Benjamin R Clopper
A5004954406- Respiratory viral infections research
- Influenza Virus Research Studies
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Pediatric health and respiratory diseases
- Tracheal and airway disorders
- Emergency and Acute Care Studies
- Viral Infections and Outbreaks Research
- Water Treatment and Disinfection
- Legionella and Acanthamoeba research
- Immunodeficiency and Autoimmune Disorders
- Viral Infections and Vectors
- Neonatal Respiratory Health Research
- Vibrio bacteria research studies
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Respiratory Support and Mechanisms
Centers for Disease Control and Prevention
2021-2025
National Center for Immunization and Respiratory Diseases
2024
Children's Hospital of Pittsburgh
2022-2024
Barnes-Jewish Hospital
2024
University of Arizona
2024
Seattle Children's Hospital
2024
University of Colorado Hospital
2024
University of Michigan
2024
Oregon Health and Science University Hospital
2024
University of Colorado Denver
2024
The New Vaccine Surveillance Network (NVSN) is a prospective, active, population-based surveillance platform that enrolls children with acute respiratory illnesses (ARIs) at seven pediatric medical centers. ARIs are caused by viruses including influenza virus, syncytial virus (RSV), human metapneumovirus (HMPV), parainfluenza (HPIVs), and most recently SARS-CoV-2 (the causes COVID-19), which result in morbidity among infants young (1-6). NVSN estimates the incidence of pathogen-specific...
Respiratory syncytial virus (RSV) is the leading cause of hospitalization among infants in United States. In August 2023, CDC's Advisory Committee on Immunization Practices recommended nirsevimab, a long-acting monoclonal antibody, for aged <8 months to protect against RSV-associated lower respiratory tract infection during their first RSV season and children 8-19 at increased risk severe disease. phase 3 clinical trials, nirsevimab efficacy with was 81% (95% CI = 62%-90%) through 150 days...
In the United States, annual influenza vaccination is recommended for all persons aged ≥6 months.Using data from four vaccine effectiveness (VE) networks during 2023-24 season, interim VE was estimated among patients months with acute respiratory illness-associated medical encounters using a test-negative casecontrol study design.Among children and adolescents 6 months-17 years, against influenza-associated outpatient visits ranged 59% to 67% hospitalization 52% 61%.Among adults ≥18 33% 49%...
The coronavirus disease 2019 pandemic disrupted respiratory syncytial virus (RSV) seasonality resulting in early, atypical RSV seasons 2021 and 2022, with an intense 2022 peak overwhelming many pediatric healthcare facilities.
Abstract Background During the COVID-19 pandemic, seasonal respiratory virus detections decreased. However, rhinoviruses (RV) continued to circulate in high numbers. Previous data suggest that RV type circulation is heterogenous and diverse. We characterized distribution of species diversity types among children with medically attended acute infection (ARI) during first year pandemic. *Spring: Feb Apr, Summer: May July, Fall: Aug Oct, Winter: Nov Jan.Table 1.Age, ED/hospitalization status...
Abstract Background SARS-CoV-2 has evolved since its emergence in late December 2019, with evidence for increased contagiousness, evasion of immunity and missed detection by diagnostic assays. genomic surveillance children is important to evaluate impact the variants on pediatric COVID-19 disease. Methods During April 2021-October 2023, New Vaccine Surveillance Network conducted active, prospective acute respiratory illness (ARI) among (&lt; 18 years). Children ARI symptoms were enrolled...
Abstract Background Human adenovirus (HAdV) is a common cause of acute respiratory illness (ARI) in children, ranging from asymptomatic to life-threatening disease. While previous studies have examined vs HAdV ARI infections, few analyzed species and type. We compared frequencies types among children with vs. healthy controls (HCs). Comparison demographics detection between controls: New Vaccine Surveillance Network 12/01/2016–11/30/2019 (N=1,393). Methods Data were the Network, multicenter,...
Abstract Background Current diagnostic methods for RSV and other respiratory viruses primarily rely on reverse transcription polymerase chain reaction (RT-PCR) testing of nasopharyngeal (NPS) or nasal mid-turbinate (MTS) swabs. Recent data in adults suggest saliva increases yield RSV. However, the potential as a specimen type detecting children remains understudied. We compared paired MTS samples detection children. Methods Between February 1 to April 15, 2024, total 206 obtained using...
Annual influenza vaccination is recommended for all persons aged ≥6 months in the United States. Interim vaccine effectiveness (VE) was calculated among patients with acute respiratory illness-associated outpatient visits and hospitalizations from four VE networks during 2024-25 season (October 2024-February 2025). Among children adolescents <18 years, against any 32%, 59%, 60% setting three networks, influenza-associated hospitalization 63% 78% two networks. adults ≥18 36% 54% 41% 55%...
