune responses in coronavirus disease 2019 (COVID-19) and influenza patients. Compared to patients with influenza, COVID-19 exhibited largely equivalent lymphocyte counts, fewer monocytes, lower surface human leukocyte antigen (HLA)-class II expression on selected monocyte populations. Furthermore, decreased HLA-DR intermediate monocytes predicted severe disease. In contrast prevailing assumptions, very few (7 168) cytokine profiles indicative storm syndrome. After...
In the United States, annual influenza vaccination is recommended for all persons aged ≥6 months.Using data from four vaccine effectiveness (VE) networks during 2023-24 season, interim VE was estimated among patients months with acute respiratory illness-associated medical encounters using a test-negative casecontrol study design.Among children and adolescents 6 months-17 years, against influenza-associated outpatient visits ranged 59% to 67% hospitalization 52% 61%.Among adults ≥18 33% 49%...
The 2023-24 U.S. influenza season was characterized by a predominance of A(H1N1)pdm09 virus circulation with co-circulation A(H3N2) and B/Victoria viruses. We estimated vaccine effectiveness (VE) in the United States against mild-to-moderate medically attended illness season. enrolled outpatients aged ≥8 months acute respiratory 7 states. Respiratory specimens were tested for type/subtype reverse-transcriptase polymerase chain reaction (RT-PCR). Influenza VE test-negative design comparing...
Major negative life events, such as trauma exposure, can play a key role in igniting or exacerbating psychopathology. However, few disorders are diagnosed with respect to precipitating and the of these events unfolding new psychopathology is not well understood. The authors conducted multisite transdiagnostic longitudinal study exposure related mental health outcomes identify neurobiological predictors risk, resilience, different symptom presentations.
Objective: Dissociation, a disruption or discontinuity in psychological functioning, is often linked with worse psychiatric symptoms; however, the prognostic value of dissociation after trauma inconsistent. Determining whether trauma-related uniquely predictive later outcomes would enable early identification at-risk populations. The authors conducted largest prospective longitudinal biomarker study persistent to date determine its capacity for adverse following acute trauma. Methods: All...
Considerable racial/ethnic disparities persist in exposure to life stressors and socioeconomic resources that can directly affect threat neurocircuitry, particularly the amygdala, partially mediates susceptibility adverse posttraumatic outcomes. Limited work date, however, has investigated potential variability amygdala reactivity or connectivity may turn be related outcomes such as post-traumatic stress disorder (PTSD). Participants from AURORA study (n = 283), a multisite longitudinal of...
Abstract Patients exposed to trauma often experience high rates of adverse post-traumatic neuropsychiatric sequelae (APNS). The biological mechanisms promoting APNS are currently unknown, but the microbiota-gut-brain axis offers an avenue understanding as well possibilities for intervention. Microbiome composition after exposure has been poorly examined regarding outcomes. We aimed determine whether gut microbiomes trauma-exposed emergency department patients who develop have dysfunctional...
Preconditioning the heart before an ischemic insult has been shown to protect against contractile dysfunction, arrhythmias, and infarction. Pharmacological studies have suggested that fibroblast growth factor-2 (FGF2) is involved in cardioprotection. However, because of number FGFs expressed promiscuity FGF ligand-receptor interactions, specific role FGF2 during ischemia-reperfusion injury remains unclear.FGF2-deficient (Fgf2 knockout) mice with a cardiac-specific overexpression all 4...
Fibroblast growth factor (FGF) signaling is cardioprotective in various models of myocardial infarction. FGF receptors (FGFRs) are expressed multiple cell types the adult heart, but type-specific FGFR that mediates different endpoints not known. To determine requirement for endothelium cardiac ischemia-reperfusion injury, we conditionally inactivated Fgfr1 and Fgfr2 genes endothelial cells with Tie2-Cre (Tie2-Cre, Fgfr1(f/f), Fgfr2(f/f) DCKO mice). Tie2-Cre, mice had normal baseline...
Abstract Visual components of trauma memories are often vividly re-experienced by survivors with deleterious consequences for normal function. Neuroimaging research on has primarily focused threat-processing circuitry as core to trauma-related dysfunction. Conversely, limited attention been given visual which may be particularly relevant posttraumatic stress disorder (PTSD). Prior work suggests that the ventral stream is directly related cognitive and affective disturbances observed in PTSD...
Influenza and respiratory syncytial virus (RSV) are associated with substantial morbidity mortality in the United States. We assessed risk factors for severe disease medical resource utilization (MRU) among US adults hospitalized influenza or RSV Hospitalized Acute Respiratory Tract Infection (HARTI) study. HARTI was a prospective global (40 centers, 12 countries) epidemiological study of acute tract infections conducted across 2017-2019 epidemic seasons. Patients confirmed were followed up...
Importance Adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure are common and have higher incidence among socioeconomically disadvantaged populations. Pain, depression, avoidance of trauma reminders, reexperiencing trauma, anxiety, hyperarousal, sleep disruption, nightmares been reported. Wrist-wearable devices with accelerometers capable assessing 24-hour rest-activity characteristics prevalent may utility in measuring these outcomes. Objective To evaluate...
Fibroblast growth factor 2 (basic FGF or FGF2) has been shown to affect and differentiation in some tissues be required for cardiac hypertrophy vivo. FGF2 vitro signal through the mitogen-activated protein kinase (MAPK) cell survival growth. To ascertain role of hypertrophy, wildtype, Fgf2 knockout, non-transgenic, transgenic mice were treated with isoproterenol saline via subcutaneous mini-osmotic pump implants induce a hypertrophic response β-adrenergic stimulation. knockout hearts are...