SARS-CoV-2 infection in young children is often mild or asymptomatic; however, some are at risk for severe disease. Data describing the protective effectiveness of COVID-19 mRNA vaccines against COVID-19-associated emergency department (ED) visits and hospitalization this population limited. from New Vaccine Surveillance Network, a prospective population-based surveillance system, were used to estimate vaccine using test-negative, case-control design describe epidemiology infants aged 6...
We piloted a methodology for collecting and interpreting root cause—or environmental deficiency (ED)—information from Legionnaires’ disease (LD) outbreak investigation reports. The included classification framework to assess common failures observed in the implementation of water management programs (WMPs). reviewed reports fourteen CDC-led investigations between 1 January 2015 21 June 2019 identify EDs associated with outbreaks LD. developed an abstraction guide standardize data collection...
Importance During the 2023-2024 respiratory syncytial virus (RSV) season in United States, 2 new RSV prevention products were recommended to protect infants their first season: nirsevimab and Pfizer’s maternal vaccine. Postlicensure studies are needed assess product impact effectiveness. Objective To compare epidemiology disease burden of medically attended RSV-associated acute illness (ARI) among children younger than 5 years during with 3 prepandemic seasons (2017-2020), estimate...
Abstract Background Previous investigations into clinical signs and symptoms associated with influenza types subtypes have not definitively established differences in the presentation or severity of disease. Methods The study population included children 0–17 years old enrolled at 8 New Vaccine Surveillance Network sites between 2015 2020 who tested positive for virus by molecular testing. Demographic data were collected participants via parent/guardian interviews medical chart reviews....
Abstract Background Guidelines state that all hospitalized children with suspected or confirmed influenza receive prompt treatment influenza-specific antivirals. We sought to determine the frequency of, and factors associated with, antiviral receipt among children. Methods conducted active surveillance of presenting fever respiratory symptoms from 1 December 2016 31 March 2020 at 7 pediatric medical centers in New Vaccine Surveillance Network. The cohort consisted A B by clinical research...
Importance Increasing the understanding of vaccine effectiveness (VE) against levels severe influenza in children could help increase uptake vaccination and strengthen policies globally. Objective To investigate VE by severity illness. Design, Setting, Participants This case-control study with a test-negative design used data from 8 participating medical centers located geographically different US states New Vaccine Surveillance Network November 6, 2015, through April 8, 2020. included 6...
Abstract Background Respiratory pathogen panels (RPP) are multiplex PCR platforms that detect several respiratory viruses from one specimen. For most children hospitalized with acute illness (ARI), management is supportive, and detection of a specific virus RPP does not impact clinical care. Therefore, use standardized, ordering at the discretion clinician. We sought to understand factors associated utilization among pediatric patients ARI. Methods From October 2017 September 2021,...
Abstract Background Children hospitalized with suspected or confirmed influenza should promptly receive antivirals, as recommended by the Infectious Diseases Society of America, American Academy Pediatrics, and Centers for Disease Control Prevention (CDC). However, despite these recommendations, antiviral receipt remains suboptimal. We assessed predictors in children. Methods conducted active, population-based surveillance children presenting fever respiratory symptoms from December 1, 2016,...
Abstract Background Respiratory viruses are a substantial cause of hospitalization in infants and young children; less is known about their contribution to ARI-associated hospitalizations children ≥ 5 years age. Methods We conducted prospective, active surveillance among ages 5–17 hospitalized for acute respiratory illness (ARI) at 7 pediatric medical institutions comprising the New Vaccine Surveillance Network (NVSN) during December 1, 2016 through April 2020. Children fever and/or symptoms...
Abstract Background Children with underlying medical conditions are at higher risk for developing severe influenza illness. Annual vaccination is recommended all children ≥ 6 months and can protect against influenza. Limited studies have examined if vaccine effectiveness (VE) illness differs in compared to those without. Methods We used a test-negative design assess VE laboratory-confirmed influenza-associated ED visits or hospitalizations months-17 years of age without conditions. were...
Abstract Background Provisional US data indicated that enterovirus D68 (EV-D68) circulated during summer 2022. However, in contrast to 2018 (a previous high circulation year), EV-D68 2022 was associated with unusual increases asthma-specific healthcare visits and a lack of concomitant acute flaccid myelitis (AFM). To explore these distinctions by year, we characterized respiratory compared patient characteristics 2018. Methods We enrolled children aged &lt; 18 years illness (ARI) seeking...
Abstract Background Adenovirus (AdV) is a common cause of acute respiratory illness (ARI). Multiple AdV types have been identified in humans, but it remains unclear which are the most U.S. children with ARI. Methods We conducted multicenter, prospective viral surveillance study at seven children’s hospitals, New Vaccine Surveillance Network, during 12/1/16–11/30/19, prior to COVID-19 pandemic. Children &lt; 18 years age seen emergency department or hospitalized fever and/or symptoms were...